Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Michelle N Messmer"'
Autor:
Amy W Ku, Jason B Muhitch, Colin A Powers, Michael Diehl, Minhyung Kim, Daniel T Fisher, Anand P Sharda, Virginia K Clements, Kieran O'Loughlin, Hans Minderman, Michelle N Messmer, Jing Ma, Joseph J Skitzki, Douglas A Steeber, Bruce Walcheck, Suzanne Ostrand-Rosenberg, Scott I Abrams, Sharon S Evans
Publikováno v:
eLife, Vol 5 (2016)
Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that MDSC-mediated immunosuppression is restricted to tissues where MDSC co-min
Externí odkaz:
https://doaj.org/article/3703c01018fe4546bf5280e8e6082a72
Autor:
Lauren B. Kinner-Bibeau, Abigail L. Sedlacek, Michelle N. Messmer, Simon C. Watkins, Robert J. Binder
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasm
Externí odkaz:
https://doaj.org/article/cf78ebbf481d47ad9ecf5de60d0357a8
Autor:
Elizabeth A. Repasky, Bonnie L. Hylander, Scott I. Abrams, Kristopher Attwood, Michelle N. Messmer, Jason W.-L. Eng, Kathleen M. Kokolus, Haichao Liu, Brian Niedzwecki, Lauren Evans, Thejaswini Giridharan, Cameron R. MacDonald, Guanxi Qiao, Mark J. Bucsek
This data shows that housing mice at 30 degrees Celsius improves the efficacy of anti-PD-1 in both 4T1 and B16-OVA tumor-bearing mice indicating that cool housing temperatures (22 degrees C) impairs the efficacy of anti-PD-1 in murine tumor models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600baffff9aca5eeba91cd8561516aec
https://doi.org/10.1158/0008-5472.22414770
https://doi.org/10.1158/0008-5472.22414770
Autor:
Elizabeth A. Repasky, Bonnie L. Hylander, Scott I. Abrams, Kristopher Attwood, Michelle N. Messmer, Jason W.-L. Eng, Kathleen M. Kokolus, Haichao Liu, Brian Niedzwecki, Lauren Evans, Thejaswini Giridharan, Cameron R. MacDonald, Guanxi Qiao, Mark J. Bucsek
The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We report here that CD8+ T-cell frequency and functional orientation within the tumor microenviron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec282661638d66a258465c3d3cac9c3
https://doi.org/10.1158/0008-5472.c.6509076.v1
https://doi.org/10.1158/0008-5472.c.6509076.v1
Publikováno v:
Autoimmune Diseases, Vol 2012 (2012)
Heat shock proteins (HSPs) have been known for decades for their ability to protect cells under stressful conditions. In the 1980s a new role was ascribed for several HSPs given their ability to elicit specific immune responses in the setting of canc
Externí odkaz:
https://doaj.org/article/f170cfafc3fd44ce8ad8c0e0fc51676b
Autor:
Cameron R. MacDonald, Scott I. Abrams, Thejaswini Giridharan, Bonnie L. Hylander, Mark J. Bucsek, Jason W.-L. Eng, Haichao Liu, Guanxi Qiao, Kathleen M. Kokolus, Michelle N. Messmer, Kristopher Attwood, Brian Niedzwecki, Lauren Evans, Elizabeth A. Repasky
Publikováno v:
Cancer Research. 77:5639-5651
The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We report here that CD8+ T-cell frequency and functional orientation within the tumor microenviron
Autor:
Haiyin Chen-Harris, Pooja Ralli-Jain, Sharon Frase, Douglas R. Green, Annelise G. Snyder, Susana Orozco, Stephen W.G. Tait, Brian P. Daniels, Andrew Oberst, Nader Yatim, Sean P. Cullen, Giovanni Quarato, Michelle N. Messmer, Matthew L. Albert
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2275-2287.e5 (2019)
Summary: Necroptosis is a form of programmed cell death that is defined by activation of the kinase RIPK3 and subsequent cell membrane permeabilization by the effector MLKL. RIPK3 activation can also promote immune responses via production of cytokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4126e436d4541a1a236b317aa7932e3
https://europepmc.org/articles/PMC6857709/
https://europepmc.org/articles/PMC6857709/
Autor:
Susana Orozco, Cassidy E. Hagan, Michelle N. Messmer, Sigal B. Kofman, Annelise G. Snyder, Andrew Oberst, David Baker, Brian P. Daniels, Kristy Chiang, Nicholas Hubbard
Although the signaling events that induce different forms of programmed cell death (PCD) are well-defined, the downstream immune responses to dying cells in the context of cancer remain relatively unexplored. Necroptosis occurs downstream of the rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef46ca1393c0bbc8c8d9324fb151d36b
https://europepmc.org/articles/PMC6831211/
https://europepmc.org/articles/PMC6831211/
Our conception of programmed cell death has expanded beyond apoptosis to encompass additional forms of cell suicide, including necroptosis and pyroptosis; these cell death modalities are notable for their diverse and emerging roles in engaging the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567e2e5f847d2d0301426dd09d44ee9b
https://europepmc.org/articles/PMC6294769/
https://europepmc.org/articles/PMC6294769/
Publikováno v:
Oxford Medicine
The immune system serves as an integral checkpoint to developing malignancies. However, when cancer ultimately becomes detectable, this implicates an inherent failure of effective immune control. One constant theme in cancer biology has been the abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::875729aaacd456bea0875748ac06e170
https://doi.org/10.1093/med/9780190248208.003.0012
https://doi.org/10.1093/med/9780190248208.003.0012