Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michelle Kokkinou"'
Autor:
Chiara Prodani, Elaine E. Irvine, Alessandro Sardini, Hannah J. Gleneadie, Andrew Dimond, Mathew Van de Pette, Rosalind John, Michelle Kokkinou, Oliver Howes, Dominic J. Withers, Mark A. Ungless, Matthias Merkenschlager, Amanda G. Fisher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract We tracked the consequences of in utero protein restriction in mice throughout their development and life course using a luciferase-based allelic reporter of imprinted Cdkn1c. Exposure to gestational low-protein diet (LPD) results in the ina
Externí odkaz:
https://doaj.org/article/81d158cc89d44bcea82892374ccb7f0f
Autor:
Els F. Halff, Sridhar Natesan, David R. Bonsall, Mattia Veronese, Anna Garcia-Hidalgo, Michelle Kokkinou, Sac-Pham Tang, Laura J. Riggall, Roger N. Gunn, Elaine E. Irvine, Dominic J. Withers, Lisa A. Wells, Oliver D. Howes
Publikováno v:
Molecular Imaging, Vol 2022 (2022)
Positron emission tomography (PET) using the radiotracer [18F]-FDOPA provides a tool for studying brain dopamine synthesis capacity in animals and humans. We have previously standardised a micro-PET methodology in mice by intravenously administering
Externí odkaz:
https://doaj.org/article/f768fa347d054483bb676f5799b52e6f
Autor:
Michelle Kokkinou, Sridhar Natesan, Kyoko Tossell, Seth C. Hopkins, David R. Bonsall, Dominic J. Withers, Mark A. Ungless, Eleanor J. Paul, Nina Dedic, Mark A. Smith, Elaine E. Irvine, Justyna A. Glegola, Oliver D. Howes, Lisa Wells, Sanjay Khadayate, Mattia Veronese
Publikováno v:
Molecular Psychiatry
Howes, O, Kokkinou, M, Natesan, S, Irving, E, Bonsall, D R, Wells, L A, Smith, M, Glegola, J, Paul, E, Tossell, K, Veronese, M, Khadayate, S, Dedic, N, Hopkins, S, Ungless, M A & Withers, D J 2020, ' Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it : a translational imaging study with ketamine ', Molecular Psychiatry, vol. 0, no. 0, pp. 1-15 . https://doi.org/10.1038/s41380-020-0740-6
Howes, O, Kokkinou, M, Natesan, S, Irving, E, Bonsall, D R, Wells, L A, Smith, M, Glegola, J, Paul, E, Tossell, K, Veronese, M, Khadayate, S, Dedic, N, Hopkins, S, Ungless, M A & Withers, D J 2020, ' Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it : a translational imaging study with ketamine ', Molecular Psychiatry, vol. 0, no. 0, pp. 1-15 . https://doi.org/10.1038/s41380-020-0740-6
Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdda13867bfbd9b976fa45cddd77d3b
http://europepmc.org/articles/PMC8440182
http://europepmc.org/articles/PMC8440182
Autor:
Tiziana Casoli, Obioha C Ukoumunne, Chris Hyde, Meera Desai, Aikaterini Georgopoulou, Eleanor J. Paul, Abhishekh Hulegar Ashok, Terry J Quinn, Rosemary Worrall, Anja Hayen, Nadja Smailagic, Anna H Noel-Storr, Craig W. Ritchie, Michelle Kokkinou, Lucy Beishon
Publikováno v:
The Cochrane Library
Kokkinou, M, Beishon, L C, Smailagic, N, Noel-storr, A H, Hyde, C, Ukoumunne, O, Worrall, R E, Hayen, A, Desai, M, Ashok, A H, Paul, E J, Georgopoulou, A, Casoli, T, Quinn, T J & Ritchie, C W 2021, ' Plasma and cerebrospinal fluid ABeta42 for the differential diagnosis of Alzheimer's disease dementia in participants diagnosed with any dementia subtype in a specialist care setting ', Cochrane Library . https://doi.org/10.1002/14651858.CD010945.pub2
Cochrane Database Syst Rev
Kokkinou, M, Beishon, L C, Smailagic, N, Noel-storr, A H, Hyde, C, Ukoumunne, O, Worrall, R E, Hayen, A, Desai, M, Ashok, A H, Paul, E J, Georgopoulou, A, Casoli, T, Quinn, T J & Ritchie, C W 2021, ' Plasma and cerebrospinal fluid ABeta42 for the differential diagnosis of Alzheimer's disease dementia in participants diagnosed with any dementia subtype in a specialist care setting ', Cochrane Library . https://doi.org/10.1002/14651858.CD010945.pub2
