Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michelle Pacholec"'
Autor:
Jane M. Withka, David A. Griffith, John E. Bleasdale, Declan Flynn, Brian J. Stockman, Pat Loulakis, Kay Ahn, Xiayang Qiu, Jessica Ward, David Cunningham, Venkataraman Thanabal, Michelle Pacholec, Alison H. Varghese, Brandon Pabst, Boris A. Chrunyk, Robert S. Garofalo, Matt Griffor
Publikováno v:
Journal of Biological Chemistry. 285:8340-8351
Sirtuins catalyze NAD(+)-dependent protein deacetylation and are critical regulators of transcription, apoptosis, metabolism, and aging. There are seven human sirtuins (SIRT1-7), and SIRT1 has been implicated as a key mediator of the pathways downstr
Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol
Publikováno v:
Organicbiomolecular chemistry. 5(11)
Herein we report the first biochemical characterization of an enzyme involved in the biosynthesis of chloramphenicol that provides new insights into the origins of the antibiotic.
Publikováno v:
Biochemistry. 44(45)
During the biosynthesis of the streptomycete aminocoumarin antibiotics novobiocin and the dimeric coumermycin A(1), the bicyclic coumarin scaffold is C-methylated adjacent to the phenolic oxygen. The SAM-dependent C-methyltransferases NovO and CouO h
Publikováno v:
Biochemistry. 44(38)
The bicyclic coumarin ring in the aminocoumarin natural product antibiotics that target bacterial DNA gyrase is assembled from tyrosine by nonribosomal peptide synthetase logic. Tyrosine has previously been shown to be activated and installed as a ph
Autor:
Christopher T. Walsh, Caren L. Freel Meyers, Markus Oberthür, Michelle Pacholec, Daniel Kahne
Publikováno v:
Biochemistry. 44(12)
Simocyclinone D(8) consists of an anguicycline C-glycoside tethered by a tetraene diester linker to an aminocoumarin. Unlike the antibiotics novobiocin, clorobiocin, and coumermycin A(1), the phenolic hydroxyl group of the aminocoumarin in simocyclin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(27)
The tripartite scaffold of the natural product antibiotic novobiocin is assembled by the tandem action of novobiocin ligase (NovL) and novobiocic acid noviosyl transferase (NovM). The noviosyl ring of the tripartite scaffold is further decorated by a
Publikováno v:
ChemInform. 34
[structure: see text] A chemoenzymatic synthesis was described to prepare proposed oxidation-cyclization-methylation intermediates of the coumarin antibiotic biosynthetic pathway. The successful synthesis of these fragile molecules relies heavily on