Methylome and transcriptome maps of human visceral and subcutaneous adipocytes reveal key epigenetic differences at developmental genes

Autor: Helen L. Lutgers, Brodie Sutcliffe, Rosanna Arnoldy, Clare Stirzaker, Susan J. van Dijk, Shalima S. Nair, Michael M. Swarbrick, Reginald V. Lord, Firoz Anwar, Peter L. Molloy, Elena Zotenko, Jenny Z. Song, Wenjia Qu, Susan J. Clark, Stephen T Bradford, Denis C. Bauer, Michael Buckley, Michelle Peranec, Hilal Varinli, Katherine Samaras, Aaron L. Statham, Julius Z. H. von Martels, Jason P. Ross, Madhavi P. Maddugoda, Timothy J. Peters, Hugh J. French

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, 9:9511. Nature Publishing Group
Scientific Reports

Adipocytes support key metabolic and endocrine functions of adipose tissue. Lipid is stored in two major classes of depots, namely visceral adipose (VA) and subcutaneous adipose (SA) depots. Increased visceral adiposity is associated with adverse hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab52944b338d30ee88efb302b757c62
https://doi.org/10.1038/s41598-019-45777-w

R270C polymorphism leads to loss of function of the canine P2X7 receptor

Autor: Rachael Bartlett, Vanessa Sluyter, Iman Jalilian, Aine Seavers, Mark Dowton, Tahani Bakhsh, Mari Spildrejorde, Leanne Stokes, Michelle Peranec, Amanda Skora, Ronald Sluyter, Belinda L. Curtis, Jason D. McArthur, Kristen K. Skarratt

Publikováno v: Physiological genomics. 46(14)

The relative function of the P2X7 receptor, an ATP-gated ion channel, varies between humans due to polymorphisms in the P2RX7 gene. This study aimed to assess the functional impact of P2X7 variation in a random sample of the canine population. Blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8ed8db1eef70c1f02abc38257b112a
https://pubmed.ncbi.nlm.nih.gov/24824213

Mucosal‐associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy‐related colitis in a pathology distinct from ulcerative colitis.

Autor: Sasson, S. C.¹ (AUTHOR) sarah.sasson@ndm.ox.ac.uk, Zaunders, J. J.² (AUTHOR), Nahar, K.³ (AUTHOR), Munier, C. M. L.⁴ (AUTHOR), Fairfax, B. P.^5,6,7 (AUTHOR), Olsson‐Brown, A.⁸ (AUTHOR), Jolly, C.⁸ (AUTHOR), Read, S. A.^9,10 (AUTHOR), Ahlenstiel, G.^9,11 (AUTHOR), Palendira, U.¹² (AUTHOR), Scolyer, R. A.^3,13 (AUTHOR), Carlino, M. S.^3,14 (AUTHOR), Payne, M. J.⁵ (AUTHOR), Cheung, V. T. F.¹ (AUTHOR), Gupta, T.^1,7 (AUTHOR), Klenerman, P.^1,15 (AUTHOR), Long, G. V.^3,16 (AUTHOR), Brain, O.^1,17 (AUTHOR), Menzies, A. M.^3,16 (AUTHOR), Kelleher, A. D.^2,4 (AUTHOR)

Publikováno v: Clinical & Experimental Immunology. Dec2020, Vol. 202 Issue 3, p335-352. 18p. 1 Color Photograph, 7 Charts, 3 Graphs.

Association Between Circulating Tumor DNA and Pseudoprogression in Patients With Metastatic Melanoma Treated With Anti–Programmed Cell Death 1 Antibodies.

Autor: Lee, Jenny H., Long, Georgina V., Menzies, Alexander M., Lo, Serigne, Guminski, Alexander, Whitbourne, Kataraina, Peranec, Michelle, Scolyer, Richard, Kefford, Richard F., Rizos, Helen, Carlino, Matteo S.

Publikováno v: JAMA Oncology; May2018, Vol. 4 Issue 5, p717-721, 5p