Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michelle L. Ho"'
Publikováno v:
Virology. 563:107-115
Adeno-associated virus (AAV) is a promising gene therapy vector, but questions remain regarding mechanisms of basic viral functions. We previously showed that a serine/threonine (S/T) triplet motif and its flanking residues, located in the overlappin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87d25a907dc5e1f42ebf50025b419cb
https://doi.org/10.1016/j.virol.2021.08.010
https://doi.org/10.1016/j.virol.2021.08.010
Autor:
Pui Pik Law, Liudmila A. Mikheeva, Francisco Rodriguez-Algarra, Fredrika Asenius, Maria Gregori, Robert A. E. Seaborne, Selin Yildizoglu, James R. C. Miller, Hemanth Tummala, Robin Mesnage, Michael N. Antoniou, Weilong Li, Qihua Tan, Sara L. Hillman, Vardhman K. Rakyan, David J. Williams, Michelle L. Holland
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Body mass results from a complex interplay between genetics and environment. Previous studies of the genetic contribution to body mass have excluded repetitive regions due to the technical limitations of platforms used for population scale s
Externí odkaz:
https://doaj.org/article/80eab87c54514fd3a8296ed1fbbcc98c
Autor:
E. Wu, Michelle L. Ho, Justin Judd, Caitlin M. Guenther, Jessica Tong, Annicka C. Evans, Junghae Suh, Mitchell J. Brun
Publikováno v:
J Control Release
Gene therapy is a promising strategy for treating metastatic epithelial ovarian cancer (EOC). However, efficient vector targeting to tumors is difficult and off-target effects can be severely detrimental. Most vector targeting approaches rely on surf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117f5bcd9995649e80557189268130aa
https://doi.org/10.1016/j.jconrel.2019.06.034
https://doi.org/10.1016/j.jconrel.2019.06.034
Autor:
Momona Yamagami, Mavis Agbandje-McKenna, Nilakshee Bhattacharya, Duncan Sousa, Sunkuk Kwon, Junghae Suh, Caitlin M. Guenther, Eva M. Sevick-Muraca, Julie Voss, Weitong Chen, Michael T Lam, Michelle L. Ho, Antonette Bennett, Banghe Zhu, Mitchell J. Brun, Annicka C. Evans
Publikováno v:
Molecular Therapy. 27:611-622
Adeno-associated virus (AAV) has emerged as a promising gene delivery vector because of its non-pathogenicity, simple structure and genome, and low immunogenicity compared to other viruses. However, its adoption as a safe and effective delivery vecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee89f633e78eed0b84a9266b3226c1af
https://doi.org/10.1016/j.ymthe.2019.01.015
https://doi.org/10.1016/j.ymthe.2019.01.015
Autor:
Junghae Suh, Byunguk Kang, Tawana M. Robinson, Kiara Reyes Gamas, Weitong Chen, Michelle L. Ho, Esther J. Lee, Anton Banta, Brian Wahlig, Veronica Gough
Publikováno v:
Virology
Adeno-associated virus (AAV) is one of the most researched, clinically utilized gene therapy vectors. Though clinical success has been achieved, transgene delivery and expression may be hindered by cellular and tissue barriers. Understanding the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858cdd841f83477a5450a55a35af0025
https://pubmed.ncbi.nlm.nih.gov/32452411
https://pubmed.ncbi.nlm.nih.gov/32452411
Publikováno v:
Virology. 510:1-8
Adeno-associated virus (AAV)-mediated gene transfer is an appealing therapeutic option due to AAV's safety profile. Effective delivery of AAV's genetic cargo to the nucleus, however, requires evasion of host cell barriers, including cellular clearanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7315dc936e14b89bacf246a3e11aab25
https://doi.org/10.1016/j.virol.2017.06.030
https://doi.org/10.1016/j.virol.2017.06.030
Publikováno v:
ACS Biomaterials Science & Engineering. 2:2026-2033
Protease-activatable viruses (PAV) based on adeno-associated virus have previously been generated for gene delivery to pathological sites characterized by elevated extracellular proteases. "Peptide locks", composed of a tetra-aspartic acid motif flan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b635f50673aa9a6c16789fafe33eec2
https://doi.org/10.1021/acsbiomaterials.6b00439
https://doi.org/10.1021/acsbiomaterials.6b00439
Autor:
Hiroshi Yamaguchi, Sonal Gupta, Bidyut Ghosh, Mitchell J. Brun, Takashi Okumura, Junghae Suh, Jonathon Huang, Anirban Maitra, Noboru Ideno, Michelle L. Ho
Genetically engineered mouse models (GEMMs) that recapitulate the major genetic drivers in pancreatic ductal adenocarcinoma (PDAC) have provided unprecedented insights into the pathogenesis of this lethal neoplasm. Nonetheless, generating an autochth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3eec7b8125ee1689fc99129a23559d0
https://doi.org/10.1101/398347
https://doi.org/10.1101/398347
Autor:
Junghae Suh, Justin Judd, Brianna E. Kuypers, Fergus F. Wong, Michelle L. Ho, Momona Yamagami
Publikováno v:
Cellular and Molecular Bioengineering. 7:334-343
Virus nanonodes, a tunable multi-input protease-responsive gene delivery platform, was recently built by exploiting the self-assembly property of adeno-associated virus capsids. Upon detection of specific inputs (e.g., matrix metalloproteinases—MMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::004d39f559de68b1f08acb713f0eec8a
https://doi.org/10.1007/s12195-014-0334-y
https://doi.org/10.1007/s12195-014-0334-y
Autor:
Kim Van Vliet, Junghae Suh, Michelle L. Ho, Jonathan J. Silberg, Eric J. Gomez, Mavis Agbandje-McKenna, Oleg A. Igoshin, Abhinav Tiwari, Christopher Dempsey, Justin Judd
Publikováno v:
ACS Nano
We explored the unique signal integration properties of the self-assembling 60-mer protein capsid of adeno-associated virus (AAV), a clinically proven human gene therapy vector, by engineering proteolytic regulation of virus–receptor interactions s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ab6366f7de366db965129714a59293
https://doi.org/10.1021/nn500550q
https://doi.org/10.1021/nn500550q