Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michelle Kassner"'
Autor:
Michelle Kassner, J. Brek Eaton, Nanyun Tang, Joachim L. Petit, Nathalie Meurice, Hongwei Holly Yin, Paul Whiteaker
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 68-76 (2022)
There is substantial evidence that in addition to nicotine, other compounds found in tobacco smoke significantly influence smoking behavior. Further, recent years have seen an explosion in the availability of non-combusted products that deliver nicot
Externí odkaz:
https://doaj.org/article/69bed0571f2b4e86ad58d7d3b8564877
Autor:
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109291- (2021)
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative a
Externí odkaz:
https://doaj.org/article/24ff658919d8494e80b28117e73c541b
Autor:
Kevin S. Kapner, William C. Hahn, Nanyun Tang, Hongwei H. Yin, Kaisheng Chen, Michelle Kassner, Bjoern Papke, Thomas S. K. Gilbert, A. Cole Edwards, J. Nathaniel Diehl, Sehrish Javaid, Tala O. Khatib, Devon R. Blake, Kajal R. Grover, James M. McFarland, Katherine H. Walsh, Tikvah K. Hayes, Manpreet Kalkat, Katherine M. Nowak, Channing J. Der, G. Aaron Hobbs, Olga Tanaseichuk, Adele Waters, Lee M. Graves, Antje Schaefer, Adrienne D. Cox, Clint A. Stalnecker, Linda Z. Penn, Craig M. Goodwin, Anna Barkovskaya, Andrew J. Aguirre, Priya S. Hibshman, Jennifer E. Klomp, Yingyao Zhou, Laura E. Herring, Rita Sulahian, Runying Yang
Publikováno v:
Cell reports
Cell Reports, Vol 35, Iss 13, Pp 109291-(2021)
Cell Reports, Vol 35, Iss 13, Pp 109291-(2021)
SUMMARY To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa70e97d6bf8eeb43a46832a616c256d
https://pubmed.ncbi.nlm.nih.gov/34192548
https://pubmed.ncbi.nlm.nih.gov/34192548
Autor:
Kevin K. Kapner, Anna Barkovskaya, Nanyun Tang, Adele Waters, Lee M. Graves, Devon R. Blake, Bjoern Papke, Andrew J. Aguirre, Tala O. Khatib, Yingyao Zhou, James M. McFarland, William C. Hahn, Kajal R. Grover, Katherine H. Walsh, J. Nathaniel Diehl, Tikvah K. Hayes, Kaisheng Chen, Clint A. Stalnecker, Katherine M. Nowak, Laura E. Herring, Craig M. Goodwin, Rita Sulahian, Sehrish Javaid, Jennifer E. Klomp, Channing J. Der, Olga Tanaseichuk, Thomas S. K. Gilbert, G. Aaron Hobbs, Adrienne D. Cox, Michelle Kassner, Hongwei Yin, Antje Schaefer
Publikováno v:
SSRN Electronic Journal.
To identify therapeutic targets for KRAS-mutant pancreatic cancer, we conducted a druggable genome siRNA screen and determined that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative analysis of genome-scale CRISPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d0a6be0e4a38f111160286aedaefca2
https://doi.org/10.2139/ssrn.3664181
https://doi.org/10.2139/ssrn.3664181
Autor:
Yoon-La Choi, Joon Oh Park, Ahye Cho, Joshua M. Francis, Kyoung-Mee Kim, Angela K.J. Park, JaeHyung Koo, Meraj Aziz, Je-Gun Joung, Michelle Kassner, Woong-Yang Park, Myung-Ju Ahn, Hideo Watanabe, Jeonghee Cho, Nayoung Kim, Hongwei Holly Yin, Joon Seol Bae, Keunchil Park, Soo Min Ahn
Publikováno v:
Oncotarget
Therapies targeting the tyrosine kinase activity of Epidermal Growth Factor Receptor (EGFR) have been proven to be effective in treating a subset of non-small cell lung cancer (NSCLC) patients harboring activating EGFR mutations. Inevitably these pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e61a421b1881319ef48b9f62c109ae
https://doi.org/10.18632/oncotarget.7318
https://doi.org/10.18632/oncotarget.7318
Autor:
Nicholas Helle, Stephanie F. Williams, Varun Maher, Michelle Kassner, Gerri Ortiz, Stephen C. Logie, Chao Sima, Mark Miglarese, Tassilo Hornung, Matthew Rosenow, Perrin Mok, David Spetzler, Heather A. O'Neill, Teresa L. Tinder
Publikováno v:
Cancer Research. 80:5165-5165
Identification of novel biomarkers and drug targets for colorectal cancer remains a critically unmet medical need. Target identification has historically been driven by preclinical models which poorly recapitulate the complex biology of human cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fd6c00b79155564e2292f1ee32ca4f5
https://doi.org/10.1158/1538-7445.am2020-5165
https://doi.org/10.1158/1538-7445.am2020-5165
Autor:
Michelle Kassner, Jelena Zarkovic, Michael Famulok, Matthew Rosenow, Günter Mayer, David Spetzler, Mark Miglarese, Tassilo Hornung
Publikováno v:
Cancer Research. 79:3136-3136
Disease biomarkers play an essential role in disease-diagnostics and in monitoring their responses to therapies. Identification of low to medium abundance biomarkers is one of the biggest challenges in the field. We have developed Adaptive Dynamic Ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e8f8c1202fb72e1c39f1cf4c67f0965
https://doi.org/10.1158/1538-7445.am2019-3136
https://doi.org/10.1158/1538-7445.am2019-3136
Autor:
Hongwei, Yin, Michelle, Kassner
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1470
High-throughput RNA interference (HT-RNAi) is a powerful tool that can be used to knock down gene expression in order to identify novel genes and pathways involved in many cellular processes. It is a systematic, yet unbiased, approach to identify ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ada0e888da8beaa5e0399fa74c69958f
https://pubmed.ncbi.nlm.nih.gov/27581290
https://pubmed.ncbi.nlm.nih.gov/27581290
Autor:
Hongwei Yin, Michelle Kassner
Publikováno v:
Methods in Molecular Biology ISBN: 9781493963355
High-throughput RNA interference (HT-RNAi) is a powerful tool that can be used to knock down gene expression in order to identify novel genes and pathways involved in many cellular processes. It is a systematic, yet unbiased, approach to identify ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75b44c49aad17f4027d64629c47fcd53
https://doi.org/10.1007/978-1-4939-6337-9_11
https://doi.org/10.1007/978-1-4939-6337-9_11
Autor:
Daniel D. Von Hoff, Lifang Xie, Haiyong Han, Spyro Mousses, Jeff Kiefer, Yu Zhao, Michelle Kassner, Ruben M. Munoz, Hongwei H. Yin, Qiang Q. Que
Publikováno v:
Biochemical Pharmacology. 83:452-461
Aurora kinases are a family of mitotic kinases that play important roles in the tumorigenesis of a variety of cancers including pancreatic cancer. A number of Aurora kinase inhibitors (AKIs) are currently being tested in preclinical and clinical sett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf09d84caae51c7f7bc790939eecfebd
https://doi.org/10.1016/j.bcp.2011.11.005
https://doi.org/10.1016/j.bcp.2011.11.005