Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Michelle P, Christie"'
Autor:
Hunter L. Abrahamsen, Tristan C. Sanford, Casie E. Collamore, Bronte A. Johnstone, Michael J. Coyne, Leonor García-Bayona, Michelle P. Christie, Jordan C. Evans, Allison J. Farrand, Katia Flores, Craig J. Morton, Michael W. Parker, Laurie E. Comstock, Rodney K. Tweten
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cholesterol-dependent cytolysins (CDCs) comprise a large family of pore-forming toxins produced by Gram-positive bacteria, which are used to attack eukaryotic cells. Here, we functionally characterize a family of 2-component CDC-like (CDCL)
Externí odkaz:
https://doaj.org/article/fa81631103bf486aa966a456bbef1768
Autor:
KM Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Böcking
Publikováno v:
eLife, Vol 13 (2024)
The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here, we investigate the effect of lenacapavir on HIV capsid stabil
Externí odkaz:
https://doaj.org/article/08ba42401fe84baebde255dedc84b832
Autor:
Conall McGuinness, James C Walsh, Charles Bayly-Jones, Michelle A Dunstone, Michelle P Christie, Craig J Morton, Michael W Parker, Till Böcking
Publikováno v:
eLife, Vol 11 (2022)
The cholesterol-dependent cytolysin perfringolysin O (PFO) is secreted by Clostridium perfringens as a bacterial virulence factor able to form giant ring-shaped pores that perforate and ultimately lyse mammalian cell membranes. To resolve the kinetic
Externí odkaz:
https://doaj.org/article/9c52c20469604be898a9fcf4065fd2d3
Autor:
Jordan C. Evans, Bronte A. Johnstone, Sara L. Lawrence, Craig J. Morton, Michelle P. Christie, Michael W. Parker, Rodney K. Tweten
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT The cholesterol-dependent cytolysins (CDCs) are bacterial, β-barrel, pore-forming toxins. A central enigma of the pore-forming mechanism is how completion of the prepore is sensed to initiate its conversion to the pore. We identified a moti
Externí odkaz:
https://doaj.org/article/c68956bf53bd4654a2ba9c2e4b08d948
Autor:
Bronte A. Johnstone, Riya Joseph, Michelle P. Christie, Craig J. Morton, Conall McGuiness, James C. Walsh, Till Böcking, Rodney K. Tweten, Michael W. Parker
Publikováno v:
IUBMB Life. 74:1169-1179
The cholesterol-dependent cytolysins (CDCs) are a major family of bacterial pore-forming proteins secreted as virulence factors by Gram-positive bacterial species. CDCs are produced as soluble, monomeric proteins that bind specifically to cholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b139d738d4fd5f1257f096aba544651
https://doi.org/10.1002/iub.2661
https://doi.org/10.1002/iub.2661
Autor:
Kristin R. Wade, Sara L. Lawrence, Allison J. Farrand, Eileen M. Hotze, Michael J. Kuiper, Michael A. Gorman, Michelle P. Christie, Santosh Panjikar, Craig J. Morton, Michael W. Parker, Rodney K. Tweten
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebrate niches, which suggests that they have evolved to function under widely different environmental conditions. U
Externí odkaz:
https://doaj.org/article/7bf35b5ddc6847bfb07b9a7eda692855
Autor:
K.M. Rifat Faysal, Nadine Renner, Chantal L Marquez, Vaibhav Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart Grant Turville, Leo James, Greg J Towers, David A Jacques, Till Boecking
The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here we investigate the effect of Lenacapavir on HIV capsid stabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70a6ad00254f752272f276917526c7f
https://doi.org/10.1101/2022.09.21.508807
https://doi.org/10.1101/2022.09.21.508807
Autor:
Michelle P Christie, Shu-Hong Hu, Andrew E Whitten, Asma Rehman, Russell J Jarrott, Gordon J King, Brett M Collins, Jennifer L Martin
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187302 (2017)
The efficient delivery of cellular cargo relies on the fusion of cargo-carrying vesicles with the correct membrane at the correct time. These spatiotemporal fusion events occur when SNARE proteins on the vesicle interact with cognate SNARE proteins o
Externí odkaz:
https://doaj.org/article/e1d5bce38ddc4d1b98de692d745175e8
Autor:
Asma Rehman, Shu-Hong Hu, Zakir Tnimov, Andrew E Whitten, Gordon J King, Russell J Jarrott, Suzanne J Norwood, Kirill Alexandrov, Brett M Collins, Michelle P Christie, Jennifer L Martin
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183366 (2017)
Vesicular transport of cellular cargo requires targeted membrane fusion and formation of a SNARE protein complex that draws the two apposing fusing membranes together. Insulin-regulated delivery and fusion of glucose transporter-4 storage vesicles at
Externí odkaz:
https://doaj.org/article/b085b7d07209489292faba0427e15430
Autor:
James C Walsh, Conall McGuinness, Charles Bayly-Jones, Michelle A Dunstone, Michelle P Christie, Craig J Morton, Michael W Parker, Till Böcking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f7d20f9861e99421b86c9fe3c05496
https://doi.org/10.7554/elife.74901.sa2
https://doi.org/10.7554/elife.74901.sa2