Effect of intermittent glutamine supplementation on skeletal muscle is not long-lasting in very old rats

Autor: Anne-Marie Beaufrère, Dominique Meynial-Denis, Michelle Mignon, P. Patureau Mirand

Publikováno v: Journal of Nutrition, Health and Aging
Journal of Nutrition, Health and Aging, Springer Verlag (Germany), 2013, 17 (10), pp.876-879. ⟨10.1007/s12603-013-0353-8⟩
Journal of Nutrition, Health & Aging
Journal of Nutrition, Health & Aging, Springer Verlag (Germany), 2013, 17 (10), pp.876-879. ⟨10.1007/s12603-013-0353-8⟩

Background and objective: Muscle is the major site for glutamine synthesis via glutamine synthetase (GS). This enzyme is increased 1.5-2 fold in 25-27-mo rats and may be a consequence of aging-induced stress. This stimulation is similar to the induct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadfb1d4884a605c0fc1388cb928093f
https://doi.org/10.1007/s12603-013-0353-8

Contribution of proteolysis and de novo synthesis to alanine production in diabetic rat skeletal muscle: a 15 N/ 1 H nuclear magnetic resonance study

Autor: Loïc Foucat, Jean-Pierre Renou, J. Prugnaud, A. Chavaroux, Michelle Mignon, Maurice Arnal, G. Bayle, Dominique Meynial-Denis

Publikováno v: Diabetologia
Diabetologia, Springer Verlag, 1997, 40, pp.1159-1165. ⟨10.1007/s001250050801⟩

To assess the role of leucine as a precursor of alanine α-amino nitrogen in skeletal muscle during diabetes, extensor digitorum longus muscles from control (n = 7 experiments) and streptozotocin-diabetic rats (n = 8 experiments) were isolated and su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77f35b1f33fffb94d48807943bffc28
https://doi.org/10.1007/s001250050801

Fasting up-regulates muscle glutamine synthetase while it down-regulates liver glutamine synthetase in male rats during aging

Autor: Sébastien Bes, Marie-Laure Mouchard, Dominique Meynial-Denis, Michelle Mignon

Publikováno v: e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism
e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, Elsevier, 2008, 3 (6), pp.e309-e315. ⟨10.1016/j.eclnm.2008.07.019⟩

International audience; Background & aims: Muscle is an important site of Gln synthesis and release in the whole body, while liver can take up circulating Gln even if it has the capacity to both degrade and synthesize Gln. During fasting, skeletal mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110a8d8a6cea013c8ea0caa5748fddf1
https://hal.inrae.fr/hal-02653778

Does glutamine supplementation decrease the response of muscle glutamine synthesis to fasting in muscle in adult and very old rats ?

Autor: Dominique Meynial-Denis, Emilie Bonnel, Loïc Lêvêque, Michelle Mignon

Publikováno v: Journal of Parenteral and Enteral Nutrition
Journal of Parenteral and Enteral Nutrition, SAGE Publications (UK and US), 2007, 31 (1), pp.26-31. ⟨10.1177/014860710703100126⟩

International audience; BACKGROUND: Glutamine synthetase (GS), a key enzyme in the production of glutamine, is preserved in rat skeletal muscle during aging but is increased with advanced age in vivo. The aim of this study was to determine whether gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85340fcde4dc9b40672a06f01b1f77e
https://hal.inrae.fr/hal-02658504

Insulin-dependent glycogen synthesis is delayed in onset in the skeletal muscle of food-deprived aged rats

Autor: Guy Bielicki, Ahmed Miri, Jean Grizard, Dominique Meynial-Denis, Michelle Mignon, Jean-Pierre Renou

Publikováno v: Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry, Elsevier, 2005, 16 (3), pp.150-154. ⟨10.1016/j.jnutbio.2004.12.001⟩

International audience; Insulin resistance with aging may be responsible for impaired glycogen synthesis in the skeletal muscle of aged rats and contribute to the well-known decreased ability to respond to stress with aging. For this reason, to asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e206b9447fa2660e215d9fcc2f4159dc
https://hal.inrae.fr/hal-02681814