Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Michelle L. Badura"'
Autor:
Jonathan Chou, Kai Trepka, Martin Sjöström, Emily A. Egusa, Carissa E. Chu, Jun Zhu, Emily Chan, Ewan A. Gibb, Michelle L. Badura, Alberto Contreras-Sanz, Bradley A. Stohr, Maxwell V. Meng, Raj S. Pruthi, Yair Lotan, Peter C. Black, Sima P. Porten, Vadim S. Koshkin, Terence W. Friedlander, Felix Y. Feng
Publikováno v:
European Urology Oncology. 5:714-718
Sacituzumab govitecan (SG) is an antibody-drug conjugate (ADC) targeting TROP2, which has recently been approved for treatment-refractory metastatic urothelial cancer (UC). However, the variability of TROP2 expression across different bladder cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8982e76ccd29a9ac4c02099a653bc1e7
https://doi.org/10.1016/j.euo.2021.11.005
https://doi.org/10.1016/j.euo.2021.11.005
Autor:
Jonathan Chou, Emily A. Egusa, Sinan Wang, Michelle L. Badura, Fei Lee, Anil P. Bidkar, Jun Zhu, Tanushree Shenoy, Kai Trepka, Troy M. Robinson, Veronica Steri, Jiaoti Huang, Yuzhuo Wang, Eric J. Small, Emily Chan, Bradley A. Stohr, Alan Ashworth, Brant Delafontaine, Sylvie Rottey, Keegan S. Cooke, Nooshin Hashemi Sadraei, Brian Yu, Mark Salvati, Julie M. Bailis, Felix Y. Feng, Robert R. Flavell, Rahul Aggarwal
Publikováno v:
Cancer Research. 83:301-315
Effective treatments for de novo and treatment-emergent small-cell/neuroendocrine (t-SCNC) prostate cancer represent an unmet need for this disease. Using metastatic biopsies from patients with advanced cancer, we demonstrate that delta-like ligand 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd84ff0076818d35ace7788f4b37165
https://doi.org/10.1158/0008-5472.can-22-1433
https://doi.org/10.1158/0008-5472.can-22-1433
Autor:
Yang Yang, Michelle L. Badura, Patrick O’Leary, Troy M. Robinson, Emily A. Egusa, Xiaoming Zhong, Jason T. Swinderman, Haolong Li, Meng Zhang, Minkyu Kim, Alan Ashworth, Felix Y. Feng, Jonathan Chou, Lixing Yang
Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their formation remain unclear. Here, we use 6,193 whole-genome sequenced tumors to study the contributions of transcription and DNA replic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f71620428625705bd160dfcf590bf5b
https://doi.org/10.1101/2023.05.17.23290140
https://doi.org/10.1101/2023.05.17.23290140
Autor:
Jonathan Chou, Felix Y. Feng, Sima P. Porten, Peter C. Black, Yair Lotan, Terence W. Friedlander, Raj S. Pruthi, Maxwell V. Meng, Bradley A. Stohr, Vadim S. Koshkin, Jun Zhu, Michelle L. Badura, Ewan A. Gibb, Emily A. Egusa, Martin Sjöström, Carissa E. Chu
NECTIN4 mRNA gene expression across the (A) TCGA, (B) Decipher, and (C) Lund molecular subtypes in the Decipher commercial cohort (n=529). The p value from Kruskal-Wallis testing is shown for each panel.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bc524ce4f40c2dcf3c2291c5390739
https://doi.org/10.1158/1078-0432.22481595
https://doi.org/10.1158/1078-0432.22481595
Autor:
Jonathan Chou, Felix Y. Feng, Sima P. Porten, Peter C. Black, Yair Lotan, Terence W. Friedlander, Raj S. Pruthi, Maxwell V. Meng, Bradley A. Stohr, Vadim S. Koshkin, Jun Zhu, Michelle L. Badura, Ewan A. Gibb, Emily A. Egusa, Martin Sjöström, Carissa E. Chu
(A) Validation of knockdown by cell surface staining of NECTIN4 protein expression in HT-1376 cells using CRISPRi/dCas9 and five unique sgRNAs targeting different regions of NECTIN4 gene and promoter. The sgNECTIN4-a guide was used for subsequent exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e4dca604296efdcff49372c466f79e
