Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michelle K. Greene"'
Autor:
Michelle K. Greene, Peter Smyth, Andrew English, Joseph McLaughlin, Magda Bucholc, Janice Bailie, Julie McCarroll, Margaret McDonnell, Alison Watt, George Barnes, Mark Lynch, Kevan Duffin, Gerard Duffy, Claire Lewis, Jacqueline A. James, Alan W. Stitt, Tom Ford, Maurice O'Kane, Taranjit Singh Rai, Anthony J. Bjourson, Christopher Cardwell, J Stuart Elborn, David S. Gibson, Christopher J. Scott
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e24184- (2024)
Background: With the spread of SARS-CoV-2 impacting upon public health directly and socioeconomically, further information was required to inform policy decisions designed to limit virus spread during the pandemic. This study sought to contribute to
Externí odkaz:
https://doaj.org/article/7d4d4ec7cbc4481399abfb0592ef4565
Autor:
Anitha Krishnan, Victor G. Sendra, Diyan Patel, Amit Lad, Michelle K. Greene, Peter Smyth, Samantha A. Gallaher, Úna M. Herron, Christopher J. Scott, Mohamed Genead, Michael Tolentino
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Age-related macular degeneration (AMD) is a chronic, progressive retinal disease characterized by an inflammatory response mediated by activated macrophages and microglia infiltrating the inner layer of the retina. In this study, we demonstrate that
Externí odkaz:
https://doaj.org/article/1695d0f4dbaf4e15b53f9d3640d3999b
Autor:
Anitha Krishnan, David G. Callanan, Victor G. Sendra, Amit Lad, Sunny Christian, Ravinder Earla, Ali Khanehzar, Andrew J. Tolentino, Valory Anne Sarmiento Vailoces, Michelle K. Greene, Christopher J. Scott, Derek Y. Kunimoto, Tarek S. Hassan, Mohamed A. Genead, Michael J. Tolentino
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 481 (2024)
An inflammation-resolving polysialic acid-decorated PLGA nanoparticle (PolySia-NP) has been developed to treat geographic atrophy/age-related macular degeneration and other conditions caused by macrophage and complement over-activation. While PolySia
Externí odkaz:
https://doaj.org/article/a214705fd1b04dce98986778fed379cd
Autor:
Fabien Thoreau, Peter A. Szijj, Michelle K. Greene, Léa N. C. Rochet, Ioanna A. Thanasi, Jaine K. Blayney, Antoine Maruani, James R. Baker, Christopher J. Scott, Vijay Chudasama
Publikováno v:
Thoreau, F, Szijj, P A, Greene, M K, Rochet, L N C, Thanasi, I A, Blayney, J K, Maruani, A, Baker, J R, Scott, C J & Chudasama, V 2023, ' Modular chemical construction of IgG-like mono-and bispecific synthetic antibodies (SynAbs) ', ACS Central Science, vol. 9, no. 3, pp. 476-487 . https://doi.org/10.1021/acscentsci.2c01437
In recent years there has been rising interest in the field of protein–protein conjugation, especially related to bispecific antibodies (bsAbs) and their therapeutic applications. These constructs contain two paratopes capable of binding two distin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54408a605bd6acd6895ca5b37f529f0
https://pure.qub.ac.uk/en/publications/5f277b29-755b-45e5-9f63-7465bbb31441
https://pure.qub.ac.uk/en/publications/5f277b29-755b-45e5-9f63-7465bbb31441
Autor:
Giovanna Bossi, Michelle K. Greene, Peter Smyth, Nikolai Lissin, William J. McDaid, Christopher J. Scott, Daniel B. Longley, Adam Leach, Ellen Pollheimer, David K. Cole
Publikováno v:
McDaid, W J, Lissin, N, Pollheimer, E, Greene, M, Leach, A, Smyth, P, Bossi, G, Longley, D, Cole, D K & Scott, C J 2021, ' Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors ', Nanoscale, vol. 13, no. 35, pp. 15010-15020 . https://doi.org/10.1039/d1nr04001d
Nanoscale
Nanoscale
For effective targeted therapy of cancer with chemotherapy-loaded nanoparticles (NPs), antigens that are selective for cancer cells should be targeted to minimise off-tumour toxicity. Human leukocyte antigens (HLAs) are attractive cancer targets as t
Autor:
Ninfa L. Straubinger, Stephen Caddick, Daniel B. Longley, James F Burrows, Darren K.W. Chan, Charlene Minx, Michelle K. Greene, Jun Wang, Robert M. Straubinger, Sandra Van Schaeybroeck, James R. Baker, Vijay Chudasama, Eifion Robinson, Ting Chen, Christopher J. Scott, Donald E. Mager
Publikováno v:
