Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Michelle L Kirtley"'
Autor:
Tatiana E Erova, Michelle L Kirtley, Erc C Fitts, Duraisamy Ponnusamy, Wallace B Baze, Jourdan A Andersson, Yingzi Cong, Bethany L Tiner, Jian Sha, Ashok K Chopra
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 6 (2016)
We evaluated the extent of attenuation and immunogenicity of the ∆lppAB and ∆lppAB ∆msbB mutants of Salmonella enterica serovar Typhimurium when delivered to mice by the oral route. These mutants were deleted either for the Braun lipoprotein ge
Externí odkaz:
https://doaj.org/article/d8a91f8e569d44269027cadadf724fb6
Autor:
Pan Tao, Marthandan Mahalingam, Michelle L Kirtley, Christina J van Lier, Jian Sha, Linsey A Yeager, Ashok K Chopra, Venigalla B Rao
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003495 (2013)
Pneumonic plague is a highly virulent infectious disease with 100% mortality rate, and its causative organism Yersinia pestis poses a serious threat for deliberate use as a bioterror agent. Currently, there is no FDA approved vaccine against plague.
Externí odkaz:
https://doaj.org/article/538904e27fdb40aa8d1a5057c496d528
Autor:
Amanda R. Haltom, Wafa E. Hassen, Janine Hensel, Jiha Kim, Hikaru Sugimoto, Bingrui Li, Kathleen M. McAndrews, Meagan R. Conner, Michelle L. Kirtley, Xin Luo, Bingqing Xie, Olga V. Volpert, Susan Olalekan, Natalia Maltsev, Anindita Basu, Valerie S. LeBleu, Raghu Kalluri
Publikováno v:
Extracellular Vesicle, Vol 1, Iss , Pp 100014- (2022)
Dysregulated Myc signaling is a key oncogenic pathway in glioblastoma multiforme (GBM). Yet, effective therapeutic targeting of Myc continues to be challenging. Here, we demonstrate that exosomes generated from human bone marrow mesenchymal stem cell
Externí odkaz:
https://doaj.org/article/31ae9f76978c40408bc4b64bc343197a
Autor:
Raghu Kalluri, Valerie S. LeBleu, Hikaru Sugimoto, Chia-Chin Wu, Mariangela Natale, Michelle L. Kirtley, Pedro Correa de Sampaio, Toru Miyake, Huamin Wang, Bingrui Li, Julienne L. Carstens, Sujuan Yang, Xiaofeng Zheng, J. Kebbeh Darpolor, Yang Chen, Kathleen M. McAndrews
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a significant accumulation of fibroblasts as part of the host response to cancer. Using single-cell RNA sequencing, multiplex immunostaining, and several genetic mouse mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78390c98982b7462c1b3f63210342837
https://doi.org/10.1158/2159-8290.c.6549515
https://doi.org/10.1158/2159-8290.c.6549515
Autor:
Raghu Kalluri, Valerie S. LeBleu, Hikaru Sugimoto, Chia-Chin Wu, Mariangela Natale, Michelle L. Kirtley, Pedro Correa de Sampaio, Toru Miyake, Huamin Wang, Bingrui Li, Julienne L. Carstens, Sujuan Yang, Xiaofeng Zheng, J. Kebbeh Darpolor, Yang Chen, Kathleen M. McAndrews
Supplementary Data from Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8a7ecd0ab3f2ea2cf1abfbd222e5b7
https://doi.org/10.1158/2159-8290.22540934
https://doi.org/10.1158/2159-8290.22540934
Autor:
Krishnan K. Mahadevan, Kathleen M. McAndrews, Valerie S. LeBleu, Sujuan Yang, Hengyu Lyu, Bingrui Li, Amari M. Sockwell, Michelle L. Kirtley, Sami J. Morse, Barbara A. Moreno Diaz, Michael P. Kim, Ningping Feng, Anastasia M. Lopez, Paola A. Guerrero, Hikaru Sugimoto, Kent A. Arian, Haoqiang Ying, Yasaman Barekatain, Patience J. Kelly, Anirban Maitra, Timothy P. Heffernan, Raghu Kalluri
Publikováno v:
bioRxiv
Pancreatic ductal adenocarcinoma (PDAC) is associated with mutations in Kras, a known oncogenic driver of PDAC; and theKRASG12Dmutation is present in nearly half of PDAC patients. Recently, a non-covalent small molecule inhibitor (MRTX1133) was ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ea79611c3fdc6d33522b958197d67c
https://doi.org/10.1101/2023.02.15.528757
https://doi.org/10.1101/2023.02.15.528757
Autor:
Raghu Kalluri, Bingrui Li, Hikaru Sugimoto, Changsoo Kwak, Karina Vázquez-Arreguín, Valerie S. LeBleu, Michelle L. Kirtley, Xiaofeng Zheng, Kathleen M. McAndrews
Publikováno v:
Oncogene
The development and progression of solid tumors is dependent on cancer cell autonomous drivers and the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) in the TME possess both tumor-promoting and tumor-restraining functions. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d597c4ff00d0b6bb43cf267f8f25f5cc
https://doi.org/10.1038/s41388-021-01866-7
https://doi.org/10.1038/s41388-021-01866-7
Autor:
Eric C. Fitts, Jourdan A. Andersson, Michelle L. Kirtley, Jian Sha, Tatiana E. Erova, Sadhana Chauhan, Vladimir L. Motin, Ashok K. Chopra
Publikováno v:
mSphere, Vol 1, Iss 6 (2016)
ABSTRACT The Enterobacteriaceae family members, including the infamous Yersinia pestis, the causative agent of plague, have a highly conserved interbacterial signaling system that is mediated by the autoinducer-2 (AI-2) quorum-sensing molecule. The A
Externí odkaz:
https://doaj.org/article/f5e9bf8105cc43fc899d565a281323ec
Autor:
Christopher J. Grim, Elena V. Kozlova, Jian Sha, Eric C. Fitts, Christina J. van Lier, Michelle L. Kirtley, Sandeep J. Joseph, Timothy D. Read, Eileen M. Burd, Ben D. Tall, Sam W. Joseph, Amy J. Horneman, Ashok K. Chopra, Joshua R. Shak
Publikováno v:
mBio, Vol 4, Iss 2 (2013)
ABSTRACT Aeromonas hydrophila has increasingly been implicated as a virulent and antibiotic-resistant etiologic agent in various human diseases. In a previously published case report, we described a subject with a polymicrobial wound infection that i
Externí odkaz:
https://doaj.org/article/f406938062cc4187a456691fb4083c86
Autor:
Kathleen M. McAndrews, Yang Chen, J. Kebbeh Darpolor, Xiaofeng Zheng, Sujuan Yang, Julienne L. Carstens, Bingrui Li, Huamin Wang, Toru Miyake, Pedro Correa de Sampaio, Michelle L. Kirtley, Mariangela Natale, Chia-Chin Wu, Hikaru Sugimoto, Valerie S. LeBleu, Raghu Kalluri
Publikováno v:
Cancer Discov
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a significant accumulation of fibroblasts as part of the host response to cancer. Using single-cell RNA sequencing, multiplex immunostaining, and several genetic mouse mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b52929a3c51daeda12781040add60d
https://pubmed.ncbi.nlm.nih.gov/35348629
https://pubmed.ncbi.nlm.nih.gov/35348629