Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michelle Pirruccello-Straub"'
Autor:
Shaun M. Cote, Gregory J. Carven, Justin W. Jackson, Stefan Wawersik, Michelle Pirruccello-Straub
Publikováno v:
Slas Discovery
Myostatin, a member of the transforming growth factor β (TGFβ) superfamily, is a key regulator of skeletal muscle mass and a therapeutic target for muscle wasting diseases. We developed a human monoclonal antibody, SRK-015, that selectively binds t
Autor:
A. Donovan, Capili Allan, K. J. Turner, Michelle Pirruccello-Straub, K. Long, W. McConaughy, N. K. Mahanthappa, Stefan Wawersik, Gregory J. Carven, L. Salta, C. Boston, M. T. Webster, Justin W. Jackson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Many growth factors are intimately bound to the extracellular matrix, with regulated processing and release leading to cellular stimulation. Myostatin and GDF11 are closely related members of the TGFβ family whose activation requires two proteolytic
Autor:
Roxana E. Iacob, Timothy A. Springer, William K. Mcconaughy, Michelle Pirruccello-Straub, Yang Su, Viet Q. Le, Bo Zhao, Yuan Tian, Justin W. Jackson, John R. Engen
Publikováno v:
The EMBO journal. 37(3)
Growth differentiation factor 8 (GDF8)/myostatin is a latent TGF-β family member that potently inhibits skeletal muscle growth. Here, we compared the conformation and dynamics of precursor, latent, and Tolloid-cleaved GDF8 pro-complexes to understan
Autor:
Viet Q. Le, Yang Su, Justin W. Jackson, Bo Zhao, William K. Mcconaughy, Yuan Tian, Michelle Pirruccello-Straub, Timothy A. Springer, John R. Engen, Roxana E. Iacob
Growth differentiation factor 8 (GDF8)/Myostatin is a latent TGFβ family member that potently inhibits skeletal muscle growth. Here, we compared the conformation and dynamics of precursor, latent, and Tolloidcleaved GDF8 procomplexes to unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658d6eeb557c098b0840d77cb37b2d64