Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michelle L. Steinhilb"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Neurodegenerative diseases represent a formidable challenge to global health. As advances in other areas of medicine grant healthy living into later decades of life, aging diseases such as Alzheimer's disease (AD) and other neurodegenerative disorder
Externí odkaz:
https://doaj.org/article/39019b2fd75649b2973ff4c54bbd636b
Autor:
James B Reinecke, Sarah L DeVos, James P McGrath, Amanda M Shepard, Dustin K Goncharoff, Don N Tait, Samantha R Fleming, Michael P Vincent, Michelle L Steinhilb
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23865 (2011)
Alzheimer's disease and other related neurodegenerative disorders known as tauopathies are characterized by the accumulation of abnormally phosphorylated and aggregated forms of the microtubule-associated protein tau. Several laboratories have identi
Externí odkaz:
https://doaj.org/article/6b18e7488c294543af57f18c848bbca1
Autor:
Madison A. Koon, Michelle L. Steinhilb, Khadijah Almohammed Ali, James P. McGrath, Robert M. Speaker, Eric W. Linton
Publikováno v:
Journal of Visualized Experiments.
Scanning electron microscopy (SEM) is a widely available technique that has been applied to study biological specimens ranging from individual proteins to cells, tissues, organelles, and even whole organisms. This protocol focuses on two chemical dry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99792c2ac86e6797aa425f9611cda21d
https://doi.org/10.3791/58761
https://doi.org/10.3791/58761
Publikováno v:
Methods in cell biology. 141
The fruit fly, Drosophila melanogaster, is a powerful model system for applying molecular, cellular, and genetic approaches to understanding human tauopathies, including Alzheimer's disease. Here, we provide an introduction to using Drosophila as a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01309680466417761a78b6eabf03a09e
https://pubmed.ncbi.nlm.nih.gov/28882306
https://pubmed.ncbi.nlm.nih.gov/28882306
The fruit fly, Drosophila melanogaster, is a powerful model system for applying molecular, cellular, and genetic approaches to understanding human tauopathies, including Alzheimer's disease. Here, we provide an introduction to using Drosophila as a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::849fb267c0f7f08e4e2090705bba22f2
https://doi.org/10.1016/bs.mcb.2017.06.006
https://doi.org/10.1016/bs.mcb.2017.06.006
Autor:
Eva Maria Mandelkow, Dora Dias-Santagata, Joshua M. Shulman, Mel B. Feany, Jacek Biernat, Michelle L. Steinhilb, Erin E. Mulkearns
Publikováno v:
Journal of Neuroscience Research. 85:1271-1278
The microtubule-associated protein tau is hyperphosphorylated abnormally in AD and related neurodegenerative disorders. Many phospho epitopes created by proline directed kinases (SP/TP sites) show relative specificity for disease states. To test whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c14d6d66583839b8988a6a33de0e97
https://doi.org/10.1002/jnr.21232
https://doi.org/10.1002/jnr.21232
Autor:
Michelle L. Steinhilb, Sean Oldham, Vikram Khurana, Joshua M. Shulman, Mel B. Feany, Yiran Lu
Publikováno v:
Current Biology. 16:230-241
Summary Background Previous studies have demonstrated reexpression of cell-cycle markers within postmitotic neurons in neurodegenerative tauopathies, including Alzheimer's disease (AD). However, the critical questions of whether cell-cycle activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3808577deb8334901edb6e04a02851f2
https://doi.org/10.1016/j.cub.2005.12.042
https://doi.org/10.1016/j.cub.2005.12.042
Publikováno v:
Journal of Neurochemistry. 80:1019-1028
Limiting beta amyloid (Abeta) production could become an important therapeutic target in Alzheimer's disease (AD). Abeta is derived by the sequential cleavage of amyloid precursor protein (APP) by beta- and gamma-secretases. A double missense mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5359ef6eeb1d02cfebd0a45720aebf8
https://doi.org/10.1046/j.0022-3042.2002.00764.x
https://doi.org/10.1046/j.0022-3042.2002.00764.x
Publikováno v:
Molecular biology of the cell. 18(12)
Tau is a microtubule binding protein implicated in a number of human neurodegenerative disorders, including Alzheimer's disease. Phosphorylation of serine-proline/threonine-proline sites, targeted by proline-directed kinases, coincides temporally wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802bbfdc8d242711de2830a6937b5f80
http://ora.ox.ac.uk/objects/uuid:142f0fc4-89b7-4dc4-8c32-a58cd90e9d84
http://ora.ox.ac.uk/objects/uuid:142f0fc4-89b7-4dc4-8c32-a58cd90e9d84
Autor:
James R. Gaut, Edward L. Stuenkel, Chi S. Ho, R. Scott Turner, Michelle L. Steinhilb, Vlad Marinescu
Publikováno v:
The Journal of biological chemistry. 277(30)
X11 proteins have been shown to modulate metabolism of the amyloid precursor protein (APP) and to reduce the secretion of beta-amyloid peptides (Abeta) that are associated with Alzheimer's disease. Whereas X11alpha interacts with APP via its phosphot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e289ea06cfadca9e1c6560a3ba9ce488
https://pubmed.ncbi.nlm.nih.gov/12016213
https://pubmed.ncbi.nlm.nih.gov/12016213