https://doi.org/10.1158/1078-0432.22481571.v1
https://doi.org/10.1158/1078-0432.22481571.v1
Autor:
Rahul Aggarwal, Robert R. Flavell, Felix Y. Feng, Julie M. Bailis, Mark Salvati, Brian Yu, Nooshin Hashemi Sadraei, Keegan S. Cooke, Sylvie Rottey, Brant Delafontaine, Alan Ashworth, Bradley A. Stohr, Emily Chan, Eric J. Small, Yuzhuo Wang, Jiaoti Huang, Veronica Steri, Troy M. Robinson, Kai Trepka, Tanushree Shenoy, Jun Zhu, Anil P. Bidkar, Fei Lee, Michelle L. Badura, Sinan Wang, Emily A. Egusa, Jonathan Chou
Effective treatments for de novo and treatment-emergent small-cell/neuroendocrine (t-SCNC) prostate cancer represent an unmet need for this disease. Using metastatic biopsies from patients with advanced cancer, we demonstrate that delta-like ligand 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637631395292baf4918a236d81eca75d
https://doi.org/10.1158/0008-5472.c.6514325
https://doi.org/10.1158/0008-5472.c.6514325
Autor:
Rahul Aggarwal, Robert R. Flavell, Felix Y. Feng, Julie M. Bailis, Mark Salvati, Brian Yu, Nooshin Hashemi Sadraei, Keegan S. Cooke, Sylvie Rottey, Brant Delafontaine, Alan Ashworth, Bradley A. Stohr, Emily Chan, Eric J. Small, Yuzhuo Wang, Jiaoti Huang, Veronica Steri, Troy M. Robinson, Kai Trepka, Tanushree Shenoy, Jun Zhu, Anil P. Bidkar, Fei Lee, Michelle L. Badura, Sinan Wang, Emily A. Egusa, Jonathan Chou
FigureS7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834d9df1db0096d6d2410b8c2644c6e6
https://doi.org/10.1158/0008-5472.22433267
https://doi.org/10.1158/0008-5472.22433267
Autor:
Rahul Aggarwal, Robert R. Flavell, Felix Y. Feng, Julie M. Bailis, Mark Salvati, Brian Yu, Nooshin Hashemi Sadraei, Keegan S. Cooke, Sylvie Rottey, Brant Delafontaine, Alan Ashworth, Bradley A. Stohr, Emily Chan, Eric J. Small, Yuzhuo Wang, Jiaoti Huang, Veronica Steri, Troy M. Robinson, Kai Trepka, Tanushree Shenoy, Jun Zhu, Anil P. Bidkar, Fei Lee, Michelle L. Badura, Sinan Wang, Emily A. Egusa, Jonathan Chou
FigureS3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3ec1ca0155a9a8f18c86e9b15b398e
https://doi.org/10.1158/0008-5472.22433279
https://doi.org/10.1158/0008-5472.22433279
Autor:
Jonathan Chou, Felix Y. Feng, Sima P. Porten, Peter C. Black, Yair Lotan, Terence W. Friedlander, Raj S. Pruthi, Maxwell V. Meng, Bradley A. Stohr, Vadim S. Koshkin, Jun Zhu, Michelle L. Badura, Ewan A. Gibb, Emily A. Egusa, Martin Sjöström, Carissa E. Chu
(A) NECTIN4 surface protein expression in TCCSUP Control and TCCSUP NECTIN4 OE cells. (B) EV dose-response clonogenic assay in TCCSUP Control and TCCSUP NECTIN4 OE cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5202520693e1957e5d6f4c29f280b1f8
https://doi.org/10.1158/1078-0432.22481592.v1
https://doi.org/10.1158/1078-0432.22481592.v1
Autor:
Jonathan Chou, Felix Y. Feng, Sima P. Porten, Peter C. Black, Yair Lotan, Terence W. Friedlander, Raj S. Pruthi, Maxwell V. Meng, Bradley A. Stohr, Vadim S. Koshkin, Jun Zhu, Michelle L. Badura, Ewan A. Gibb, Emily A. Egusa, Martin Sjöström, Carissa E. Chu
The p values from pairwise comparisons amongst the molecular subtypes for each cohort using the Wilcoxon rank-sum test are shown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193b671bbb4ae9138feee5a5a7d1d886
https://doi.org/10.1158/1078-0432.22481559
https://doi.org/10.1158/1078-0432.22481559