Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michelle L Bland"'
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001438 (2021)
[This corrects the article DOI: 10.1371/journal.pbio.3000721.].
Externí odkaz:
https://doaj.org/article/e1cad5ee398e4fd6b57fbf018a4479e3
Autor:
Brittany A Martínez, Rosalie G Hoyle, Scott Yeudall, Mitchell E Granade, Thurl E Harris, J David Castle, Norbert Leitinger, Michelle L Bland
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009192 (2020)
During infection, cellular resources are allocated toward the metabolically-demanding processes of synthesizing and secreting effector proteins that neutralize and kill invading pathogens. In Drosophila, these effectors are antimicrobial peptides (AM
Externí odkaz:
https://doaj.org/article/68fbace5dc1f44709095beda0b986904
Publikováno v:
PLoS Biology, Vol 18, Iss 5, p e3000721 (2020)
Dietary nutrients provide macromolecules necessary for organism growth and development. In response to animal feeding, evolutionarily conserved growth signaling pathways are activated, leading to increased rates of cell proliferation and tissue growt
Externí odkaz:
https://doaj.org/article/9dbeef7ff36d4f9183cf2ab677ad9726
Autor:
Michelle L, Bland
Publikováno v:
Seminars in Cell & Developmental Biology. 138:128-141
Infection with pathogenic microbes is a severe threat that hosts manage by activating the innate immune response. In Drosophila melanogaster, the Toll and Imd signaling pathways are activated by pathogen-associated molecular patterns to initiate cell
Autor:
Katharina Bottermann, Axel Gödecke, Katelyn W. Ahern, Jae Woo Kim, Susanna R. Keller, Vici Oenarto, Mitchell E. Granade, Smanla Tundup, Thurl E. Harris, Vidisha Raje, Alexandra Kadl, Michelle L. Bland, Nancy L. Howell, Brittany A. Martinez
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Stress hyperglycemia and insulin resistance are evolutionarily conserved metabolic adaptations to severe injury including major trauma, burns, or hemorrhagic shock (HS). In response to injury, the neuroendocrine system increases secretion of counterr
Publikováno v:
PLoS Biology, Vol 18, Iss 5, p e3000721 (2020)
PLoS Biology
PLoS Biology
Dietary nutrients provide macromolecules necessary for organism growth and development. In response to animal feeding, evolutionarily conserved growth signaling pathways are activated, leading to increased rates of cell proliferation and tissue growt
Publikováno v:
Cell reports
Cell Reports, Vol 22, Iss 10, Pp 2550-2556 (2018)
Cell Reports, Vol 22, Iss 10, Pp 2550-2556 (2018)
SUMMARY In obese adipose tissue, Toll-like receptor signaling in macrophages leads to insulin resistance in adipocytes. Similarly, Toll signaling in the Drosophila larval fat body blocks insulin-dependent growth and nutrient storage. We find that Tol
Autor:
Mitchell E. Granade, Thurl E. Harris, Rosalie G. Hoyle, Brittany A. Martinez, Michelle L. Bland, J. David Castle, Scott Yeudall, Norbert Leitinger
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 11, p e1009192 (2020)
PLoS Genetics, Vol 16, Iss 11, p e1009192 (2020)
During infection, cellular resources are allocated toward the metabolically-demanding processes of synthesizing and secreting effector proteins that neutralize and kill invading pathogens. In Drosophila, these effectors are antimicrobial peptides (AM
Publikováno v:
Cell Reports. 28:1439-1446.e5
Summary Chronic enteropathogen infection in early childhood reduces circulating insulin-like growth factor 1 (IGF1) levels and restricts growth. Pathogen-derived molecules activate host Toll-like receptors to initiate the immune response, but whether
Autor:
Michelle L. Bland
Publikováno v:
Journal of Visualized Experiments.
The power of Drosophila genetics is increasingly being applied to questions of hormone signaling and metabolism and to the development of models of human disease in this organism. Sensitive methods for measurements of parameters such as metabolic rat