Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michelle L. Rose"'
Autor:
Scott Foster, Michelle L. Rose, Jody M. Khouri, Stephen J. Godin, Lawrence C. Trost, James Long, Laurie Keilholz
Publikováno v:
Antiviral Research. 117:115-121
Brincidofovir (BCV) has broad-spectrum in vitro activity against dsDNA viruses, including smallpox, and is being developed as a treatment for smallpox as well as infections caused by other dsDNA viruses. BCV has previously been shown to be active in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a30849fe8246b96ce93889383d555e6
https://doi.org/10.1016/j.antiviral.2015.02.007
https://doi.org/10.1016/j.antiviral.2015.02.007
Publikováno v:
Carcinogenesis. 21:823-826
Peroxisome proliferators increase hepatocyte proliferation and cause liver tumors in rodents, yet the mechanism of action is not understood. Based on studies with null mice it is known that peroxisome proliferator-activated receptor-alpha (PPARalpha)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ac1c2b5789db66b649a23dd83f895b
https://doi.org/10.1093/carcin/21.4.823
https://doi.org/10.1093/carcin/21.4.823
Autor:
Ivan Rusyn, Michelle L. Rose, Jennifer Belyea, Heidi K. Bojes, Ronald G. Thurman, Russell C. Cattley
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 448:179-192
There is widespread human exposure to peroxisome proliferators, which are structurally diverse compounds. Peroxisome proliferators received their name based on their ability to induce proliferation of w x peroxisomes in rodent hepatocytes 1 ; they in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae8a070b365227f5d5b9703d8d7e216
https://doi.org/10.1016/s0027-5107(99)00235-3
https://doi.org/10.1016/s0027-5107(99)00235-3
Autor:
Michael D. Wheeler, Ronald G. Thurman, Vítor Seabra, Peter Schemmer, Nobuyuki Enomoto, Blair U. Bradford, K. Ikejema, Ming Yin, Zhi Zhong, Ivan Rusyn, Michelle L. Rose, R. F. Stacklewitz
Publikováno v:
CIÊNCIAVITAE
Scopus-Elsevier
Scopus-Elsevier
The mechanism of the immunosuppressive effects of glycine and its pathophysiological applications are discussed in this review. Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67f870f94d53bcaeebc4140c7fed4a5
https://doi.org/10.1007/s000180050030
https://doi.org/10.1007/s000180050030
Publikováno v:
Expert Opinion on Therapeutic Patents. 9:1223-1236
Diabetes is a significant healthcare problem worldwide and its incidence is rising. Type 2 diabetes patients are at significant risk of developing additional major diseases, especially obesity, hypertension, and dyslipidaemia. All of these conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1988a3e4944e029aa24e389d7a3a8712
https://doi.org/10.1517/13543776.9.9.1223
https://doi.org/10.1517/13543776.9.9.1223
Autor:
James A. Raleigh, Michelle L. Rose, Hartwig Bunzendahl, John J. Lemasters, Peter Schemmer, Blair U. Bradford, Ronald G. Thurman
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 276:G924-G932
In situ manipulation by touching, retracting, and moving liver lobes gently during harvest dramatically reduces survival after transplantation (P. Schemmer, R. Schoonhoven, J. A. Swenberg, H. Bunzendahl, and R. G. Thurman. Transplantation 65: 1015–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea9d91e8dcf201b0d6b89778dc6385d
https://doi.org/10.1152/ajpgi.1999.276.4.g924
https://doi.org/10.1152/ajpgi.1999.276.4.g924
Autor:
Ivan Rusyn, Michelle L. Rose, Michael I. Luster, Heidi K. Bojes, Ronald G. Thurman, Dori R. Germolec
Publikováno v:
Drug Metabolism Reviews. 31:87-116
Peroxisome proliferators are a group of structurally diverse compounds that cause an increase in both the number and size of peroxisomes, elevate rates of cell proliferation, and cause liver cancer...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bfe73a482e81256b8d6da7a32705cd
https://doi.org/10.1081/dmr-100101909
https://doi.org/10.1081/dmr-100101909
Autor:
James A. Swenberg, Michelle L. Rose, Ronald G. Thurman, Lee M. Graves, Robert Schoonhoven, Russell C. Cattley, Blair U. Bradford, Chantal A. Rivera
Publikováno v:
Carcinogenesis. 20:27-33
Increased cell proliferation most likely plays a key role in peroxisome proliferator-induced liver cancer. Recently, Kupffer cells were shown to be responsible for Wy-14,643induced cell proliferation. However, the mechanism by which peroxisome prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65933880488cfbb0bdb2922ef7d39516
https://doi.org/10.1093/carcin/20.1.27
https://doi.org/10.1093/carcin/20.1.27
Publikováno v:
Carcinogenesis. 18:1453-1456
WY-14,643 [4-chloro-6-(2,3-xylidino)pyrimidinylthio-acetic acid] is a well-known non-genotoxic carcinogen and peroxisome proliferator that causes liver cancer in rodents by unknown mechanisms. Its ability to sustain elevated rates of hepatocyte DNA s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165b5068f74f40bcbdebdcb68faca22b
https://doi.org/10.1093/carcin/18.8.1453
https://doi.org/10.1093/carcin/18.8.1453
Publikováno v:
Hepatology. 24:391-397
It has been shown recently that inactivation of Kupffer cells prevents free radical formation and early alcohol-induced liver injury, and that hypoxia subsequent to a hypermetabolic state caused by activated Kupffer cells is likely involved in the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee28914f79292dc6aa782f0fc48c8ca1
https://doi.org/10.1002/hep.510240217
https://doi.org/10.1002/hep.510240217