Cochrane Database Syst Rev
Background Dementia is a syndrome that comprises many differing pathologies, including Alzheimer's disease dementia (ADD), vascular dementia (VaD) and frontotemporal dementia (FTD). People may benefit from knowing the type of dementia they live with,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a99196a7682b65bf33c70a2f20e01ac
https://doi.org/10.1002/14651858.cd010945.pub2
https://doi.org/10.1002/14651858.cd010945.pub2
Publikováno v:
Biological psychiatry. Cognitive neuroscience and neuroimaging. 6(6)
Converging lines of evidence from epidemiological, preclinical, and experimental studies indicate that the endocannabinoid system may be involved in the pathophysiology of schizophrenia and suggest that the cannabinoid CB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99df7da9f0a53d86c45e48facc55bad3
https://pubmed.ncbi.nlm.nih.gov/33077399
https://pubmed.ncbi.nlm.nih.gov/33077399
Autor:
Nina Dedic, Mark A. Ungless, Mattia Veronese, Oliver D. Howes, Sanjay Khadayate, Seth C. Hopkins, Eleanor J. Paul, David R. Bonsall, Kyoko Tossell, Dominic J. Withers, Justyna A. Glegola, Sridhar Natesan, Lisa Wells, Elaine E. Irvine, Mark Smith, Michelle Kokkinou
Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. However, the mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV) neuronal d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acd1787cf4257cef5540a828d54f499
https://doi.org/10.1101/748665
https://doi.org/10.1101/748665
Autor:
Michelle Kokkinou, Oliver D. Howes
BACKGROUND: Ketamine, an N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, induces psychotic-like effects in healthy human and exacerbates symptoms in patients with schizophrenia (Krystal et al., 1994, Lahti et al., 1991). Therefore, ketamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e29a57f384f32d311968686bdfbe25
https://europepmc.org/articles/PMC6455725/
https://europepmc.org/articles/PMC6455725/
Autor:
Michelle Kokkinou, Nadja Smailagic, Anna H Noel-Storr, Chris Hyde, Obioha Ukoumunne, Rosie E Worrall, Anja Hayen, Meera Desai, Craig Ritchie
© 2014 The Cochrane Collaboration. This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the diagnostic accuracy of the plasma and CSF Abeta42 index tests for distinguishing Alzheimer's disease demen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d116d0d8895ce5a1c2d2499587bd5b74
Autor:
Eleanor Sandhu, Elaine E. Irvine, Anushka B. P. Fernando, Oliver D. Howes, Kyoko Tossell, Mark A. Ungless, Dominic J. Withers, Justyna A. Glegola, Mark A. Smith, Michelle Kokkinou
Publikováno v:
eNeuro
Salt intake is an essential dietary requirement, but excessive consumption is implicated in hypertension and associated conditions. Little is known about the neural circuit mechanisms that control motivation to consume salt, although the midbrain dop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5dbf9a9160c9eeefdb34d432d32cbc
http://europepmc.org/articles/PMC5952649
http://europepmc.org/articles/PMC5952649
Autor:
Oliver D. Howes, Michelle Kokkinou, Lisa Wells, Christopher Coello, David R. Bonsall, Mattia Veronese
Cocaine is a recreational drug of abuse that binds to the dopamine transporter (DAT), preventing reuptake of dopamine into presynaptic terminals. The increased presence of synaptic dopamine results in stimulation of both pre- and postsynaptic dopamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bff6247c4d648217a070dabd9f0bef
http://hdl.handle.net/10044/1/51220
http://hdl.handle.net/10044/1/51220