Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Michelle L. Ganno"'
Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping
Autor:
Eshita Khera, Cornelius Cilliers, Michael D. Smith, Michelle L. Ganno, Katharine C. Lai, Thomas A. Keating, Anna Kopp, Ian Nessler, Adnan O. Abu-Yousif, Greg M. Thurber
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely
Externí odkaz:
https://doaj.org/article/a1d49a829b1446a5941d3e371fc652ef
Autor:
Jay P. McLaughlin, Ramanjaneyulu Rayala, Ashley J. Bunnell, Mukund P. Tantak, Shainnel O. Eans, Khadija Nefzi, Michelle L. Ganno, Colette T. Dooley, Adel Nefzi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9623 (2022)
The design and development of analgesics with mixed-opioid receptor interactions has been reported to decrease side effects, minimizing respiratory depression and reinforcing properties to generate safer analgesic therapeutics. We synthesized bis-cyc
Externí odkaz:
https://doaj.org/article/048103fa04c04e789073971b3b5c242c
Autor:
Ariana C. Brice-Tutt, Sanjeewa N. Senadheera, Michelle L. Ganno, Shainnel O. Eans, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich
Publikováno v:
Molecules, Vol 25, Iss 17, p 3999 (2020)
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo. The present study evaluated the influence of the Phe residues’ stereochemistry on
Externí odkaz:
https://doaj.org/article/017a586349384007872af65cadb6d478
Autor:
O. Petter Veiby, Jennifer Fretland, Mark G. Qian, Jayaprakasam Bolleddula, Robbie Robertson, Maria Borland, Melissa Saylor Landen, Cindy Q. Xia, Andy Zhu, Secil Koseoglu, Kurt Eng, Afrand Kamali, Bradley Stringer, Thomas A. Keating, Katharine C. Lai, Michael D. Smith, Michelle L. Ganno, Bret M. Bannerman, Melissa Gallery, Donna Cvet, Adnan O. Abu-Yousif
Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7d56b0bf0e605a39ee70fc897c8b59
https://doi.org/10.1158/1535-7163.c.6542328.v1
https://doi.org/10.1158/1535-7163.c.6542328.v1
Autor:
O. Petter Veiby, Jennifer Fretland, Mark G. Qian, Jayaprakasam Bolleddula, Robbie Robertson, Maria Borland, Melissa Saylor Landen, Cindy Q. Xia, Andy Zhu, Secil Koseoglu, Kurt Eng, Afrand Kamali, Bradley Stringer, Thomas A. Keating, Katharine C. Lai, Michael D. Smith, Michelle L. Ganno, Bret M. Bannerman, Melissa Gallery, Donna Cvet, Adnan O. Abu-Yousif
Supplemental Figure 1: heavy and light chain sequences for 5F9, the human IgG1 monoclonal antibody (mAb) targeting the extracellular domain of GCC as described previously Supplemental Figure 2: Characterization of TAK-164 and chKTI-DGN549 by A) SDS P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc671e1a3ed72f6591ec22f46838181
https://doi.org/10.1158/1535-7163.22519161.v1
https://doi.org/10.1158/1535-7163.22519161.v1
Autor:
Bruna Menezes, Eshita Khera, Melissa Calopiz, Michael D. Smith, Michelle L. Ganno, Cornelius Cilliers, Adnan O. Abu-Yousif, Jennifer J. Linderman, Greg M. Thurber
Publikováno v:
The AAPS journal. 24(6)
The development of new antibody-drug conjugates (ADCs) has led to the approval of 7 ADCs by the FDA in 4 years. Given the impact of intratumoral distribution on efficacy of these therapeutics, coadministration of unconjugated antibody with ADC has be
Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping
Autor:
Katharine C. Lai, Michael D. Smith, Ian Nessler, Anna Kopp, Cornelius Cilliers, Thomas A. Keating, Adnan O. Abu-Yousif, Greg M. Thurber, Michelle L. Ganno, Eshita Khera
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 210-221 (2021)
With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely
Autor:
Bradley Stringer, Kurt Eng, Katharine C. Lai, Mark G. Qian, Jennifer Fretland, Melissa Gallery, Robbie Robertson, Melissa Saylor Landen, Cindy Q. Xia, Adnan O. Abu-Yousif, O. Petter Veiby, Afrand Kamali, Maria Borland, Secil Koseoglu, Bret Bannerman, Andy Z. X. Zhu, Michelle L. Ganno, Thomas A. Keating, Michael D. Smith, Donna Cvet, Jayaprakasam Bolleddula
Publikováno v:
Molecular Cancer Therapeutics. 19:2079-2088
Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is a
Autor:
Vicky A. Appleman, Allison J. Berger, Emily R. Roberts, Angel E. Maldonado-Lopez, Michelle L. Ganno, Camilla I. Christensen, Tiquella Hatten, Yosuke Sato, Michael H. Shaw, Karim S. Malek, Neil B. Lineberry, Adnan O. Abu-Yousif, Richard C. Gregory
Publikováno v:
Cancer Research. 82:3448-3448
Robust interferon (IFN) signaling is integral for productive immune-mediated anti-tumor responses; however, impaired IFN signaling has been linked to checkpoint inhibitor (CPI) resistance. The cyclic GMP-AMP Synthase (cGAS)-STimulator of InterferoN G
Autor:
Thomas F. Murray, Jay P. McLaughlin, Sanjeewa N. Senadheera, Shainnel O. Eans, Ariana C. Brice-Tutt, Tanvir Khaliq, Jane V. Aldrich, Michelle L. Ganno
Publikováno v:
Molecules
Volume 25
Issue 17
Molecules, Vol 25, Iss 3999, p 3999 (2020)
Volume 25
Issue 17
Molecules, Vol 25, Iss 3999, p 3999 (2020)
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo. The present study evaluated the influence of the Phe residues&rsquo
stereochemi
stereochemi