The draft nuclear genome sequence and predicted mitochondrial proteome of Andalucia godoyi, a protist with the most gene-rich and bacteria-like mitochondrial genome

Autor: Michael W. Gray, Gertraud Burger, Romain Derelle, Vladimír Klimeš, Michelle M. Leger, Matt Sarrasin, Čestmír Vlček, Andrew J. Roger, Marek Eliáš, B. Franz Lang

Publikováno v: BMC Biology, Vol 18, Iss 1, Pp 1-35 (2020)

Abstract Background Comparative analyses have indicated that the mitochondrion of the last eukaryotic common ancestor likely possessed all the key core structures and functions that are widely conserved throughout the domain Eucarya. To date, such st

Externí odkaz: https://doaj.org/article/17a948f9a5bb494d83671541d01f6b73

Eukaryotic evolution: Spatial proteomics sheds light on mitochondrial reduction

Autor: Michelle M, Leger, Courtney, Stairs

Publikováno v: Current Biology. 32:R1308-R1311

Multi-organelle spatial proteomics has revolutionized animal cell biology, but its use in protists has so far been limited. A new study delivers the first such proteome of a free-living protist, uncovering a previously overlooked function of highly r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef14108dd45c07e7e9bdafff4b827776
https://doi.org/10.1016/j.cub.2022.10.039

Intracytoplasmic-membrane development in alphaproteobacteria involves the homolog of the mitochondrial crista-developing protein Mic60

Autor: Sergio A. Muñoz-Gómez, Lawrence Rudy Cadena, Alastair T. Gardiner, Michelle M. Leger, Shaghayegh Sheikh, Louise B. Connell, Tomáš Bilý, Karel Kopejtka, J. Thomas Beatty, Michal Koblížek, Andrew J. Roger, Claudio H. Slamovits, Julius Lukeš, Hassan Hashimi

Publikováno v: Current Biology. 33:1396

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8edc5df6bb3d3afd2ffb6b0b9b2ea94
https://doi.org/10.1016/j.cub.2023.03.049

The development of intracytoplasmic membranes in alphaproteobacteria involves the conserved mitochondrial crista-developing protein Mic60

Autor: Sergio A. Muñoz-Gómez, Lawrence Rudy Cadena, Alastair T. Gardiner, Michelle M. Leger, Shaghayegh Sheikh, Louise Connell, Tomáš Bilý, Karel Kopejtka, J. Thomas Beatty, Michal Koblížek, Andrew J. Roger, Claudio H. Slamovits, Julius Lukeš, Hassan Hashimi

Mitochondrial cristae expand the surface area of respiratory membranes and ultimately allow for the evolutionary scaling of respiration with cell volume across eukaryotes. The discovery of Mic60 homologs among alphaproteobacteria, the closest extant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c77d0026f70c18c1da36a6142523b31
https://doi.org/10.1101/2022.06.14.496148

Evolution of a histone variant involved in compartmental regulation of NAD metabolism

Autor: Iva Guberovic, Sarah Hurtado-Bagès, Ciro Rivera-Casas, Gunnar Knobloch, Roberto Malinverni, Vanesa Valero, Michelle M. Leger, Jesús García, Jerome Basquin, Marta Gómez de Cedrón, Marta Frigolé-Vivas, Manjinder S. Cheema, Ainhoa Pérez, Juan Ausió, Ana Ramírez de Molina, Xavier Salvatella, Iñaki Ruiz-Trillo, Jose M. Eirin-Lopez, Andreas G. Ladurner, Marcus Buschbeck

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de la UB
Universidad de Barcelona
NATURE STRUCTURAL & MOLECULAR BIOLOGY
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Nature Structural and Molecular Biology

NAD metabolism is essential for all forms of life. Compartmental regulation of NAD consumption, especially between the nucleus and the mitochondria, is required for energy homeostasis. However, how compartmental regulation evolved remains unclear. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afa5b464fefff113bd6e2ff9ef2e479
http://hdl.handle.net/10261/263537