Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michelle L. L. Donnelly"'
Autor:
Lorraine E. Hughes, Vanessa M. Cowton, Garry A. Luke, Michelle L. L. Donnelly, Martin D. Ryan, Amit P. Mehrotra, Xuejun Li, Edwin ten Dam, David Gani
In the case of the aphtho- and cardioviruses, the primary cleavage in the region of the polyprotein was known to be different, occurring at the C terminus of 2A. Precursor forms spanning the 2A/2B junction are not observed in aphtho- or cardiovirus p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f76a41fdc37307062b4f07641a37156f
https://doi.org/10.1128/9781555817916.ch18
https://doi.org/10.1128/9781555817916.ch18
Autor:
Michelle L. L. Donnelly, Arwel Lewis, Amit P. Mehrotra, Martin D. Ryan, David Gani, John Wilkie
Publikováno v:
Bioorganic Chemistry. 27:55-79
The aphthovirus 2A region apparently responsible for the hydrolytic cleavage of a single large polyprotein at a Gly-Pro linkage is only 18 amino acid residues long and is evidently not a proteinase. Here we describe the construction of reporter recom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d34d246332621f678cbc19b71105f2
https://doi.org/10.1006/bioo.1998.1119
https://doi.org/10.1006/bioo.1998.1119
Publikováno v:
Scopus-Elsevier
The primary 2A/2B polyprotein cleavage of aphtho-and cardioviruses is mediated by their 2A proteins cleaving C-terminally. Whilst the aphthovirus 2A region is only 16 aa (possibly 18 aa) long, the cardiovirus 2A protein is some 150 aa. We have previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e77d85fa3f5899fde69fd38ffc928c
https://doi.org/10.1099/0022-1317-78-1-13
https://doi.org/10.1099/0022-1317-78-1-13
Autor:
David Gani, Garry A. Luke, Amit P. Mehrotra, Xuejun Li, Lorraine E. Hughes, Martin D. Ryan, Michelle L. L. Donnelly
Publikováno v:
University of St Andrews CRIS
The 2A region of the aphthovirus foot-and-mouth disease virus (FMDV) polyprotein is only 18 aa long. A ‘primary’ intramolecular polyprotein processing event mediated by 2A occurs at its own C terminus. FMDV 2A activity was studied in artificial p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39b0ef4ef834436d9704c917e4448e0
https://risweb.st-andrews.ac.uk/portal/en/researchoutput/analysis-of-the-aphthovirus-2a2b-polyprotein-cleavage-mechanism-indicates-not-a-proteolytic-reaction-but-a-novel-translational-effect-a-putative-ribosomal-skip(1d328ed4-37ac-436c-bca7-97bbf61242bd).html
https://risweb.st-andrews.ac.uk/portal/en/researchoutput/analysis-of-the-aphthovirus-2a2b-polyprotein-cleavage-mechanism-indicates-not-a-proteolytic-reaction-but-a-novel-translational-effect-a-putative-ribosomal-skip(1d328ed4-37ac-436c-bca7-97bbf61242bd).html