Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Michelle Kelleher"'
Autor:
Marisa Zallocchi, Katie Binley, Yatish Lad, Scott Ellis, Peter Widdowson, Sharifah Iqball, Vicky Scripps, Michelle Kelleher, Julie Loader, James Miskin, You-Wei Peng, Wei-Min Wang, Linda Cheung, Duane Delimont, Kyriacos A Mitrophanous, Dominic Cosgrove
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94272 (2014)
Usher syndrome type 1B is a combined deaf-blindness condition caused by mutations in the MYO7A gene. Loss of functional myosin VIIa in the retinal pigment epithelia (RPE) and/or photoreceptors leads to blindness. We evaluated the impact of subretinal
Externí odkaz:
https://doaj.org/article/15299d8f6d1046bd8a87be0928d96b1d
Autor:
Julie Loader, Michelle Kelleher, Kyriacos A. Mitrophanous, Vicky Kennedy, Laura McCloskey, Maria Parker, Naghmeh Fouladi, Scott Ellis, Katie Binley, J. Timothy Stout
Publikováno v:
Human Gene Therapy. 29:687-698
Due to both the avascularity of the cornea and the relatively immune-privileged status of the eye, corneal transplantation is one of the most successful clinical transplant procedures. However, in high-risk patients, which account for >20% of the 180
Autor:
Tahreem A. Mir, Peter A. Campochiaro, Elliott H. Sohn, Andreas K. Lauer, Michelle Kelleher, Stuart Naylor, Kyriacos A. Mitrophanous, Scott Ellis, Matthew C. Anderton, Richard Harrop
Publikováno v:
Human Gene Therapy. 28:99-111
Neovascular age-related macular degeneration (NVAMD) is a prevalent cause of vision loss. Intraocular injections of VEGF-neutralizing proteins provide benefit, but many patients require frequent injections for a prolonged period. Benefits are often l
Autor:
Jeanne Gourlay, Caroline Jan, G. Scott Ralph, Katie Binley, Nadja Van Camp, Hannah J Stewart, Yatish Lad, Julie Loader, Stéphane Palfi, Michelle Kelleher, Romina Aron Badin, Camille Robert, Philippe Hantraye, Koichi Hosomi, Pauline Gipchtein, Audrey Fayard, Kyriacos A. Mitrophanous
Publikováno v:
Molecular Therapy. Methods & Clinical Development
A recent phase I-II, open-label trial of ProSavin, a lentiviral vector delivering the key enzymes in the dopamine biosynthetic pathway to non-dopaminergic striatal neurons, demonstrated safety and improved motor function in parkinsonian patients. How
Autor:
Philip C. Buttery, Richard Harrop, Helene Lepetit, Claire Thiriez, Xavier Drouot, G. Scott Ralph, Jean Pascal Lefaucheur, Cherry Lucas, Philippe Le Corvoisier, Pippa A Radcliffe, Philippe Hantraye, Patrice Dolphin, Pierre Brugières, Hirokazu Iwamuro, Sarah L Mason, Olivier Rascol, Gilles Fénelon, David P. Breen, Inanna Gabriel, Sarah Deeley, Michelle Kelleher, Sonia Lavisse, Kou Abhay, Aurélie Kas, Stuart Naylor, Roger A. Barker, Jean Marc Gurruchaga, Pierre Cesaro, Natalie Valle Guzman, Stéphane Palfi, Colin Watts, Kyriacos A. Mitrophanous, Nicholas D. Mazarakis, Bijan Ghaleh, James Miskin, Philippe Remy, Naoki Tani, Susan M. Kingsman
Publikováno v:
The Lancet. 383:1138-1146
Summary Background Parkinson's disease is typically treated with oral dopamine replacement therapies; however, long-term treatment leads to motor complications and, occasionally, impulse control disorders caused by intermittent stimulation of dopamin
Autor:
Richard Harrop, Stuart Naylor, Michelle Kelleher, Peter Treasure, Gemma Bolton, William Shingler, Jackie de Belin
Publikováno v:
Cancer Immunology, Immunotherapy. 61:2283-2294
Cancer vaccines such as MVA-5T4 (TroVax(®)) must induce an efficacious immune response to deliver therapeutic benefit. The identification of biomarkers that impact on the clinical and/or immunological efficacy of cancer vaccines is required in order
Autor:
Liang Fong-Wong, G. Scott Ralph, Vinay Thoree, Michelle Kelleher, Iain T. Strickland, Kyriacos A. Mitrophanous, Hannah J Stewart, Pippa A Radcliffe, Laura Stevenson, Janine McCarthy, Daniel Chipchase
Publikováno v:
Human Gene Therapy. 22:357-369
ProSavin is an equine infectious anemia virus vector-based gene therapy for Parkinson's disease for which inducible HEK293T-based producer cell lines (PCLs) have been developed. These cell lines demonstrate stringent tetracycline-regulated expression
Publikováno v:
Journal of Cancer Therapy. :54-64
Modified vaccinia Ankara (MVA) virus encoding the tumor antigen 5T4 (MVA-5T4; TroVax?) has been tested in two open-label phase II studies in metastatic colorectal cancer patients alongside two chemotherapy regimens, 5-fluorouracil, folinic acid and i
Publikováno v:
Journal of Immunotherapy. 33:999-1005
The attenuated vaccinia virus MVA has been engineered to deliver the tumor antigen 5T4 (MVA-5T4; TroVax), a surface glycoprotein expressed by most solid tumors. MVA-5T4 has been tested in 2 phase I/II and 7 phase II clinical trials in colorectal (4 t
Publikováno v:
Journal of Contemporary Water Research & Education. 136:1-6
Water and watershed concerns integrate research challenges with human needs and they reflect the global urgency of many strategic, socioeconomic, and environmental crises. Issues of water availability (quantity, quality, timing), ecosystem functions