Greene, M K, Chen, T, Robinson, E, Straubinger, N L, Minx, C, Chan, D K W, Wang, J, Burrows, J F, Van Schaeybroeck, S, Baker, J R, Caddick, S, Longley, D B, Mager, D E, Straubinger, R M, Chudasama, V & Scott, C J 2020, ' Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer ', British Journal of Cancer . https://doi.org/10.1038/s41416-020-01046-6
British Journal of Cancer
British Journal of Cancer
Background Antibody-drug conjugate (ADC) construction poses numerous challenges that limit clinical progress. In particular, common bioconjugation methods afford minimal control over the site of drug coupling to antibodies. Here, such difficulties ar
Autor:
Martin Clynes, Michael C. Johnston, Katie Stott, William J. McDaid, Julie A. Nicoll, Michelle K. Greene, Robert M. Straubinger, Darren K.W. Chan, Daniel B. Longley, Christopher J. Scott, Sandra Roche, Ninfa L. Straubinger, Jennifer Fox, Kelly M. Redmond, Nyree Crawford, Peter Smyth
Publikováno v:
J Control Release
Johnston, M, Nicoll, J, Redmond, K, Smyth, P, Greene, M, McDaid, W, Crawford, N, Stott, K, Fox, J, Longley, D & Scott, C 2020, ' DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models ', Journal of Controlled Release, vol. 324, pp. 610-619 . https://doi.org/10.1016/j.jconrel.2020.05.046
Johnston, M, Nicoll, J, Redmond, K, Smyth, P, Greene, M, McDaid, W, Crawford, N, Stott, K, Fox, J, Longley, D & Scott, C 2020, ' DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models ', Journal of Controlled Release, vol. 324, pp. 610-619 . https://doi.org/10.1016/j.jconrel.2020.05.046
Pancreatic cancer is usually advanced and drug resistant at diagnosis. A potential therapeutic approach outlined here uses nanoparticle (NP)-based drug carriers, which have unique properties that enhance intra-tumor drug exposure and reduce systemic
Autor:
Vijay Chudasama, Andrew J. Porter, Michelle K. Greene, Daniel A. Richards, Christopher J. Scott, Caroline J. Barelle, John Steven, Alexander O. Furby, João C. F. Nogueira
Publikováno v:
Nogueira, J C F, Greene, M K, Richards, D A, Furby, A O, Steven, J, Porter, A, Barelle, C, Scott, C J & Chudasama, V 2019, ' Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance ', Chemical Communications, vol. 55, no. 53, pp. 7671-7674 . https://doi.org/10.1039/c9cc02655j
Chemical Communications
Chemical Communications
Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly la
Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature
Autor:
Laura A. Ferguson, Michelle K. Greene, Cristina Branco, Caroline J. Barelle, Andrew J. Porter, Christopher J. Scott, Aidan P. McCann, John Steven, Adam Leach, Peter Smyth
Publikováno v:
Leach, A, Smyth, P, Ferguson, L, Steven, J, Greene, M K, Branco, C M, McCann, A P, Porter, A, Barelle, C J & Scott, C J 2020, ' Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature ', Nanoscale, vol. 12, no. 27, pp. 14751-14763 . https://doi.org/10.1039/d0nr02962a
Whilst there is an extensive body of preclinical nanomedicine research, translation to clinical settings has been slow. Here we present a novel approach to the targeted nanoparticle (NP) concept: utilizing both a novel targeting ligand, VNAR (Variabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9000d85798e3ba9a09942ab56951fdc9
https://pure.qub.ac.uk/en/publications/bf2ce826-7237-4bae-9ed0-c6f6a9d15d0e
https://pure.qub.ac.uk/en/publications/bf2ce826-7237-4bae-9ed0-c6f6a9d15d0e
Autor:
Shannon R Tracey, João C. F. Nogueira, Vijay Chudasama, Daniel B. Longley, Michelle K. Greene, Christopher J. Scott, Katrina Campbell, Daniel A. Richards, James F Burrows, William J. McDaid
Publikováno v:
Greene, M, Nogueira, J, Tracey, S, Richards, D, McDaid, W, Burrows, J, Campbell, K, Longley, D, Chudasama, V & Scott, C 2020, ' Refined construction of antibody-targeted nanoparticles leads to superior antigen binding and enhanced delivery of an entrapped payload to pancreatic cancer cells ', Nanoscale, vol. 2020, no. 12, 11647 . https://doi.org/10.1039/D0NR02387F
Antibody-targeted nanoparticles have shown exceptional promise as delivery vehicles for anticancer drugs, although manufacturability challenges have hampered clinical progress. These include the potential for uncontrolled and random antibody conjugat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f893dab60e18b0e554fe9535ac79b22f
https://pure.qub.ac.uk/en/publications/e74060ad-cf48-4a73-ae1e-886657d440c9
https://pure.qub.ac.uk/en/publications/e74060ad-cf48-4a73-ae1e-886657d440c9