Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Michelle M. Sopko"'
Autor:
Michelle M. Sopko, Brian C. Raimundo, Joni W. Lam, Thomas O'Brien, Bruce T. Fahr, Michael J. Romanowski, Nathan D. Waal, Hans E. Purkey, Phuongly Pham
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 61:451-458
Caspase-1 is a key endopeptidase responsible for the post-translational processing of the IL-1beta and IL-18 cytokines and small-molecule inhibitors that modulate the activity of this enzyme are predicted to be important therapeutic treatments for ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ad06d584582bb7f3a2800e192a531f
https://doi.org/10.1107/s1744309105010109
https://doi.org/10.1107/s1744309105010109
Autor:
Shannon O. Harris, Stacey A. Heumann, Jeffrey W. Jacobs, William Michael Flanagan, Subramanian Baskaran, Kristin M. Zimmerman, Darin Allen, Minna Bui, Michael J. Romanowski, Bradley T. Tangonan, Johan D. Oslob, Robert S. McDowell, Wang Shen, Chris E Lawrence, Juli N. Teague, Willard Lew, Michelle M. Sopko, Michelle A. Nannini, Jeffrey A. Silverman, Joshua C. Yoburn, Chul Yu, Min Zhong, Hanan Emily, Ute Hoch, Amy D. Fung, Joni Lam, Robert A. Elling, Thomas O'Brien
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(17)
This communication describes the discovery of a novel series of Aurora kinase inhibitors. Key SAR and critical binding elements are discussed. Some of the more advanced analogues potently inhibit cellular proliferation and induce phenotypes consisten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6628e44d37788613c268d76ba8583b8
https://pubmed.ncbi.nlm.nih.gov/18678489
https://pubmed.ncbi.nlm.nih.gov/18678489
Autor:
Sam John, Bhavin S. Parekh, William G. Mallet, Michelle M. Sopko, Nam V. Nguyen, Thomas D. Schaal, Dustin L. McMinn
Publikováno v:
Nucleic acids research. 31(4)
Polyamides are a class of heterocyclic small molecules with the potential of controlling gene expression by binding to the minor groove of DNA in a sequence-specific manner. To evaluate the feasibility of this class of compounds as antiviral therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880017bb611683f533e246eff2b2db5c
https://pubmed.ncbi.nlm.nih.gov/12582248
https://pubmed.ncbi.nlm.nih.gov/12582248