Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Michelle Lifton"'
Autor:
Catherine Jacob-Dolan, Michelle Lifton, Olivia C. Powers, Jessica Miller, Nicole P. Hachmann, Mya Vu, Nehalee Surve, Camille R. Mazurek, Jana L. Fisher, Stefanie Rodrigues, Robert C. Patio, Trisha Anand, Mathieu Le Gars, Jerald Sadoff, Aaron G. Schmidt, Dan H. Barouch
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109716- (2024)
Summary: The viral vector-based COVID-19 vaccine Ad26.COV2.S has been recommended by the WHO since 2021 and has been administered to over 200 million people. Prior studies have shown that Ad26.COV2.S induces durable neutralizing antibodies (NAbs) tha
Externí odkaz:
https://doaj.org/article/319b65fba338482abc0eb9e090cc8de1
Autor:
Daniel Y Zhu, Matthew J Gorman, Dansu Yuan, Jingyou Yu, Noe B Mercado, Katherine McMahan, Erica N Borducchi, Michelle Lifton, Jinyan Liu, Felix Nampanya, Shivani Patel, Lauren Peter, Lisa H Tostanoski, Laurent Pessaint, Alex Van Ry, Brad Finneyfrock, Jason Velasco, Elyse Teow, Renita Brown, Anthony Cook, Hanne Andersen, Mark G Lewis, Douglas A Lauffenburger, Dan H Barouch, Galit Alter
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001609 (2022)
Despite the rapid creation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccines, the precise correlates of immunity against severe Coronavirus Disease 2019 (COVID-19) are still unknown. Neutralizing antibodies represent a robust s
Externí odkaz:
https://doaj.org/article/4d1be3554a1648f7a95b8e4694bcb0af
Autor:
Griffin Woolley, Matthew Mosher, Kyle Kroll, Rhianna Jones, Brady Hueber, Sho Sugawara, Cordelia Manickam, Karen Terry, Valerie Varner, Michelle Lifton, Daniel Ram, Christine M. Fennessey, Brandon F. Keele, R. Keith Reeves
Publikováno v:
J Virol
Natural killer (NK) cells are potent effector cells of the innate immune system possessing both cytotoxic and immunoregulatory capabilities, which contribute to their crucial role in controlling human immunodeficiency virus (HIV) and simian immunodef
Autor:
Jinyan Liu, Abishek Chandrashekar, Daniel Sellers, Julia Barrett, Catherine Jacob-Dolan, Michelle Lifton, Katherine McMahan, Michaela Sciacca, Haley VanWyk, Cindy Wu, Jingyou Yu, Ai-ris Y. Collier, Dan H. Barouch
Publikováno v:
Nature. 603:493-496
The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike protein1. Cellular immune responses, particularly
Autor:
Jingyou Yu, Paul V. Thomas, Katherine McMahan, Catherine Jacob-Dolan, Jinyan Liu, Xuan He, David Hope, Elizabeth J. Martinez, Wei-Hung Chen, Michaela Sciacca, Nicole P. Hachmann, Michelle Lifton, Jessica Miller, Olivia C. Powers, Kevin Hall, Cindy Wu, Julia Barrett, Isabella Swafford, Jeffrey R. Currier, Jocelyn King, Courtney Corbitt, William C. Chang, Emily Golub, Phyllis A. Rees, Caroline E. Peterson, Agnes Hajduczki, Elizabeth Hussin, Camille Lange, Hua Gong, Gary R. Matyas, Mangala Rao, Dominic Paquin-Proulx, Gregory D. Gromowski, Mark G. Lewis, Hanne Andersen, Meredith Davis-Gardner, Mehul S. Suthar, Nelson L. Michael, Diane L. Bolton, M. Gordon Joyce, Kayvon Modjarrad, Dan H. Barouch
Publikováno v:
Science Advances. 8
