Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Michelle McMullen"'
Publikováno v:
Gynecologic Oncology Reports, Vol 48, Iss , Pp 101246- (2023)
Objective: Poly-ADP ribose polymerase inhibitors (PARPi) have expanded the management armamentarium against high grade serous tubo-ovarian cancer (HGSOC) in patients with germline and somatic BRCA pathogenic variants (PVs). Germline testing has been
Externí odkaz:
https://doaj.org/article/8f6eb6782f0649419682840bd668424f
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101249- (2022)
Externí odkaz:
https://doaj.org/article/5e30c2bae62c465fb5f37f108eb3939c
Autor:
Amit M Oza, Qin Liu, Ainhoa Madariaga, Lawrence Kasherman, Lisa Wang, Michelle McMullen, Katherine Karakasis, Luisa Bonilla, Shiru (Lucy) Liu, Rouhi Fazelzad, Ann M Heesters
Publikováno v:
BMJ Open, Vol 11, Iss 7 (2021)
Objectives In response to the COVID-19 pandemic there have been significant developments in research, its conduct and the supporting ethical framework. While many protocols have been delayed, halted or modified, other research efforts have been accel
Externí odkaz:
https://doaj.org/article/e3c91c157690489db6792a5db944016d
Publikováno v:
Seminars in Cancer Biology. 77:167-181
Platinum is the backbone of systemic treatment in ovarian cancer and development of platinum resistance is associated with poor survival. Here, we perform a comprehensive review of the literature regarding resistance mechanisms and advances in therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b302e586f8348555291d51cafe777985
https://doi.org/10.1016/j.semcancer.2020.08.013
https://doi.org/10.1016/j.semcancer.2020.08.013
Autor:
Angela Ives, Patsy Yates, Madeleine King, Tarek Meniawy, Sue Hegarty, Phyllis Butow, Orla McNally, Rachel Campbell, Andrew Dean, Anne Mellon, Wanda Lawson, Linda Mileshkin, Isobel Black, Michelle McMullen, Sanela Bilic, Cyril Dixon, Jane Hill, Rachael L. Morton, Jeffrey C. Goh, Val Gebski, Michael Friedlander, Penelope M. Webb, Yeh Chen Lee, Stephanie Jeffares, Rhonda Beach, Paul A. Cohen, Philip Beale, Alison Brand, Jim Codde, Andreas Obermair
Publikováno v:
International Journal of Gynecologic Cancer. 32:560-565
BackgroundPhysical symptoms, anxiety, depression, fear of recurrence, sexual dysfunction, and social withdrawal are common in women after treatment for ovarian cancer. Most patients would like and need help dealing with these symptoms. The traditiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5109d2a1a187d96e4669c49b26bf2d72
https://doi.org/10.1136/ijgc-2021-002999
https://doi.org/10.1136/ijgc-2021-002999
Publikováno v:
International Journal of Gynecological Cancer
BackgroundWith the success of poly(ADP-ribose) polymerase (PARP) inhibitor therapy in the first-line and second-line treatment settings, a new patient population is emerging with platinum-sensitive relapsed ovarian cancer, who have previously receive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8092ed10fd5b94a2613e848955d3c54f
https://doi.org/10.1136/ijgc-2020-001694
https://doi.org/10.1136/ijgc-2020-001694
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101249-(2022)
Translational Oncology
Translational Oncology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b0dc30d189907cdd814a0cb075a41e
http://www.sciencedirect.com/science/article/pii/S1936523321002412
http://www.sciencedirect.com/science/article/pii/S1936523321002412
Publikováno v:
Nature Cancer. 2:6-8
Recent preclinical and clinical research has led to exciting advances related to high-grade serous ovarian cancer, from examining its cellular origins to gaining insight into DNA-damage-repair mechanisms that may be leveraged for therapies. Furthermo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30d28efccb23853afe031421bd003a8
https://doi.org/10.1038/s43018-020-00166-5
https://doi.org/10.1038/s43018-020-00166-5
Autor:
Ainhoa Madariaga, Amit M. Oza, Michelle McMullen, Rouhi Fazelzad, Lawrence Kasherman, Luisa Bonilla, Qin Liu, Katherine Karakasis, Ann Heesters, Shiru Lucy Liu, Lisa Wang
Publikováno v:
BMJ Open, Vol 11, Iss 7 (2021)
BMJ Open
BMJ Open
ObjectivesIn response to the COVID-19 pandemic there have been significant developments in research, its conduct and the supporting ethical framework. While many protocols have been delayed, halted or modified, other research efforts have been accele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993247e8bafefd2c02ab6427213062ab
https://bmjopen.bmj.com/content/11/7/e047076.full
https://bmjopen.bmj.com/content/11/7/e047076.full
Autor:
Husam Alqaisi, Stephanie Lheureux, Michelle McMullen, Jennifer J. Knox, Valerie Bowering, Crystal Lee, Rishi Chinta, Leslie Aguilar, Daniel McCormick, Ariel Chang, Chi-En Huang, Kasia Koziol, John Soong, Diane M. Provencher, Lee S. Rosen, Amit M. Oza
Publikováno v:
Journal of Clinical Oncology. 40:TPS5621-TPS5621
TPS5621 Background: Pre-clinical and clinical data demonstrate that CX-5461 selectively kills HR deficient cancer cells through stabilizing G4 structures and inducing replication-dependent DNA damage. Phase 1 studies suggest CX-5461 has clinical acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5583cf4dcd8473639bcbfd190e3e65c
https://doi.org/10.1200/jco.2022.40.16_suppl.tps5621
https://doi.org/10.1200/jco.2022.40.16_suppl.tps5621