Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes

Autor: Thomas H Julian, Nicholas Glascow, A Dylan Fisher Barry, Tobias Moll, Calum Harvey, Yann C Klimentidis, Michelle Newell, Sai Zhang, Michael P Snyder, Johnathan Cooper-Knock, Pamela J Shaw

Publikováno v: EBioMedicine, Vol 68, Iss , Pp 103397- (2021)

Background: Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease. ALS is determined by gene-environment interactions and improved understanding of these interactions may lead to effective personalised medicine. The rol

Externí odkaz: https://doaj.org/article/b14f3c3d161c4cbdb4b00a743b2e8d20

Identification of genetic loci simultaneously associated with multiple cardiometabolic traits

Autor: Alexis C. Wood, Amit Arora, Michelle Newell, Victoria L. Bland, Jin Zhou, Nicola Pirastu, Jose M. Ordovas, Yann C. Klimentidis

Publikováno v: Wood, A C, Arora, A, Newell, M, Bland, V L, Zhou, J, Pirastu, N, Ordovas, J M & Klimentidis, Y C 2022, ' Identification of genetic loci simultaneously associated with multiple cardiometabolic traits ', Nutrition, Metabolism and Cardiovascular Diseases, vol. 32, no. 4, pp. 1027-1034 . https://doi.org/10.1016/j.numecd.2022.01.002
Nutr Metab Cardiovasc Dis

Background and AimsCardiometabolic disorders (CMD) arise from a constellation of features such as increased adiposity, hyperlipidemia, hypertension and compromised glucose control. Many genetic loci have shown associations with individual CMD-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa8ebf1e6e5a094873a9521606f1634
https://doi.org/10.1016/j.numecd.2022.01.002

1138-P: Impact of Continuous Glucose Monitoring (CGM) on Glycemic Control and Acute Complications in Type 2 Diabetes (T2D) in the Veterans Health Administration (VHA)

Autor: PETER REAVEN, MICHELLE NEWELL, SALVADOR RIVAS, XINKAI ZHOU, GREGORY J. NORMAN, JIN ZHOU

Publikováno v: Diabetes. 71

Use of CGM in T2D is rising rapidly, yet little is known regarding its effects on glucose management in the VHA. We thus identified new CGM users (new CGM sensor prescriptions for T2D on insulin) and non-users (T2D receiving glucose strips) during th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::784becd0347545c74427dceecffb02e3
https://doi.org/10.2337/db22-1138-p

Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes

Autor: Sai Zhang, Pamela J. Shaw, A Dylan Fisher Barry, Michael Snyder, Thomas Julian, Johnathan Cooper-Knock, Tobias Moll, Calum Harvey, Yann C. Klimentidis, Nicholas Glascow, Michelle Newell

Publikováno v: EBioMedicine
EBioMedicine, Vol 68, Iss, Pp 103397-(2021)

BackgroundAmyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease. ALS is determined by gene-environment interactions and improved understanding of these interactions may lead to effective personalised medicine. The role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4985f038d9c31c7ea1774e201250e9
https://pubmed.ncbi.nlm.nih.gov/34157488

Type-2 diabetes with low LDL-C: genetic insights into a unique phenotype

Autor: Jose M. Ordovas, Michelle Newell, Jin Zhou, Amit Arora, Alexis C. Wood, Benjamin J. Renquist, Yann C. Klimentidis

Although hyperlipidemia is traditionally considered a risk factor for type-2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL-C increases T2D risk. We thus sought to comprehensively e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5210b30302dd8cc65b1bfa24b6ccd7