Zobrazeno 1 - 10
of 699
pro vyhledávání: '"Michelle M, Mielke"'
Autor:
Dror Shir, Jonathan Graff-Radford, Angela J. Fought, Timothy G. Lesnick, Scott A. Przybelski, Maria Vassilaki, Val J. Lowe, David S. Knopman, Mary M. Machulda, Ronald C. Petersen, Clifford R. Jack, Jr, Michelle M. Mielke, Prashanthi Vemuri
Publikováno v:
NeuroImage: Clinical, Vol 43, Iss , Pp 103634- (2024)
Introduction: AD and CVD, which frequently co-occur, are leading causes of age-related cognitive decline. We assessed how demographic factors, socioeconomic status (SES) as indicated by education and occupation, vascular risk factors, and a range of
Externí odkaz:
https://doaj.org/article/feaeeef564a042beb90734dee33646ca
Autor:
Firat Kara, Christine M. Lohse, Anna M. Castillo, Nirubol Tosakulwong, Timothy G. Lesnick, Clifford R. Jack Jr, Ronald C. Petersen, Janet E. Olson, Fergus J. Couch, Kathryn J. Ruddy, Kejal Kantarci, Michelle M. Mielke
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 2805-2817 (2023)
Abstract The aim of this cross‐sectional study was to examine whether a history of selective estrogen receptor modifiers (SERMs), tamoxifen and raloxifene, use was associated with cognitive performance, odds of mild cognitive impairment (MCI), or m
Externí odkaz:
https://doaj.org/article/e8119463825d4cc49f66536f18e470cf
Autor:
Melissa E. Murray, Christina M. Moloney, Naomi Kouri, Jeremy A. Syrjanen, Billie J. Matchett, Darren M. Rothberg, Jessica F. Tranovich, Tiffany N. Hicks Sirmans, Heather J. Wiste, Baayla D. C. Boon, Aivi T. Nguyen, R. Ross Reichard, Dennis W. Dickson, Val J. Lowe, Jeffrey L. Dage, Ronald C. Petersen, Clifford R. Jack, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, Michelle M. Mielke
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-14 (2022)
Abstract Background Advances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer’s disease (AD) biomarker changes. Examination of postmortem brains of participants with antemor
Externí odkaz:
https://doaj.org/article/4d7fc8dcbfb540b2928a445f125243c0
Autor:
Daan vanKruining, Mario Losen, Simone M. Crivelli, Joost J. A. deJong, Jacobus F. A. Jansen, Walter H. Backes, Jennifer Monereo‐Sánchez, Martin P. J. vanBoxtel, Sebastian Köhler, David E. J. Linden, Miranda T. Schram, Michelle M. Mielke, Pilar Martinez‐Martinez
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 3, Pp n/a-n/a (2023)
Abstract Introduction There is an urgent need for biomarkers identifying individuals at risk of early‐stage cognitive impairment. Using cross‐sectional data from The Maastricht Study, this study included 197 individuals with mild cognitive impair
Externí odkaz:
https://doaj.org/article/a188817f504247eb896e38e9abae158a
Autor:
Nansu Zong, Andrew Wen, Sungrim Moon, Sunyang Fu, Liwei Wang, Yiqing Zhao, Yue Yu, Ming Huang, Yanshan Wang, Gang Zheng, Michelle M. Mielke, James R. Cerhan, Hongfang Liu
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-8 (2022)
Abstract Computational drug repurposing methods adapt Artificial intelligence (AI) algorithms for the discovery of new applications of approved or investigational drugs. Among the heterogeneous datasets, electronic health records (EHRs) datasets prov
Externí odkaz:
https://doaj.org/article/dd87bad5c07f4d129118fb56e76dd39f
Autor:
Sunghwan Sohn, Janet E Olson, Suzette J Bielinski, Jennifer L St Sauver, Michaela E McGree, Walter A Rocca, Michelle M Mielke, Nathan K LeBrasseur, Susan A Weston
Publikováno v:
BMJ Open, Vol 13, Iss 4 (2023)
Objective Ceramides have been associated with several ageing-related conditions but have not been studied as a general biomarker of multimorbidity (MM). Therefore, we determined whether ceramide levels are associated with the rapid development of MM.
Externí odkaz:
https://doaj.org/article/ee7865fc0f2a4a24aa12b272c2a1762f
Autor:
Sheelakumari Raghavan, Scott A. Przybelski, Robert I. Reid, Timothy G. Lesnick, Vijay K. Ramanan, Hugo Botha, Billie J. Matchett, Melissa E. Murray, R. Ross Reichard, David S. Knopman, Jonathan Graff-Radford, David T. Jones, Val J. Lowe, Michelle M. Mielke, Mary M. Machulda, Ronald C. Petersen, Kejal Kantarci, Jennifer L. Whitwell, Keith A. Josephs, Clifford R. Jack, Prashanthi Vemuri
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Multi-compartment modelling of white matter microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI) can provide information on white matter health through neurite density index and free water measures. We hypothesized
Externí odkaz:
https://doaj.org/article/688e5b6e71234dd09762d60ffedd3aa6
Autor:
Jordan D. Marks, Jeremy A. Syrjanen, Jonathan Graff-Radford, Ronald C. Petersen, Mary M. Machulda, Michelle R. Campbell, Alicia Algeciras-Schimnich, Val Lowe, David S. Knopman, Clifford R. Jack, Prashanthi Vemuri, Michelle M. Mielke, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Total tau protein (T-Tau) and neurofilament light chain (NfL) have emerged as candidate plasma biomarkers of neurodegeneration, but studies have not compared how these biomarkers cross-sectionally or longitudinally associate with
Externí odkaz:
https://doaj.org/article/1c79f5778aa341c8afd4c26414d61b71
Autor:
Diego Z. Carvalho, Erik K. St. Louis, Scott A. Przybelski, Timothy I. Morgenthaler, Mary M. Machulda, Bradley F. Boeve, Ronald C. Petersen, Clifford R. Jack, Jonathan Graff-Radford, Prashanthi Vemuri, Michelle M. Mielke
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
IntroductionSleepiness has been associated with cognitive decline and dementia in the elderly. Older adults with excessive daytime sleepiness appear to be more vulnerable to longitudinal amyloid PET accumulation before the onset of the dementia. Howe
Externí odkaz:
https://doaj.org/article/8df66f5645474bc3a7c4061114b8c746
Autor:
Vijay K. Ramanan, Timothy G. Lesnick, Scott A. Przybelski, Michael G. Heckman, David S. Knopman, Jonathan Graff-Radford, Val J. Lowe, Mary M. Machulda, Michelle M. Mielke, Clifford R. Jack, Ronald C. Petersen, Owen A. Ross, Prashanthi Vemuri, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Although abnormal accumulation of amyloid in the brain is an early biomarker of Alzheimer’s disease (AD), wide variation in cognitive trajectories during life can be seen in the setting of brain amyloidosis, ranging from maintenance of nor
Externí odkaz:
https://doaj.org/article/140d06ba4b7b4132a97aee491a21bdf9