Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Michelle L. Wennerholm"'
Autor:
Sandra R. Chaplan, Brian Scott, Michele C. Rizzolio, Joan Pierce, Natalie A. Hawryluk, Mark Seierstad, Leon Chang, J. Guy Breitenbucher, Michelle L. Wennerholm, Mark J. Karbarz, Richard Apodaca, Sandy J. Wilson, John M. Keith, James A. Palmer, Allison Chambers, Michael Webb, Lin Luo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1280-1284
A series of 1-aryl-2-(((6-aryl)pyrimidin-4-yl)amino)ethanols have been found to be competitive inhibitors of fatty acid amide hydrolase (FAAH). One member of this class, JNJ-40413269, was found to have excellent pharmacokinetic properties, demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc169c27063de79ede8ba3a615dade39
https://doi.org/10.1016/j.bmcl.2014.01.064
https://doi.org/10.1016/j.bmcl.2014.01.064
Autor:
Sandy J. Wilson, Brian Scott, Mark S. Tichenor, Michele C. Rizzolio, Sandra R. Chaplan, Michael Webb, James A. Palmer, J. Guy Breitenbucher, Michelle L. Wennerholm, Raymond Rynberg, Mark Seierstad, Wei Xiao, Mark J. Karbarz, Richard Apodaca, John M. Keith, William M. Jones, Joan Pierce
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(13)
The SAR of brain penetration for a series of heteroaryl piperazinyl- and piperadinyl-urea fatty acid amide hydrolase (FAAH) inhibitors is described. Brain/plasma (B/P) ratios ranging from >4:1 to as low as 0.02:1 were obtained through relatively simp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ae76e3b864bc6dbfc824e2ac203ac5
https://pubmed.ncbi.nlm.nih.gov/27189675
https://pubmed.ncbi.nlm.nih.gov/27189675
Autor:
John M. Keith, Sandy J. Wilson, Michelle L. Wennerholm, William M. Jones, Raymond Rynberg, Leon Chang, Breitenbucher Jg, Jing Liu, Michael Webb, Lin Luo, Brian Scott, Mark S. Tichenor, Michele C. Rizzolio, Chaplan, James A. Palmer, Mark J. Karbarz, Mark Seierstad
Publikováno v:
ACS medicinal chemistry letters. 6(12)
The pre-clinical characterization of the aryl piperazinyl urea inhibitor of fatty acid amide hydrolase (FAAH) JNJ-42165279 is described. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4078e5fe9c66c21caee1f97bc3ebf2b0
https://pubmed.ncbi.nlm.nih.gov/26713105
https://pubmed.ncbi.nlm.nih.gov/26713105