Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michelle Kurpakus-Wheater"'
Publikováno v:
The FASEB Journal. 25:1815-1826
The mechanisms by which thymosin β 4 (Tβ4) regulates the inflammatory response to injury are poorly understood. Previously, we demonstrated that ectopic Tβ4 treatment inhibits injury-induced proinflammatory cytokine and chemokine production. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51971794e97b09aafa45ca5bee6e3eb3
https://doi.org/10.1096/fj.10-167940
https://doi.org/10.1096/fj.10-167940
Publikováno v:
Annals of the New York Academy of Sciences. 1194:190-198
Persistent corneal epithelial defects and inflammation within the central cornea can directly distort visual acuity and may lead to permanent visual loss. Therefore, treatments with agents that enhance corneal reepithelialization and regulate the inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f3ef303c3814ac5e6b349dd4887109d
https://doi.org/10.1111/j.1749-6632.2010.05472.x
https://doi.org/10.1111/j.1749-6632.2010.05472.x
Publikováno v:
Annals of the New York Academy of Sciences. 1112:114-122
The cornea epithelium responds to injury by synthesizing several cytokines, growth factors, and tissue remodeling molecules. Proinflammatory cytokines have been implicated in the inflammation that follows corneal epithelial injury and cytokine-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746cee6f6e1a32e49df2242ac827be2a
https://doi.org/10.1196/annals.1415.004
https://doi.org/10.1196/annals.1415.004
Publikováno v:
Experimental Eye Research. 84:663-669
The purpose of this study was to determine the effect of thymosin beta 4 (Tbeta4) on NFkappaB protein levels, activation, phosphorylation, and nuclear translocation in a model of tumor necrosis factor (TNF)-alpha-mediated corneal inflammation. Transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db273d131e141ec91c0429e21e66f43b
https://doi.org/10.1016/j.exer.2006.12.004
https://doi.org/10.1016/j.exer.2006.12.004
Autor:
David Ellenberg, Atif Siddiqi, Gabriel Sosne, Brian Hollis, Michelle Kurpakus-Wheater, Abdul Rahman Albeiruti
Publikováno v:
Experimental Eye Research. 83:502-507
Thymosin beta-4 (Tbeta(4)) is known to promote ocular wound healing, to decrease ocular inflammation, and to have anti-apoptotic effects on corneal epithelium. In this study, the effect of Tbeta(4) on the survival of human ocular surface epithelial c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adbb439e4a639a30c331ef21b95160b
https://doi.org/10.1016/j.exer.2006.02.001
https://doi.org/10.1016/j.exer.2006.02.001
Publikováno v:
Experimental Eye Research. 80:1-8
In addition to its role as an inhibitor of urokinase plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1) is hypothesized to regulate epithelial cell adhesion and migration. We have previously reported that PAI-1 may be an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52e13afc249ba1e04a5eb313c3f425b
https://doi.org/10.1016/j.exer.2004.06.006
https://doi.org/10.1016/j.exer.2004.06.006
Autor:
Michelle Kurpakus-Wheater, Zhiyu Wang
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 35:339-348
The aim of this study was to determine the effects of hypoxia on mRNA levels, cell-associated and -secreted protein concentration, activity, and protein complex formation of urokinase-type plasminogen activator, its receptor, and plasminogen activato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6f83f22f11dcf27622af376f2eeabd
https://doi.org/10.1016/s1357-2725(02)00254-6
https://doi.org/10.1016/s1357-2725(02)00254-6
Publikováno v:
Journal of Cell Science. 114:4033-4040
Laminin 5 functions to promote cell-matrix adhesion and therefore is hypothesized to abrogate apoptosis initiated through the loss of epithelial cell contact with extracellular matrix. Laminin 5 levels are decreased in epithelial cells cultured in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4bf54713a837ffba48e4f59fc4c0be
https://doi.org/10.1242/jcs.114.22.4033
https://doi.org/10.1242/jcs.114.22.4033
Publikováno v:
Progress in Histochemistry and Cytochemistry. 36:179-259
The anterior surface of the eye is composed of the cornea, conjunctiva, and the zonebetween the two called the limbus. The cornea must maintain optical clarity to retain good vision. However, the ocular surface is vulnerable to trauma, microbial infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e75319473d1684b707255ddc8d15e4cb
https://doi.org/10.1016/s0079-6336(01)80003-6
https://doi.org/10.1016/s0079-6336(01)80003-6
Publikováno v:
Experimental Eye Research. 70:537-546
Both the laminin composition of the basement membrane and the keratin intermediate filament composition of the epithelial cell differs between cornea and conjunctiva, suggesting that at least some aspects of ocular surface epithelial cell differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc90a6cd89462bc24e5aa0b5b24e247
https://doi.org/10.1006/exer.1999.0811
https://doi.org/10.1006/exer.1999.0811