Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michelle Pirruccello"'
Autor:
Nabanita De, Michelle Pirruccello, Petya Violinova Krasteva, Narae Bae, Rahul Veera Raghavan, Holger Sondermann
Publikováno v:
PLoS Biology, Vol 6, Iss 3, p e67 (2008)
Environmental signals that trigger bacterial pathogenesis and biofilm formation are mediated by changes in the level of cyclic dimeric guanosine monophosphate (c-di-GMP), a unique eubacterial second messenger. Tight regulation of cellular c-di-GMP co
Externí odkaz:
https://doaj.org/article/b59e32dc054d4b118d0db4626bdd41d9
Autor:
Shaun M. Cote, Gregory J. Carven, Justin W. Jackson, Stefan Wawersik, Michelle Pirruccello-Straub
Publikováno v:
Slas Discovery
Myostatin, a member of the transforming growth factor β (TGFβ) superfamily, is a key regulator of skeletal muscle mass and a therapeutic target for muscle wasting diseases. We developed a human monoclonal antibody, SRK-015, that selectively binds t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2da6b688ca3284cd87c3692ac3a39d
https://doi.org/10.1177/2472555219860779
https://doi.org/10.1177/2472555219860779
Autor:
Alexandre, Luscher, Florian, Fröhlich, Caroline, Barisch, Clare, Littlewood, Joe, Metcalfe, Florence, Leuba, Anita, Palma, Michelle, Pirruccello, Gianni, Cesareni, Massimiliano, Stagi, Tobias C, Walther, Thierry, Soldati, Pietro, De Camilli, Laura E, Swan
Publikováno v:
Molecular Biology of the Cell
Mutations of the inositol 5-phosphatase OCRL cause Lowe syndrome (LS), characterized by congenital cataract, low IQ, and defective kidney proximal tubule resorption. A key subset of LS mutants abolishes OCRL’s interactions with endocytic adaptors c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4861335082652afbe83bd12b58b3607
https://pubmed.ncbi.nlm.nih.gov/31216233
https://pubmed.ncbi.nlm.nih.gov/31216233
Autor:
Joe Metcalfe, Thierry Soldati, Anita Palma, Laura E. Swan, Tobias C. Walther, Florian Fröhlich, Pietro De Camilli, Michelle Pirruccello, Clare Littlewood, Gianni Cesareni, Caroline Barisch, Massimiliano Stagi, Florence Leuba, Alexandre Luscher
Publikováno v:
Molecular Biology of the Cell, Vol. 30, No 17 (2019) pp. 2268-2282
SummaryMutations of the inositol 5-phosphatase OCRL cause Lowe Syndrome (LS), characterized by congenital cataract, low IQ and defective kidney proximal tubule resorption. A key subset of LS mutants abolishes OCRL’s interactions with endocytic adap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c8459ff0697f2a0eda8f551cee73b3
https://doi.org/10.1101/616664
https://doi.org/10.1101/616664
Autor:
A. Donovan, Capili Allan, K. J. Turner, Michelle Pirruccello-Straub, K. Long, W. McConaughy, N. K. Mahanthappa, Stefan Wawersik, Gregory J. Carven, L. Salta, C. Boston, M. T. Webster, Justin W. Jackson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Many growth factors are intimately bound to the extracellular matrix, with regulated processing and release leading to cellular stimulation. Myostatin and GDF11 are closely related members of the TGFβ family whose activation requires two proteolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de1d7579c7a15a828914f93562cc89b
http://europepmc.org/articles/PMC5797207
http://europepmc.org/articles/PMC5797207
Autor:
Roxana E. Iacob, Timothy A. Springer, William K. Mcconaughy, Michelle Pirruccello-Straub, Yang Su, Viet Q. Le, Bo Zhao, Yuan Tian, Justin W. Jackson, John R. Engen
Publikováno v:
The EMBO journal. 37(3)
Growth differentiation factor 8 (GDF8)/myostatin is a latent TGF-β family member that potently inhibits skeletal muscle growth. Here, we compared the conformation and dynamics of precursor, latent, and Tolloid-cleaved GDF8 pro-complexes to understan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e934f647cb1fe2c6300575fe2081ba9a
https://pubmed.ncbi.nlm.nih.gov/29343545
https://pubmed.ncbi.nlm.nih.gov/29343545
Autor:
Viet Q. Le, Yang Su, Justin W. Jackson, Bo Zhao, William K. Mcconaughy, Yuan Tian, Michelle Pirruccello-Straub, Timothy A. Springer, John R. Engen, Roxana E. Iacob
Growth differentiation factor 8 (GDF8)/Myostatin is a latent TGFβ family member that potently inhibits skeletal muscle growth. Here, we compared the conformation and dynamics of precursor, latent, and Tolloidcleaved GDF8 procomplexes to unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658d6eeb557c098b0840d77cb37b2d64
Autor:
Yasunori Saheki, Nica Borgese, Francesca Giordano, Sara Francesca Colombo, Sviatoslav N. Bagriantsev, Elena O. Gracheva, Pietro De Camilli, Michelle Pirruccello, Olof Idevall-Hagren, Ira Milosevic
Publikováno v:
Cell. 153:1494-1509
Most available information on endoplasmic reticulum (ER)-plasma membrane (PM) contacts in cells of higher eukaryotes concerns proteins implicated in the regulation of Ca(2+) entry. However, growing evidence suggests that such contacts play more gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499af542eeadd018dd5a553a2d95b16a
https://doi.org/10.1016/j.cell.2013.05.026
https://doi.org/10.1016/j.cell.2013.05.026
Autor:
Sang Yoon Lee, Guanghou Shui, Pietro De Camilli, Lukas B. Tanner, Fubito Nakatsu, Jeremy M. Baskin, Mingming Hao, Markus R. Wenk, Jeeyun Chung, Nicholas T. Ingolia, Michelle Pirruccello
Publikováno v:
The Journal of Cell Biology, vol 199, iss 6
The Journal of cell biology, vol 199, iss 6
The Journal of Cell Biology
The Journal of cell biology, vol 199, iss 6
The Journal of Cell Biology
PI4KIIIα is targeted to the plasma membrane via an evolutionarily conserved complex comprised of EFR3 and TTC7 to control PtdIns4P synthesis and the selective enrichment of PtdIns(4,5)P2 in this membrane.
Plasma membrane phosphatidylinositol (P
Plasma membrane phosphatidylinositol (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b599c3d6f9979a2b9c1cdb76d819d3
https://doi.org/10.1083/jcb.201206095
https://doi.org/10.1083/jcb.201206095
Publikováno v:
Trends in Biochemical Sciences. 37:134-143
The precise regulation of phosphoinositide lipids in cellular membranes is critical for cellular survival and function. Inositol 5-phosphatases have been implicated in a variety of disorders, including various cancers, obesity, Type II diabetes, neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fd5cac1e8449a613663d636ee61e10
https://doi.org/10.1016/j.tibs.2012.01.002
https://doi.org/10.1016/j.tibs.2012.01.002