Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Michelle L McCully"'
Autor:
Zoë Wallace, Jakub Kopycinski, Hongbing Yang, Michelle L. McCully, Christian Eggeling, Jakub Chojnacki, Lucy Dorrell
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract T cell exhaustion develops in human immunodeficiency virus (HIV) infection due to chronic viral antigenic stimulation. This adaptive response primarily affects virus-specific CD8+ T cells, which may remain dysfunctional despite viral load-re
Externí odkaz:
https://doaj.org/article/fdde8440cb184babaf7c956ef964feda
Autor:
Adam P. Curnock, Giovanna Bossi, Jyothi Kumaran, Lindsay J. Bawden, Rita Figueiredo, Rajeevkumar Tawar, Katherine Wiseman, Emma Henderson, Sec Julie Hoong, Veronica Gonzalez, Hemza Ghadbane, David E.O. Knight, Ronan O’Dwyer, David X. Overton, Christina M. Lucato, Nicola M.G. Smith, Carlos R. Reis, Keith Page, Lorraine M. Whaley, Michelle L. McCully, Stephen Hearty, Tara M. Mahon, Peter Weber
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but progress in this area has been limited. Here, we generated T cell recepto
Externí odkaz:
https://doaj.org/article/76d2b586086f49e3988424380f1b73ad
Publikováno v:
The Febs Journal
Immunotherapy approaches that target peptide–human leukocyte antigen (pHLA) complexes are becoming highly attractive because of their potential to access virtually all foreign and cellular proteins. For this reason, there has been considerable inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce182025f7d9bf9389ad8d474ece5ac9
http://europepmc.org/articles/PMC8596704
http://europepmc.org/articles/PMC8596704
Autor:
R. Martinez Hague, Fiona Chester, Jane Harper, S. Griffin, Angharad Lloyd, Emma Baston, R. Mulvaney, Annelise Vuidepot, K. Smith, S. Harper, K. Wiederhold, A.R. Stacey, Andrew Alexander Knox, S. Malla, K.L. Lowe, C.H. Coles, Z. Donnellan, Samantha Paston, Joseph Dukes, Bent K. Jakobsen, R.A. Robinson, M. Aleksic, A. Walker, Michelle L. McCully
Publikováno v:
The Journal of Immunology. 204:1943-1953
The molecular rules driving TCR cross-reactivity are poorly understood and, consequently, it is unclear the extent to which TCRs targeting the same Ag recognize the same off-target peptides. We determined TCR–peptide–HLA crystal structures and, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b03e627be240f30ea60a4a4dabb09d
https://doi.org/10.4049/jimmunol.1900915
https://doi.org/10.4049/jimmunol.1900915
Autor:
Joseph J. Sacco, Richard D. Carvajal, Marcus O. Butler, Alexander N. Shoushtari, Jessica C. Hassel, Alexandra Ikeguchi, Leonel Hernandez-Aya, Paul Nathan, Omid Hamid, Josep M. Piulats, Matthew Rioth, Douglas B. Johnson, Jason J. Luke, Erique Espinosa, Serge Leyvraz, Laura Collins, Chris Holland, Michelle L. McCully, Takami Sato
Publikováno v:
Cancer Research. 83:CT223-CT223
Background: Tebentafusp, a bispecific (gp100 x CD3) ImmTAC, is approved for adult HLA-A*02:01+ patients with unresectable or metastatic uveal melanoma (mUM). In the Ph2 IMCgp100-102 study of pts with previously treated mUM (NCT02570308), tebentafusp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ec3a1d74c73e0a5cd71666f299dc049
https://doi.org/10.1158/1538-7445.am2023-ct223
https://doi.org/10.1158/1538-7445.am2023-ct223
Autor:
Bernhard eMoser, Michelle L. McCully
Publikováno v:
Frontiers in Immunology, Vol 2 (2011)
Irrespective of the immune status, the vast majority of all lymphocytes reside in peripheral tissues whereas those present in blood only amount to a small fraction of the total. It has been estimated that T cells in healthy human skin outnumber those
Externí odkaz:
https://doaj.org/article/f8e242ae021e4bbd9821999cd6315b4a
Autor:
Richard D. Carvajal, Douglas B. Johnson, Alexander N. Shoushtari, Jason J. Luke, Joseph J. Sacco, Omid Hamid, Josep M. Piulats, Shaad Essa Abdullah, Enrique Espinosa, Michelle L. McCully, Marcus W. Butler, Leonel Hernandez-Aya, Jessica C. Hassel, Christopher J. Holland, Serge Leyvraz, Alexandra Ikeguchi, Paul C. Nathan, Matthew J. Rioth, Takami Sato
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundTebentafusp, a bispecific fusion protein consisting of an affinity-enhanced T cell receptor fused to an anti-CD3 effector that can redirect T cells to target gp100+ cells, has shown an overall survival benefit for patients with untreated me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6660859e85b4fa409fe29b51a111e527
https://doi.org/10.1136/jitc-2021-sitc2021.538
https://doi.org/10.1136/jitc-2021-sitc2021.538
Autor:
Josep M. Piulats, Alexandra Ikeguchi, Omid Hamid, Richard D. Carvajal, Jessica C. Hassel, Takami Sato, Laura C. Collins, Shaad Essa Abdullah, Serge Leyvraz, Jason J. Luke, Joseph J. Sacco, Alexander N. Shoushtari, Michelle L. McCully, Douglas B. Johnson, Marcus O. Butler, Enrique Espinosa, Leonel Hernandez-Aya, Sarah Lockwood, Paul C. Nathan, Matthew J. Rioth
Publikováno v:
Journal of Clinical Oncology. 39:9531-9531
9531 Background: Cytokine-mediated adverse events (AEs) are commonly reported in pts treated with T cell engaging therapies. Tebentafusp (tebe), a bispecific consisting of an affinity-enhanced T cell receptor fused to an anti-CD3 effector that can re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99efa4e325238ed1198c9b475f1bd61d
https://doi.org/10.1200/jco.2021.39.15_suppl.9531
https://doi.org/10.1200/jco.2021.39.15_suppl.9531
Cellular immunity is governed by a complex network of migratory cues that enable appropriate immune cell responses in a timely and spatially controlled fashion. This review focuses on the chemokines and their receptors regulating the steady-state loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8192841390b55559aa7251c4bf5cbc3a
Autor:
Paul J, Collins, Michelle L, McCully, Laura, Martínez-Muñoz, César, Santiago, James, Wheeldon, Stephan, Caucheteux, Sylvia, Thelen, Valentina, Cecchinato, Julia M, Laufer, Vladimir, Purvanov, Yoan R, Monneau, Hugues, Lortat-Jacob, Daniel F, Legler, Mariagrazia, Uguccioni, Marcus, Thelen, Vincent, Piguet, Mario, Mellado, Bernhard, Moser
Publikováno v:
The FASEB Journal
The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expressed in blood and tissue cells, and is essential during embryogenesis and hematopoiesis. CXCL14 is a homeostatic chemokine wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4cec29ba72318621685bc785cfc779b2
https://pubmed.ncbi.nlm.nih.gov/28360196
https://pubmed.ncbi.nlm.nih.gov/28360196