Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michelle Pusey"'
Autor:
Yaoyu Chen, Margaret Favata, Michelle Pusey, Jun Li, Yvonne Lo, Min Ye, Richard Wynn, Xiaozhao Wang, Wenqing Yao, Yingnan Chen
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-9 (2020)
Abstract Background The MER signaling pathway represents an attractive therapeutic target for human cancers. Growth arrest–specific protein 6 (GAS6)–induced MER phosphorylation is often unstable and difficult to detect without pervanadate pretrea
Externí odkaz:
https://doaj.org/article/871c0005c54e4b25b13d6257133f0ae7
Autor:
Lyndi M. Rice, Jing-Jing Yang, Mariya Nestor, Aishwarya Bhaskar, Sophie Bail, Amy Werda, Michelle Pusey, Ewa Wandzioch
PDF file - 340K, Table S1. siRNA and shRNA sequences targeting the gene PPME1, which codes for PME-1 protein. Table S2. Tumor and normal adjacent tissue (NAT) matched pairs were purchased from Proteogenex.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd51a4ea07cca8d8e067b9a27cacda4
https://doi.org/10.1158/0008-5472.22398746
https://doi.org/10.1158/0008-5472.22398746
Autor:
Michelle Pusey, Jun Li, Yaoyu Chen, Wenqing Yao, Yingnan Chen, Yvonne Lo, Min Ye, Xiaozhao Wang, Margaret F. Favata, Richard Wynn
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-9 (2020)
Biomarker Research
Biomarker Research
Background The MER signaling pathway represents an attractive therapeutic target for human cancers. Growth arrest–specific protein 6 (GAS6)–induced MER phosphorylation is often unstable and difficult to detect without pervanadate pretreatment in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95900ac0c438c15a0be8c0e9f35928a
https://doi.org/10.1186/s40364-020-0184-9
https://doi.org/10.1186/s40364-020-0184-9
Autor:
Michael R. Witten, Michelle Pusey, Yaoyu Chen, Kanishk Kapilashrami, Cheng-Tsung Lai, Wenqing Yao, Liangxing Wu, Karen Gallagher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 55:128452
Activin receptor-like kinase 2 (ALK2) has been implicated as a key target in multiple rare diseases. Herein, we describe the design of a novel bicyclic lactam series of potent and selective ALK2 inhibitors. This manuscript details an improvement in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d220a5fc625cc8c3536f5873f311aff3
https://doi.org/10.1016/j.bmcl.2021.128452
https://doi.org/10.1016/j.bmcl.2021.128452
Autor:
Jing-Jing Yang, Mariya Nestor, Sophie Bail, Michelle Pusey, Yan Xu, Olesia Buiakova, Lyndi M. Rice
Publikováno v:
Tumor Biology. 37:11835-11842
Protein methylesterase 1 (PME-1) promotes cancerous phenotypes through the demethylation and inactivation of protein phosphatase 2A. We previously demonstrated that PME-1 overexpression promotes Akt, ERK, and may promote Wnt signaling and increases t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79e35eb6834a912034a8e677ff2ba2f
https://doi.org/10.1007/s13277-016-5036-8
https://doi.org/10.1007/s13277-016-5036-8
Autor:
Robert Collins, Sharon Diamond, Yaoyu Chen, Michelle Pusey, Swamy Yeleswaram, Luping Lin, Kevin Bowman, Susan Wee, Sunkyu Kim, Matthew C. Stubbs, Kanishk Kapilashrami, Pramod Thekkat, Yingnan Chen, Holly Koblish, Yan-ou Yang, Mark Rupar, Xiaoming Wen
Publikováno v:
Blood. 136:52-52
A significant population of patients with myelofibrosis (MF) develop anemia and either require red blood cell (RBC) transfusions or have an inadequate response to the currently available therapies and become transfusion-dependent. In patients with MF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a356339d16d96d063dfcbda4adf5ae
https://doi.org/10.1182/blood-2020-136138
https://doi.org/10.1182/blood-2020-136138
Autor:
Christine Gardiner, Jonathan Rios-Doria, Sunkyu Kim, Hui Wang, Yaoyu Chen, Elham Behshad, Yingnan Chen, Maryanne Covington, Alexander Sokolsky, Wenqing Yao, Kerri Lasky, Min Ye, Pramod Thekkat, Holly Koblish, Oleg Vechorkin, Luping Lin, Kristine Stump, Michelle Pusey, Karen Gallagher, Patricia Conlen, Mark Rupar
Publikováno v:
Cancer Research. 80:4513-4513
Antigen recognition and T-cell receptor (TCR) activation are fundamental processes that drive anti-tumor T cell responses. HPK1 has been identified as a negative regulator of TCR activation, as well as BCR activation, and is a potential anticancer ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bdd5cffe9cccbde9b7d9626f95c007b
https://doi.org/10.1158/1538-7445.am2020-4513
https://doi.org/10.1158/1538-7445.am2020-4513
Autor:
Natalie Barnett-Bernodat, Joseph T. Nickels, Rajash Pallai, Aishwarya Bhaskar, Christina Gallo-Ebert, Lyndi M. Rice, Michelle Pusey
Publikováno v:
Tumor Biology. 36:6383-6390
Using yeast two-hybrid analysis, we identified several novel protein interactions for the oncoprotein Cancerous Inhibitor of PP2A (CIP2A) and confirmed a subset of these interactions in human cancer cell lines. Analysis of the interaction in prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe282de6ea9942ec316c43f34f561f6
https://doi.org/10.1007/s13277-015-3326-1
https://doi.org/10.1007/s13277-015-3326-1
Publikováno v:
Cancer Cell & Microenvironment.
Protein phosphatase 2A (PP2A) is a heterotrimeric serine/threonine phosphatase that has many inhibitory roles in cell proliferation and metastasis and promotes tumor suppressor activity. Protein methylesterase 1 (PME-1) inhibits PP2A through the remo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f04708d48e80293bc6d0705c744acb4
https://doi.org/10.14800/ccm.299
https://doi.org/10.14800/ccm.299
Autor:
Ewa Wandzioch, Amy Werda, Sophie Bail, Michelle Pusey, Aishwarya Bhaskar, Lyndi M. Rice, Jing-Jing Yang, Mariya Nestor
Publikováno v:
Cancer research. 74(16)
Protein phosphatase 2A (PP2A) negatively regulates tumorigenic signaling pathways, in part, by supporting the function of tumor suppressors like p53. The PP2A methylesterase PME-1 limits the activity of PP2A by demethylating its catalytic subunit. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ed260228cfeee73aec560123fb692f
https://pubmed.ncbi.nlm.nih.gov/24928782
https://pubmed.ncbi.nlm.nih.gov/24928782