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pro vyhledávání: '"Michelle L. Altrich-VanLith"'
Publikováno v:
The Journal of Immunology. 182:4830-4835
We recently demonstrated that the mechanism of processing of an HLA-A*0201-restricted peptide epitope, Tyr369(D), derived from the membrane protein tyrosinase, involves retrotranslocation of glycosylated molecules from the endoplasmic reticulum to th
Autor:
Joy M. Polefrone, Marina Ostankovitch, Michelle L. Altrich-VanLith, Victor H. Engelhard, Claudio A. Mosse, Donald F. Hunt, Jeffrey Shabanowitz
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 177(8)
Although multiple components of the class I MHC processing pathway have been elucidated, the participation of nonproteasomal cytosolic enzymes has been largely unexplored. In this study, we provide evidence for multiple cytosolic mechanisms in the ge
Publikováno v:
Current opinion in immunology. 18(1)
A variety of different post-translational modifications of peptides displayed by class I and II MHC molecules have now been described. Some modifications promote the binding of peptides to MHC molecules, and might also influence the ability of the pe