Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michelle R. Simpson-Abelson"'
Autor:
Michelle R Simpson-Abelson, Erin E Childs, M Carolina Ferreira, Shrinivas Bishu, Heather R Conti, Sarah L Gaffen
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136538 (2015)
Humans or mice subjected to immunosuppression, such as corticosteroids or anti-cytokine biologic therapies, are susceptible to mucosal infections by the commensal fungus Candida albicans. Recently it has become evident that the Th17/IL-17 axis is ess
Externí odkaz:
https://doaj.org/article/d2fc60e98522479b819096b266c7fb45
Autor:
Allen W Ho, Abhishek V Garg, Leticia Monin, Michelle R Simpson-Abelson, Lauren Kinner, Sarah L Gaffen
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70168 (2013)
IL-17 is the founding member of a family of cytokines and receptors with unique structures and signaling properties. IL-17 is the signature cytokine of Th17 cells, a relatively new T cell population that promotes inflammation in settings of infection
Externí odkaz:
https://doaj.org/article/14d65c6d385c40d682cec05f64ff057e
Autor:
Amanda C. Poholek, Michelle R. Simpson-Abelson, Ansuman Chattopadhyay, Sarah L. Gaffen, Mandy J. McGeachy, J. Agustin Cruz, Gerard Hernandez-Mir, Erin E. Childs
Publikováno v:
Cytokine. 92:24-32
The CCAAT/Enhancer Binding Protein β (C/EBPβ) transcription factor is activated by multiple inflammatory stimuli, including IL-17 and LPS, and C/EBPβ itself regulates numerous genes involved in inflammation. However, the role of C/EBPβ in driving
Autor:
Nico Ghilardi, Shrinivas Bishu, Heather R. Conti, Nydiaris Hernández-Santos, Anna J. Mamo, Sarah L. Gaffen, Michelle R. Simpson-Abelson, Anna R. Huppler
Publikováno v:
Infection and Immunity. 82:1173-1180
Oropharyngeal candidiasis (OPC [thrush]) is an opportunistic infection caused by the commensal fungus Candida albicans . OPC is common in individuals with HIV/AIDS, infants, patients on chemotherapy, and individuals with congenital immune defects. Im
Autor:
Ulrich Siebenlist, Heather R. Conti, Abhishek V. Garg, Anna R. Huppler, David Artis, Michelle R. Simpson-Abelson, Shrinivas Bishu, Gregory A. Gibson, Simon C. Watkins, Lisa C. Osborne, Natasha Whibley, Mandy J. McGeachy, Anna J. Mamo, Nydiaris Hernández-Santos, Sarah L. Gaffen, Alanna C. Peterson, Nico Ghilardi, Lucas Brane
Publikováno v:
The Journal of Experimental Medicine
Conti et al. show that IL-17 is produced by tongue-resident populations of γδ T cells and nTh17 cells in response to oropharyngeal candidiasis in mice.
Oropharyngeal candidiasis (OPC) is an opportunistic fungal infection caused by Candida albi
Oropharyngeal candidiasis (OPC) is an opportunistic fungal infection caused by Candida albi
Autor:
Viktoria Gontcharova, Cecile Chartier, Michelle R. Simpson-Abelson, Sam Suzuki, Michelle A. Blaskovich
Publikováno v:
Cancer Research. 79:LB-069
Adoptive cell transfer utilizing tumor-infiltrating lymphocytes (TIL) is recognized as an effective treatment in metastatic melanoma and other solid tumors eliciting durable and complete responses in heavily pretreated patients, presumably by targeti
Autor:
Heather K. Lehman, Michelle R. Simpson-Abelson, Richard B. Bankert, Raymond J. Kelleher, Joel M. Bernstein, Thomas F. Conway
Publikováno v:
Journal of the Association for Research in Otolaryngology. 13:423-435
A majority of T cells from chronic inflammatory tissues derived from patients with nasal polyposis were found to express an effector memory phenotype. We report here that these memory T cells failed to activate NF-κB in response to TCR stimulation b
Autor:
Raymond J. Kelleher, Richard B. Bankert, Michelle R. Simpson-Abelson, Jennifer L. Barnas, Stephen Brooks
Publikováno v:
The Journal of Immunology. 185:2681-2692
Fibroblasts are a dominant cell type in most human solid tumors. The possibility that fibroblasts have the capacity to interact with and modulate the function of tumor-associated T lymphocytes makes them a potential therapeutic target. To address thi
Autor:
Leonard D. Shultz, Thomas F. Conway, Hiroshi Takita, Gregory F Sonnenberg, Michelle R. Simpson-Abelson, Sandra J. Yokota, Maurice Barcos, Richard B. Bankert, Raymond J. Kelleher
Publikováno v:
The Journal of Immunology. 180:7009-7018
Non-disrupted pieces of primary human lung tumor implanted into NOD-scid IL2Rγnull mice consistently result in successful xenografts in which tissue architecture, including tumor-associated leukocytes, stromal fibroblasts, and tumor cells are preser
Autor:
Michael R. Nazareth, Michelle R. Simpson-Abelson, Richard B. Bankert, Lori Broderick, Sandra J. Yokota, Raymond J. Kelleher
Publikováno v:
The Journal of Immunology. 178:5552-5562
The tumor microenvironment of human non-small cell lung cancer (NSCLC) is composed largely of stromal cells, including fibroblasts, yet these cells have been the focus of few studies. In this study, we established stromal cell cultures from primary N