Molecular phylogenetics uncovers two new species in the genus Phyllobates (Anura, Dendrobatidae): the terrible frog gets two new sisters

Autor: Adolfo Amézquita, Fernando Vargas-Salinas, Iván Ramos, Pablo Palacios-Rodríguez, Erika Nathalia Salazar, Michelle Quiroz, Wilmar Bolívar, Diana M. Galindo-Uribe, Luis A. Mazariegos-H

Publikováno v: ZooKeys, Vol 1212, Iss , Pp 217-240 (2024)

True poison-dart frogs (Phyllobates, Dendrobatidae) evolved the ability to secrete batrachotoxins, the most powerful alkaloids known to date. The genus comprises five species whose systematics, at first glance, appeared clear. The most derived clade

Externí odkaz: https://doaj.org/article/4d52c3feeecd4bd48ab54db43929d154

A new synthesis of biologically active pyrroles: Formal synthesis of pentabromopseudilin, bimetopyrol, and several antitubercular agents

Autor: Biling Chen, Sasan Karimi, Shuai Ma, William F. Berkowitz, Keith Ramig, Edyta M. Greer, Gopal Subramaniam, Michelle Qu, David J. Szalda, Michelle C. Neary

Publikováno v: Journal of Heterocyclic Chemistry. 57:327-336

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::656577b0b84879963b7913adee4141cc
https://doi.org/10.1002/jhet.3780

Ongoing harlequin toad declines suggest the amphibian extinction crisis is still an emergency

Autor: Stefan Lötters, Amadeus Plewnia, Alessandro Catenazzi, Kelsey Neam, Andrés R. Acosta-Galvis, Yesenia Alarcon Vela, Joshua P. Allen, Juan O. Alfaro Segundo, Ana de Lourdes Almendáriz Cabezas, Gilbert Alvarado Barboza, Kleiton R. Alves-Silva, Marvin Anganoy-Criollo, Ernesto Arbeláez Ortiz, Jackeline D. Arpi Lojano, Alejandro Arteaga, Onil Ballestas, Diego Barrera Moscoso, José D. Barros-Castañeda, Abel Batista, Manuel H. Bernal, Esteban Betancourt, Youszef Oliveira da Cunha Bitar, Philipp Böning, Laura Bravo-Valencia, José F. Cáceres Andrade, Diego Cadenas, Juan Carlos Chaparro Auza, Giovanni A. Chaves-Portilla, Germán Chávez, Luis A. Coloma, Claudia F. Cortez-Fernandez, Elodie A. Courtois, Jaime Culebras, Ignacio De la Riva, Vladimir Diaz, Luis C. Elizondo Lara, Raffael Ernst, Sandra V. Flechas, Thibaut Foch, Antoine Fouquet, Carmen Z. García Méndez, Juan Elias García-Pérez, Diego A. Gómez-Hoyos, Samuel C. Gomides, Jorge Guerrel, Brian Gratwicke, Juan M. Guayasamin, Edgardo Griffith, Valia Herrera-Alva, Roberto Ibáñez, Carlos Iván Idrovo, Andrés Jiménez Monge, Rafael F. Jorge, Alisha Jung, Blake Klocke, Margarita Lampo, Edgar Lehr, Carrie H. R. Lewis, Erik D. Lindquist, Yeny R. López-Perilla, Glib Mazepa, Guido F. Medina-Rangel, Andrés Merino Viteri, Kevin Mulder, Mauricio Pacheco-Suarez, Andry Pereira-Muñoz, José Luis Pérez-González, Maria Alejandra Pinto Erazo, Adolfo Gustavo Pisso Florez, Marcos Ponce, Vicky Poole, Amanda B. Quezada Riera, Aarón J. Quiroz, Michelle Quiroz-Espinoza, Alejandro Ramírez Guerra, Juan P. Ramírez, Steffen Reichle, Hugo Reizine, Mauricio Rivera-Correa, Bernardo Roca-Rey Ross, Andrés Rocha-Usuga, Miguel Trefaut Rodrigues, Sintana Rojas Montaño, Daniela C. Rößler, Luis Alberto Rueda Solano, Celsa Señaris, Alexander Shepack, Fausto R. Siavichay Pesántez, Anton Sorokin, Andrea Terán-Valdez, Grecia Torres-Ccasani, Pablo C. Tovar-Siso, Lina M. Valencia, David A. Velásquez-Trujillo, Michael Veith, Pablo J. Venegas, Jeferson Villalba-Fuentes, Rudolf von May, Juan F. Webster Bernal, Enrique La Marca

Publikováno v: Communications Earth & Environment, Vol 4, Iss 1, Pp 1-8 (2023)

Abstract Biodiversity loss is extreme in amphibians. Despite ongoing conservation action, it is difficult to determine where we stand in overcoming their extinction crisis. Among the most threatened amphibians are the 131 Neotropical harlequin toads.

Externí odkaz: https://doaj.org/article/f59319ec0349480b99c54a0bfcd9a4de

Investigating the value of glucodensity analysis of continuous glucose monitoring data in type 1 diabetes: an exploratory analysis

Autor: Elvis Han Cui, Allison B. Goldfine, Michelle Quinlan, David A. James, Oleksandr Sverdlov

Publikováno v: Frontiers in Clinical Diabetes and Healthcare, Vol 4 (2023)

IntroductionContinuous glucose monitoring (CGM) devices capture longitudinal data on interstitial glucose levels and are increasingly used to show the dynamics of diabetes metabolism. Given the complexity of CGM data, it is crucial to extract importa

Externí odkaz: https://doaj.org/article/0b9d0c6469524d3d96058b394533bb20

Pharmacokinetics of asciminib in the presence of CYP3A or P‐gp inhibitors, CYP3A inducers, and acid‐reducing agents

Autor: Matthias Hoch, Felix Huth, Masahiko Sato, Tirtha Sengupta, Michelle Quinlan, Stephanie Dodd, Shruti Kapoor, Florence Hourcade‐Potelleret

Publikováno v: Clinical and Translational Science, Vol 15, Iss 7, Pp 1698-1712 (2022)

Abstract Asciminib is a first‐in‐class inhibitor of BCR::ABL1, specifically targeting the ABL myristoyl pocket. Asciminib is a substrate of CYP3A4 and P‐glycoprotein (P‐gp) and possesses pH‐dependent solubility in aqueous solution. This rep

Externí odkaz: https://doaj.org/article/5df116dd14d544be888ed9ac77e9a8fa