Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michelle L. Janas"'
Publikováno v:
PLoS ONE, Vol 8, Iss 5 (2013)
Externí odkaz:
https://doaj.org/article/fe801bb89af54ff0b407c2317a401f7c
Autor:
Martin R Turner, Michelle L. Janas
Publikováno v:
Trends in Immunology. 31:370-376
The progressive maturation of T cells is accompanied by their migration through the thymus, with each selection stage occurring in distinct microenvironments. Many specialized receptor-ligand pairs have been defined that drive T cell differentiation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251e79ffe45fcd49c8fdec3f4f0a6886
https://doi.org/10.1016/j.it.2010.07.002
https://doi.org/10.1016/j.it.2010.07.002
Autor:
Amy Saunders, Martin R Turner, Nicholas Pugh, Christine Carter, Louise M. C. Webb, Amanda Hutchings, John C. Pascall, Michelle L. Janas, Geoffrey W. Butcher, Geoff Morgan
Publikováno v:
Blood. 115:3249-3257
The guanosine triphosphatases (GTPases) of the immunity-associated protein (GIMAP) family of putative GTPases has been implicated in the regulation of T-lymphocyte development and survival. A mouse conditional knockout allele was generated for the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a7b79eb619c56c4e2946b1a9a78aee
https://doi.org/10.1182/blood-2009-08-237586
https://doi.org/10.1182/blood-2009-08-237586
Autor:
Anne Kelso, Michelle L. Janas, Norbert Kienzle, Stuart D. Olver, Kathy Buttigieg, Edward S. Morris, Penny Groves
Publikováno v:
Cancer Research. 66:571-580
An interleukin (IL)-4-containing tumor environment is reported to be beneficial for immune clearance of tumor cells in vivo; however, the effect of IL-4 on the effector CD8+ T cells contributing to tumor clearance is not well defined. We have used th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ab848337440067b4ed2579662ad588
https://doi.org/10.1158/0008-5472.can-05-1362
https://doi.org/10.1158/0008-5472.can-05-1362
Publikováno v:
The Journal of Immunology. 175:8003-8010
Perforin and the serine protease granzymes are key effectors of CD8+ T cell granule-mediated cytotoxicity, but the requirements for their expression remain largely undefined. We show in this study that IL-2 increased the expression of perforin and gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506fcc6857b207d93bc709ce7500ddea
https://doi.org/10.4049/jimmunol.175.12.8003
https://doi.org/10.4049/jimmunol.175.12.8003
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 5 (2013)
PLoS ONE, Vol 8, Iss 5 (2013)
There were errors in Figure 5 and Supporting Figures S4, S5, and S6. The correct versions of these Figures can be viewed here: Figure 5: Supporting Figure S4: Click here for additional data file.(15M, tif) Supporting Figure S5: Click here for additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d248cbff56098387c901708b6ad2a5
http://europepmc.org/articles/PMC3656667
http://europepmc.org/articles/PMC3656667
Autor:
Martin R Turner, Michelle L. Janas
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 187(9)
Thymocytes are tested for productive rearrangement of the tcrb locus by expression of a pre-TCR in a process termed β-selection, which requires both Notch1 and CXCR4 signaling. It has been shown that activation of the GTPase Ras allows thymocytes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e44cfdb0d636727a26eb163c776dd0e
https://pubmed.ncbi.nlm.nih.gov/21930962
https://pubmed.ncbi.nlm.nih.gov/21930962
Autor:
Klaus Okkenhaug, Sara Santinelli, Nigel Killeen, Julia Rolf, Dorottya Kövesdi, Michelle L. Janas, Dalya R. Soond, Louise M. C. Webb, Martin R Turner, Barbara Hebeis, Ted Saunders, Sarah Bell
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 185(7)
The generation of high-affinity Abs is essential for immunity and requires collaboration between B and T cells within germinal centers (GCs). By using novel mouse models with a conditional deletion of the p110δ catalytic subunit of the PI3K pathway,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f717ca186f3e723d1181eaae687e8f4
https://pubmed.ncbi.nlm.nih.gov/20826752
https://pubmed.ncbi.nlm.nih.gov/20826752
Autor:
Kristjan S. Gudmundsson, Mamiko Noda, Michelle L. Janas, Takashi Nagasawa, Martin R Turner, Gabriele Varano
Publikováno v:
The Journal of Experimental Medicine
T cell development requires phosphatidylinositol 3-kinase (PI3K) signaling with contributions from both the class IA, p110delta, and class IB, p110gamma catalytic subunits. However, the receptors on immature T cells by which each of these PI3Ks are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c10cdb7ffe28abec739f056f2f31001
http://hdl.handle.net/11392/2434615
http://hdl.handle.net/11392/2434615
Autor:
Michelle L. Janas, Endre Kiss-Toth, David C. Crossman, Katalin Eder, Hye Youn Sung, Steven K. Dower, Erno Duda, Jon R. Ward, Martin R Turner, Gabriella Sármay, Sheila E. Francis, Hongtao Guan, Adrienn Angyal
Publikováno v:
International Immunology
Inflammatory activation of monocytes is an essential part of both innate immune responses and the pathogenesis of conditions such as atherosclerosis. However, the mechanisms which modulate the response of monocytes to inflammatory stimuli are still p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41039d6778c1119d86d674a048884010