Ribosomal DNA copy number is associated with body mass in humans and other mammals

Autor: Pui Pik Law, Liudmila A. Mikheeva, Francisco Rodriguez-Algarra, Fredrika Asenius, Maria Gregori, Robert A. E. Seaborne, Selin Yildizoglu, James R. C. Miller, Hemanth Tummala, Robin Mesnage, Michael N. Antoniou, Weilong Li, Qihua Tan, Sara L. Hillman, Vardhman K. Rakyan, David J. Williams, Michelle L. Holland

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Body mass results from a complex interplay between genetics and environment. Previous studies of the genetic contribution to body mass have excluded repetitive regions due to the technical limitations of platforms used for population scale s

Externí odkaz: https://doaj.org/article/80eab87c54514fd3a8296ed1fbbcc98c

The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations.

Autor: Fredrika Åsenius, Tyler J Gorrie-Stone, Ama Brew, Yasmin Panchbhaya, Elizabeth Williamson, Leonard C Schalkwyk, Vardhman K Rakyan, Michelle L Holland, Sarah J Marzi, David J Williams

Publikováno v: PLoS Genetics, Vol 16, Iss 10, p e1009035 (2020)

Epidemiological research suggests that paternal obesity may increase the risk of fathering small for gestational age offspring. Studies in non-human mammals indicate that such associations could be mediated by DNA methylation changes in spermatozoa t

Externí odkaz: https://doaj.org/article/4e7639db547f4dac8a0fb9dbae7c93a9

A stochastic basis for metabolic phenotypes

Autor: Michelle L, Holland, Vardhman K, Rakyan

Publikováno v: Nature metabolism. 4(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26a98659637e248b7546e313c0070eb9
https://pubmed.ncbi.nlm.nih.gov/36097183

Deciphering the Role of the Non-Coding Genome in Regulating Gene-Diet Interactions

Autor: Pui-Pik Law, Michelle L. Holland

Publikováno v: Nutrients, Vol 10, Iss 12, p 1831 (2018)

Protein encoding genes constitute a small fraction of mammalian genomes. In addition to the protein coding genes, there are other functional units within the genome that are transcribed, but not translated into protein, the so called non-coding RNAs.

Externí odkaz: https://doaj.org/article/f486c808f84247e3be838a715040cb2c

Identification of the transcription factor MAZ as a regulator of erythropoiesis

Autor: Darya Deen, Jan Frayne, Matthias Mann, Daniel C. J. Ferguson, Helena Ayyub, Vasiliki Samara, Michelle L. Holland, Falk Butter, Jacqueline A. Sloane-Stanley, Douglas Vernimmen, Ivan Ferrer-Vicens, David Garrick, Deborah E. Daniels

Publikováno v: Deen, D, Butter, F, Daniels, D, Ferrer-Vicens, I, Vernimmen, D, Garrick, D, Holland, M L, Samara, V, Sloane-Stanley, J A, Ayyub, H, Mann, M, Frayne, J & Ferguson, D 2021, ' Identification of the transcription factor MAZ as a regulator of erythropoiesis ', Blood Advances, pp. 3002-3015 . https://doi.org/10.1182/bloodadvances.2021004609
Deen, D, Daniels, D E, Ferrer-Vicens, I, Ferguson, D C J, Frayne, J, Vernimmen, D & al., E 2021, ' Identification of the transcription factor MAZ as a regulator of erythropoiesis ', Blood Advances, vol. 5, no. 15, pp. 3002-3015 . https://doi.org/10.1182/bloodadvances.2021004609

Erythropoiesis requires a combination of ubiquitous and tissue-specific transcription factors (TFs). Here, through DNA affinity purification followed by mass spectrometry, we have identified the widely expressed protein MAZ (Myc-associated zinc finge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1803f22fa6b8a0383e0dd594d4ce65
https://pubmed.ncbi.nlm.nih.gov/35298619