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and waning immunity call for next-generation vaccine strategies. Here, we assessed the immunogenicity and protective efficacy of two SARS-CoV-2 vaccines targeting the WA1/
Autor:
Xuan He, Malika Aid, John D. Ventura, Erica Borducchi, Michelle Lifton, Jinyan Liu, Dan H. Barouch
Publikováno v:
Journal of Virology. 96
The mechanisms underlying depletion of CD4 T cells during acute HIV-1 infection are not well understood. Here we show that caspase-1-induced pyroptosis, a highly inflammatory programmed cell death pathway, is the dominant mechanism responsible for th
Autor:
Jinyan Liu, Jingyou Yu, Katherine McMahan, Catherine Jacob-Dolan, Xuan He, Victoria Giffin, Cindy Wu, Michaela Sciacca, Olivia Powers, Felix Nampanya, Jessica Miller, Michelle Lifton, David Hope, Kevin Hall, Nicole P. Hachmann, Benjamin Chung, Tochi Anioke, Wenjun Li, Jeanne Muench, Adrienne Gamblin, Mona Boursiquot, Anthony Cook, Mark G. Lewis, Hanne Andersen, Dan H. Barouch
Publikováno v:
Science immunology. 7(77)
Spike-specific neutralizing antibodies (NAbs) are generally considered key correlates of vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recently, robust vaccine prevention of severe disease with SAR
Autor:
Xuan He, Malika Aid, Abishek Chandrashekar, Jingyou Yu, Katherine McMahan, Frank Wegmann, Catherine Jacob-Dolan, Jenny S. Maron, Caroline Atyeo, Huahua Wan, Daniel Sellers, Jinyan Liu, Michelle Lifton, Sarah Gardner, Esther A. Bondzie, Julia Barrett, Kunza Ahmad, Tochi Anioke, Jake Yalley-Ogunro, Jeanne Muench, Adrienne Goode, Hanne Andersen, Mark G. Lewis, Galit Alter, Hanneke Schuitemaker, Roland Zahn, Dan H. Barouch
Publikováno v:
Science Translational Medicine. 14
Ad26.COV2.S has demonstrated durability and clinical efficacy against symptomatic COVID-19 in humans. In this study, we report the correlates of durability of humoral and cellular immune responses in 20 rhesus macaques immunized with single-shot Ad26
Autor:
Abishek Chandrashekar, Jingyou Yu, Katherine McMahan, Catherine Jacob-Dolan, Jinyan Liu, Xuan He, David Hope, Tochi Anioke, Julia Barrett, Benjamin Chung, Nicole P. Hachmann, Michelle Lifton, Jessica Miller, Olivia Powers, Michaela Sciacca, Daniel Sellers, Mazuba Siamatu, Nehalee Surve, Haley VanWyk, Huahua Wan, Cindy Wu, Laurent Pessaint, Daniel Valentin, Alex Van Ry, Jeanne Muench, Mona Boursiquot, Anthony Cook, Jason Velasco, Elyse Teow, Adrianus C.M. Boon, Mehul S. Suthar, Neharika Jain, Amanda J. Martinot, Mark G. Lewis, Hanne Andersen, Dan H. Barouch
Publikováno v:
bioRxiv
BackgroundThe rapid spread of the SARS-CoV-2 Omicron (B.1.1.529) variant, including in highly vaccinated populations, has raised important questions about the efficacy of current vaccines. Immune correlates of vaccine protection against Omicron are n
Autor:
Jinyan Liu, Abishek Chandrashekar, Daniel Sellers, Julia Barrett, Michelle Lifton, Katherine McMahan, Michaela Sciacca, Haley VanWyk, Cindy Wu, Jingyou Yu, Ai-ris Y. Collier, Dan H. Barouch
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 Spike immunogen1, resulting in increased breakthrough in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a419c4a2ab2d9fd492d6a54a85e3997
https://doi.org/10.1101/2022.01.02.22268634
https://doi.org/10.1101/2022.01.02.22268634