Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michelle Kraus"'
Autor:
Luping Qiu, Kymberly Levine, Ketan S Gajiwala, Ciarán N Cronin, Asako Nagata, Eric Johnson, Michelle Kraus, John Tatlock, Robert Kania, Timothy Foley, Shaoxian Sun
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198374 (2018)
Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as an oncogene that promotes tumor cell proliferation, migration and evasion. Both kinase-dependent and -independent functions of PTK6 in driving tumor g
Externí odkaz:
https://doaj.org/article/14826eba87d1454caa8322f0b783ae9f
Autor:
Michelle Tran-Dubé, Bruce M. Bechle, Michelle Kraus, Ciarán N. Cronin, Kim James, Joseph S. Warmus, Fen Wang, Jianmin Sun, Indrawan James Mcalpine, Sacha Ninkovic, Jianwei Bian, Samantha Elizabeth Greasley, Neil J. Flanagan, Matthew Corbett, Rebecca Dias, Andrews Mark David, Asako Nagata, John F. Braganza, Linda Kitching, David C. Blakemore, Eric Johnson, Sarah Elizabeth Skerratt, Kiyoyuki Omoto, Sharan K. Bagal, Jingrong Jean Cui, James Bilsland, Peter J. Bungay, Rachel L. Grimley, Stephanie Scales, Gareth Waldron
Publikováno v:
Journal of medicinal chemistry. 61(15)
Hormones of the neurotrophin family, nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), are known to activate the family of Tropomyosin receptor kinases (TrkA, TrkB, and TrkC). Moreove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f470c72f1e1c68f507f99de2c39e1f77
https://pubmed.ncbi.nlm.nih.gov/29944371
https://pubmed.ncbi.nlm.nih.gov/29944371
Autor:
Robert Steven Kania, Eric Johnson, Tatlock John H, Luping Qiu, Timothy L. Foley, Shaoxian Sun, Kymberly Levine, Ketan S. Gajiwala, Ciarán N. Cronin, Michelle Kraus, Asako Nagata
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0198374 (2018)
PLoS ONE, Vol 13, Iss 6, p e0198374 (2018)
Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as an oncogene that promotes tumor cell proliferation, migration and evasion. Both kinase-dependent and -independent functions of PTK6 in driving tumor g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed360b0109ea048c220a42f22b9203e
http://europepmc.org/articles/PMC5991704
http://europepmc.org/articles/PMC5991704
Autor:
Michelle Kraus, Jay M. Wendling, Olga V. Nemirovskiy, John W. Rains, Vincent Peterkin, Laura E. Zawadzke, Hideji Fujiwara, Ciarán N. Cronin, Troii Hall, Tom Kasten, Maureen K. Highkin, Gina M. Jerome, Arthur J. Wittwer, Matthew P. Yates, Shinji Ogawa, Jeffrey A. Scholten, Jill Chrencik, Marek M. Nagiec, Matthew D. McReynolds, Kaliapan Iyanar, Mark E. Schnute, Kristin Cukyne, Matthew J. Saabye, Richard M. Broadus
Publikováno v:
Biochemical Journal. 444:79-88
SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c29039f87435103ee01d57e1663842f
https://doi.org/10.1042/bj20111929
https://doi.org/10.1042/bj20111929
Autor:
Michelle Kraus, Stephan Grant, Sutton Scott Channing, Ciarán N. Cronin, Alexandra Hofler, John Charles Kath, Scott Gridley, Mike Gehring, Timothy Nichols, Edward A. Esposito, Gordon Alton, Jacques Ermolieff, Laura Lingardo, Murphy Sean T, Zhi Xie
Publikováno v:
Analytical Biochemistry. 414:179-186
The PI3K/AKT signaling pathway has an important regulatory role in cancer cell growth and tumorigenesis. Signal transduction through this pathway requires the assembly and activation of PDK1 and AKT at the plasma membrane. On activation of the pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafb0ace08d77461f8968b1004b4ec48
https://doi.org/10.1016/j.ab.2011.03.013
https://doi.org/10.1016/j.ab.2011.03.013
Autor:
Murphy Sean T, Gordon Alton, Xiao-Hong Yu, Stan Kupchinsky, Steven P. Tanis, Jacques Ermolieff, Tran Khanh Tuan, Min-Jean Yin, Sangita M. Baxi, William F. Vernier, Natasha M. Kablaoui, Michael J. Hickey, Benjamin J. Burke, John Charles Kath, Zhi Xie, Daniel Tyler Richter, John M. Humphrey, Michelle Kraus, RoseAnn Ferre, John Li, Matthew A. Marx, Thomas Allen Chappie, Samantha Elizabeth Greasley, Steven Kazmirski, Simon Bailey, Laura Lingardo
Publikováno v:
Journal of medicinal chemistry. 54(24)
Analogues substituted with various amines at the 6-position of the pyrazine ring on (4-amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyrazin-2-ylmethanone were discovered as potent and selective inhibitors of PDK1 with potential as anticancer age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101b59a087b116c191559a0cc406942f
https://pubmed.ncbi.nlm.nih.gov/22040023
https://pubmed.ncbi.nlm.nih.gov/22040023
Autor:
Sean T. Murphy, Gordon Alton, Simon Bailey, Sangita M. Baxi, Benjamin J. Burke, Thomas A. Chappie, Jacques Ermolieff, RoseAnn Ferre, Samantha Greasley, Michael Hickey, John Humphrey, Natasha Kablaoui, John Kath, Steven Kazmirski, Michelle Kraus, Stan Kupchinsky, John Li, Laura Lingardo, Matthew A. Marx, Dan Richter
Publikováno v:
Journal of Medicinal Chemistry; Dec2011, Vol. 54 Issue 24, p8490-8500, 11p