Correction: Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish.

Autor: Anna M Sokol, Barbara Uszczynska-Ratajczak, Michelle M Collins, Michal Bazala, Ulrike Topf, Pia R Lundegaard, Sreedevi Sugunan, Stefan Guenther, Carsten Kuenne, Johannes Graumann, Sherine S L Chan, Didier Y R Stainier, Agnieszka Chacinska

Publikováno v: PLoS Genetics, Vol 15, Iss 1, p e1007972 (2019)

[This corrects the article DOI: 10.1371/journal.pgen.1007743.].

Externí odkaz: https://doaj.org/article/7b73b7d754a74cebb5b5c4b59e3956f3

Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration

Autor: Michelle M Collins, Hans-Martin Maischein, Pascale Dufourcq, Marine Charpentier, Patrick Blader, Didier YR Stainier

Publikováno v: eLife, Vol 7 (2018)

Pitx2c, a homeodomain transcription factor, is classically known for its left-right patterning role. However, an early wave of pitx2 expression occurs at the onset of gastrulation in several species, indicating a possible earlier role that remains re

Externí odkaz: https://doaj.org/article/81769231a235401ebcf627e31dd2e6a3

Modeling Human Cardiac Arrhythmias: Insights from Zebrafish

Autor: Sébastien Gauvrit, Jaclyn Bossaer, Joyce Lee, Michelle M. Collins

Publikováno v: Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease, Vol 9, Iss 13, p 13 (2022)

Cardiac arrhythmia, or irregular heart rhythm, is associated with morbidity and mortality and is described as one of the most important future public health challenges. Therefore, developing new models of cardiac arrhythmia is critical for understand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9a770fb5dec17e0056aa11300e91f4
https://pubmed.ncbi.nlm.nih.gov/35050223

Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model

Autor: Stefan Guenther, Gustav Ahlberg, Rubén Marín-Juez, Hadil El-Sammak, Ylva Hellsten, Janett Piesker, Camilla Vestergaard Hansen, Pia R. Lundegaard, Anna M. Sokol, Didier Y.R. Stainier, Morten S. Olesen, Michelle M. Collins

Publikováno v: Proceedings of the National Academy of Sciences. 116:24115-24121

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. The major AF susceptibility locus 4q25 establishes long-range interactions with the promoter of PITX2 , a transcription factor gene with critical functions during cardiac develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19279ee4599d38ced4dd671eaaf5c329
https://doi.org/10.1073/pnas.1913905116

HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development

Autor: Stefan Guenther, Didier Y.R. Stainier, Clifford W. Bogue, Maurice A. Canham, Rubén Marín-Juez, Nana Fukuda, Philip Kitchen, Hans-Martin Maischein, Alethia Villasenor, Padma-Sheela Jayaraman, Sébastien Gauvrit, Michelle M. Collins, Boris Strilic, Joshua M. Brickman

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Gauvrit, S, Villasenor, A, Strilic, B, Kitchen, P, Collins, M M, Marin-Juez, R, Guenther, S, Maischein, H-M, Fukuda, N, Canham, M A, Brickman, J M, Bogue, C W, Jayaraman, P-S & Stainier, D Y R 2018, ' HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development. ', Nature Communications, vol. 9, no. 1, 2704 . https://doi.org/10.1038/s41467-018-05039-1
Nature Communications

Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet, how expression of these signaling compon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315e6d9554802919a21eebf08f58adb2
http://link.springer.com/article/10.1038/s41467-018-05039-1