Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Michelle Leland"'
Autor:
Mark Z. Kos, Melanie A. Carless, Lucy Blondell, M. Michelle Leland, Koyle D. Knape, Harald H. H. Göring, Charles Ákos Szabó
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
In this study, we investigate the genetic determinants that underlie epilepsy in a captive baboon pedigree and evaluate the potential suitability of this non-human primate model for understanding the genetic etiology of human epilepsy. Archived whole
Externí odkaz:
https://doaj.org/article/ea7bcb588835406e8f7b81932b91751b
Autor:
C. Ákos Szabó, Karl Li, Felipe S. Salinas, Peter T. Fox, Crystal Franklin, M. Michelle Leland, Angela R. Laird, Shalini Narayana
Publikováno v:
Brain Structure and Function. 221:2023-2033
The baboon provides a model of photosensitive, generalized epilepsy. This study compares cerebral blood flow responses during intermittent light stimulation (ILS) between photosensitive (PS) and healthy control (CTL) baboons using H 2 15 O-PET. We ex
Autor:
Lindsey Koele-Schmidt, Steven R. Seidner, Cynthia L. Blanco, Alvaro Moreira, M. Michelle Leland
Publikováno v:
Pediatric Anesthesia. 24:840-844
Summary Objective To compare the ability to successfully intubate extremely preterm baboons using conventional direct laryngoscopy (DL) vs videolaryngoscopy. Methods A prospective randomized crossover study using experienced and inexperienced neonata
Autor:
M. Michelle Leland, Jeff T. Williams, C. Ákos Szabó, Jean-Louis Caron, Martha A. Hanes, Dongbin Xie, Felipe S. Salinas, Koyle D. Knape
Publikováno v:
Epilepsy Research. 101:46-55
The baboon provides a natural non-human primate model for photosensitive, generalized epilepsy. This study describes an implantation procedure for the placement of subdural grid and strip electrodes for continuous video-EEG monitoring in the epilepti
Autor:
T. J. C. Anderson, Ram Prasad Upadhayay, Daniel Sudimack, M. Michelle Leland, Joel D. Anderson, Jeff T. Williams, Shalini Nair
Publikováno v:
Journal of Parasitology. 98:205-208
We conducted cross-sectional surveys of parasites infecting a large free-living colony of baboons at the Southwest National Primate Research Center in San Antonio in October 2003 and April 2004, immediately before, and 6 mo after, treatment with iver
Publikováno v:
The Open Neuroimaging Journal
The goal of this study was to develop a clinically relevant non-human primate (baboon) stroke model and multi-parametric MRI protocols on a clinical scanner with long-term goals to better model human stroke and facilitate clinical translations of nov
Autor:
M. Michelle Leland, Koyle D. Knape, Charles Ákos Szabó, Peter T. Fox, Jeffrey Rogers, Jeff T. Williams, Jack L. Lancaster, K. J M McCoy, Peter Kochunov
Publikováno v:
Epilepsy Research. 93:91-95
Summary Brain MRI studies in people with idiopathic generalized epilepsies demonstrate regional morphometric differences, though variable in magnitude and location. As the baboon provides an excellent electroclinical and neuroimaging model for photos
Autor:
Gene B. Hubbard, Karin J.M. McCoy, Jake Feldman, Koyle D. Knape, M. Michelle Leland, C. Ákos Szabó, Jeff T. Williams
Publikováno v:
Epilepsia. 50:1995-1998
Because the baboon is a model of primary generalized epilepsy, we were interested in mortality of captive animals with a history of witnessed seizures. Causes of natural death were investigated in 46 seizure baboons (SZ) and 78 nonepileptic controls
Autor:
Richard O'Shaughnessy, Saju Joy, Patrice A. Frost, Natalia Schlabritz-Loutsevitch, M. Michelle Leland, Patty Fan-Havard
Publikováno v:
Journal of Medical Primatology. 38:151-155
The primate model continues to be an essential component of clinical research. The baboons (Papio cynocephalus) have been of particular interest due to their similarities with human placentation and fetal development.1 Fetal blood sampling allows the
Autor:
Gary E. Stapleton, Charles E. Mullins, M. Michelle Leland, Philip Ng, Donna Palmer, Milton J. Finegold, Viraj Mane, Nicola Brunetti-Pierri, Arthur L. Beaudet, Yu Zuo
Publikováno v:
Molecular Therapy. 15(4):732-740
Helper-dependent adenoviral vectors (HDAds) are attractive for liver-directed gene therapy because they can mediate long-term, high-level transgene expression without chronic toxicity. However, systemic delivery requires high vector doses for efficie