Výsledky vyhledávání - "Michelle M. Sandau"

IL-15 Regulates Both Quantitative and Qualitative Features of the Memory CD8 T Cell Pool

Autor: David L. Woodland, Jacob E. Kohlmeier, Michelle M. Sandau, Stephen C. Jameson

Publikováno v: The Journal of Immunology. 184:35-44

Memory T cells are critical for immunity to various intracellular pathogens. Recent studies have indicated that CD8 secondary memory cells, induced by prime-boost approaches, show enhanced protective function compared with primary memory cells and ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eafc69ed5920da8d22d6879fb6798235
https://doi.org/10.4049/jimmunol.0803355

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Innate Immune Activation of CD4 T Cells in Salmonella-Infected Mice Is Dependent on IL-18

Autor: Leo Lefrançois, Rosa Maria Salazar-Gonzalez, Michael Jarcho, Stephen J. McSorley, Michelle M. Sandau, Aparna Srinivasan

Publikováno v: The Journal of Immunology. 178:6342-6349

Production of IFN-γ by CD4 T cells is generally thought to be mediated by TCR triggering, however, Ag-nonspecific activation of effector CD8 T cells has been reported in infection models. In this study, we demonstrate that Ag-experienced CD4 T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25efac40b33842eaff9ab4195f817e3
https://doi.org/10.4049/jimmunol.178.10.6342

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Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression

Autor: Michelle M. Sandau, Mona Mashayekhi, Kenneth M. Murphy, Jörn C. Albring, Aaron S. Rapaport, Theresa L. Murphy, Brian T. Edelson, Ansuman T. Satpathy, Matthias Stelljes, Marco Colonna, Stephanie K. Lathrop, Chyi-Song Hsieh

Publikováno v: The Journal of Experimental Medicine

One-time treatment with an antibody against BTLA provides long-term protection against graft-versus-host disease without affecting effector T cell responses to tumors or pathogens.
Graft-versus-host disease (GVHD) causes significant morbidity an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970fea77370f6109a783e68aa56e4222
https://pubmed.ncbi.nlm.nih.gov/21078889

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Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation

Autor: Kenneth M. Murphy, John J. Schwarz, Osamu Nakagawa, Jörn C. Albring, Michelle M. Sandau, Peter R. Wilker, Masako Kohyama

Publikováno v: Nature immunology. 9(6)

Calcineurin is required for B cell receptor (BCR)-induced proliferation of mature B cells. Paradoxically, loss of NFAT transcription factors, themselves calcineurin targets, induces hyperactivity, which suggests that calcineurin targets other than NF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e722e87d9789ac6d9a26bdf4201e4f
https://pubmed.ncbi.nlm.nih.gov/18438409

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The sialyltransferase ST3Gal-I is not required for regulation of CD8-class I MHC binding during T cell development

Autor: Michelle M. Sandau, Mark A. Daniels, Stephen C. Jameson, Charlly Kao

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 176(12)

The CD8 coreceptor plays a crucial role in thymocyte and T cell sensitivity by binding to class I MHC and recruiting downstream signaling molecules to the TCR. Previous studies reported considerable changes in TCR-independent CD8/class I MHC binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d888f969772e7a8d7c9fa8858c744703
https://pubmed.ncbi.nlm.nih.gov/16751387

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The timing of TCR alpha expression critically influences T cell development and selection

Autor: Kristin A. Hogquist, Michelle M. Sandau, Troy A. Baldwin, Stephen C. Jameson

Publikováno v: The Journal of Experimental Medicine

Sequential rearrangement of the T cell receptor for antigen (TCR) beta and alpha chains is a hallmark of thymocyte development. This temporal control is lost in TCR transgenics because the alpha chain is expressed prematurely at the CD4- CD8- double

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9891eae1ea840aec93dd08c5e0b5ab1c
https://pubmed.ncbi.nlm.nih.gov/15998791

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Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells

Autor: Stephen C. Jameson, Leo Lefrançois, Kimberly S. Schluns, Michelle M. Sandau

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 173(11)

IL-15 is critical for generation of multiple lymphoid subsets. Recent data have demonstrated a unique aspect of responses to IL-15, in that cells bearing the IL-15Rα chain can bind soluble IL-15 and “transpresent” the cytokine to other cells, al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7976c491083aa02830eb73ff032f1c1
https://pubmed.ncbi.nlm.nih.gov/15557143

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CD8α+ Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii Tachyzoites

Autor: Theresa L. Murphy, Hidde L. Ploegh, Kenneth M. Murphy, Alan Sher, Mona Mashayekhi, Michelle M. Sandau, Romina S. Goldszmid, L. David Sibley, Asis Khan, Eva M. Frickel, Ildiko Rita Dunay

Publikováno v: PMC

CD8α[superscript +] dendritic cells (DCs) are important in vivo for cross-presentation of antigens derived from intracellular pathogens and tumors. Additionally, secretion of interleukin-12 (IL-12) by CD8α[superscript +] DCs suggests a role for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770ad3eb1bb1afbe0c220555387b12ed

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IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells

Autor: Michelle M. Sandau, Colleen J. Winstead, Stephen C. Jameson

Publikováno v: ResearcherID

Naive T cells undergo slow homeostatic proliferation in response to T cell lymphopenia, which is also called lymphopenia-induced proliferation (LIP). IL-7 is critically required for this process, but previous studies suggested IL-15 was expendable fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51c8954180ec303be5437d7a169e4f0
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000247497600018&KeyUID=WOS:000247497600018

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