Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Michelle Lira"'
Autor:
Frank Stegmeier, Michael R. Schlabach, Junxia Min, Yi Yang, HoMan Chan, Veronica Gibaja, Michelle Lira, Iris Kao, Daniel Rakiec, David Ruddy, Adnan Derti, Qianhe Zhou
Supplemental Table 3: List of alternatively spliced genes identified in response to SF3B1 mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a18bb0f8d4724ecc90c7877a1b662da
https://doi.org/10.1158/0008-5472.22405301.v1
https://doi.org/10.1158/0008-5472.22405301.v1
Autor:
Frank Stegmeier, Michael R. Schlabach, Junxia Min, Yi Yang, HoMan Chan, Veronica Gibaja, Michelle Lira, Iris Kao, Daniel Rakiec, David Ruddy, Adnan Derti, Qianhe Zhou
Assessing the functional significance of novel putative oncogenes remains a significant challenge given the limitations of current loss-of-function tools. Here, we describe a method that employs TALEN or CRISPR/Cas9-mediated knock-in of inducible deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458b45e418d201e1017b53be47f0dfae
https://doi.org/10.1158/0008-5472.c.6506798
https://doi.org/10.1158/0008-5472.c.6506798
Autor:
Frank Stegmeier, Michael R. Schlabach, Junxia Min, Yi Yang, HoMan Chan, Veronica Gibaja, Michelle Lira, Iris Kao, Daniel Rakiec, David Ruddy, Adnan Derti, Qianhe Zhou
Supplemental Figure 1. Efficient knock�in of DD�domain into the endogenous p53 locus by TALENs in HCT116 cells. Supplemental Figure 2. PCR verification of Degron�KI clones. Supplemental Figure 3. Immunofluorescence staining of De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b300a710390d54707412a6f01d0556b
https://doi.org/10.1158/0008-5472.22405304.v1
https://doi.org/10.1158/0008-5472.22405304.v1
Autor:
Daniel P. Rakiec, David A. Ruddy, Veronica Gibaja, Iris Kao, Ho Man Chan, Michael R. Schlabach, Frank Stegmeier, Adnan Derti, Junxia Min, Yi Yang, Michelle Lira, Qianhe Zhou
Publikováno v:
Cancer Research. 75:1949-1958
Assessing the functional significance of novel putative oncogenes remains a significant challenge given the limitations of current loss-of-function tools. Here, we describe a method that employs TALEN or CRISPR/Cas9-mediated knock-in of inducible deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cdd0df22074dc385e91796fec50af0
https://doi.org/10.1158/0008-5472.can-14-2930
https://doi.org/10.1158/0008-5472.can-14-2930
Autor:
Wei Qi, C G Paris, David A. Ruddy, Michelle Lira, J Harari, Daniel King, Tomas Rejtar, Huili Zhai, V Saenz-Vash, Zhengtian Yu, Nicholas Keen, A Q Hassan, Fang Shen, Veronica Gibaja, Joshua M. Korn, Ho Man Chan
Publikováno v:
Oncogene
The histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2) is frequently dysregulated in cancers, and gain-of-function (GOF) EZH2 mutations have been identified in non-Hodgkin lymphomas. Small-molecule inhibitors against EZH2 demonstrated anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8996d2e21185249704b423c3a6253716
http://europepmc.org/articles/PMC4744243
http://europepmc.org/articles/PMC4744243
Publikováno v:
Cancer Research. 74:5142-5142
Proteins that regulate chromatin dynamics and post-translational modifications of histones are crucial transcriptional regulators, and are implicated in diverse cellular processes including proliferation, differentiation and genome integrity control.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::138327ef70efb01ef822bf503bab6c51
https://doi.org/10.1158/1538-7445.am2014-5142
https://doi.org/10.1158/1538-7445.am2014-5142