Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michelle K. Nahas"'
Autor:
Sungchul Hohng, Jin Yu, Klaus Schulten, Michelle K. Nahas, David M.J. Lilley, Ruobo Zhou, Taekjip Ha
Publikováno v:
Science. 318:279-283
Despite the recent advances in single-molecule manipulation techniques, purely mechanical approaches cannot detect subtle conformational changes in the biologically important regime of weak forces. We developed a hybrid scheme combining force and flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ee3084836582f610c465d2f2c35a3
https://doi.org/10.1126/science.1146113
https://doi.org/10.1126/science.1146113
Autor:
Timothy J. Wilson, Michelle K. Nahas, Taekjip Ha, Shinya Harusawa, David M.J. Lilley, Lisa Araki
Publikováno v:
Blood Cells, Molecules, and Diseases. 38:8-14
The nucleolytic ribozymes catalyse site-specific phosphodiester cleavage and ligation transesterification reactions in RNA. The hairpin ribozyme folds to generate an intimate loop-loop interaction to create the local environment in which catalysis ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abab9d96ea4ce4f227725b88b40b288e
https://doi.org/10.1016/j.bcmd.2006.10.004
https://doi.org/10.1016/j.bcmd.2006.10.004
Publikováno v:
Biochemical Society Transactions. 33:461-465
The active form of the hairpin ribozyme is brought about by the interaction of two formally unpaired loops. In a natural molecule, these are present on two adjacent arms of a four-way junction. Although activity can be obtained in molecules lacking t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471a7d75b0c795b1192c0e30c3a411d5
https://doi.org/10.1042/bst0330461
https://doi.org/10.1042/bst0330461
Autor:
Elliot Tan, David M.J. Lilley, Michelle K. Nahas, Taekjip Ha, Timothy J. Wilson, Robert M. Clegg
Publikováno v:
Proceedings of the National Academy of Sciences. 100:9308-9313
The natural form of the hairpin ribozyme comprises two major structural elements: a four-way RNA junction and two internal loops carried by adjacent arms of the junction. The ribozyme folds into its active conformation by an intimate association betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cf00b8bfb17f02a3876411ce960205
https://doi.org/10.1073/pnas.1233536100
https://doi.org/10.1073/pnas.1233536100
Autor:
Jeffrey R. Krogmeier, Bryan Crane, Griffis Joshua, Lisa W. Kwok, Rudolf Gilmanshin, Nanor Kojanian, Michelle K. Nahas, Qun Zhong, Vyacheslav Papkov, Saad Shaikh, Richard Allen, Gene Malkin, Kedar Vyavahare, Robert H. Meltzer, Jonathan W. Larson, Yi Zhou, Linda Knaian
Publikováno v:
Lab on a chip. 11(5)
Rapid, specific, and sensitive detection of airborne bacteria, viruses, and toxins is critical for biodefense, yet the diverse nature of the threats poses a challenge for integrated surveillance, as each class of pathogens typically requires differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7225b18afc68c0c7d8513bad723047fc
https://pubmed.ncbi.nlm.nih.gov/21249264
https://pubmed.ncbi.nlm.nih.gov/21249264
Publikováno v:
Biochemistry
Purine riboswitches are RNA regulatory elements that control purine metabolism in response to intracellular concentrations of the purine ligands. Conformational changes of the guanine riboswitch aptamer domain induced by guanine binding lead to trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716de72472e66178e9ebf1ab61e69c0b
https://pubmed.ncbi.nlm.nih.gov/20108980
https://pubmed.ncbi.nlm.nih.gov/20108980
Autor:
Kaera Jarvie, Sungchul Hohng, Timothy J. Wilson, Taekjip Ha, David M.J. Lilley, Michelle K. Nahas
Publikováno v:
Nature structuralmolecular biology. 11(11)
We have used single-molecule spectroscopy to untangle conformational dynamics and internal chemistry in the hairpin ribozyme. The active site of the ribozyme is stably formed by docking two internal loops, but upon cleavage undocking is accelerated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e287625fb39285aee670470a83a5425
https://pubmed.ncbi.nlm.nih.gov/15475966
https://pubmed.ncbi.nlm.nih.gov/15475966
Autor:
Anne-Cécile Déclais, Taekjip Ha, Sean A. McKinney, David M.J. Lilley, Michelle K. Nahas, Timothy J. Wilson, Robert M. Clegg, Elliot Tan
Publikováno v:
Biochemical Society transactions. 32(Pt 1)
Branched helical junctions are common in nucleic acids. In DNA, the four-way junction (Holliday junction) is an essential intermediate in homologous recombination and is a highly dynamic structure, capable of stacking conformer transitions and branch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3db26577f2d3ea80ab5b0b3b76af424
https://pubmed.ncbi.nlm.nih.gov/14748709
https://pubmed.ncbi.nlm.nih.gov/14748709
Autor:
Jeffrey R Gardner, Michelle K. Nahas, Jie He, Minal Patel, Kristina M. Knapp, M. Lia Palomba, Roman Yelensky, Amy L Donahue, Geoff A. Otto, Maria Arcila, Ahmet Dogan, Jae H Park, Andrew D. Zelenetz, Doron Lipson, Martin S. Tallman, Ross L. Levine, Philip J. Stephens, Marcel R. M. van den Brink, Vincent A. Miller, Mark L Heaney, Omar Abdel-Wahab
Publikováno v:
Blood. 122:2858-2858
Recent whole-genome sequencing, whole-exome sequencing, and copy number analysis studies in small sets of patients with chronic lymphocytic leukemia (CLL) at presentation versus progression have demonstrated that clonal evolution has clinical and bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3730a764ca987a15127c3ceee58de39
https://doi.org/10.1182/blood.v122.21.2858.2858
https://doi.org/10.1182/blood.v122.21.2858.2858
Autor:
Andrei V. Krivtsov, Wang Xujun, Noushin Rahnamay Farnoud, Michael Hadler, Kristina M. Knapp, Eytan M Stein, Martin S. Tallman, Amy L Donahue, Doron Lipson, Michelle K. Nahas, Philip J. Stephens, Eric M Sanford, Kai Wang, Garrett M Frampton, Tim Brennan, Geoff A. Otto, Roman Yelensky, Vincent A. Miller, Ross L. Levine, Scott A. Armstrong
Publikováno v:
Blood. 122:1328-1328
Xenotransplantation of primary AML samples into immunodeficient mice (PDX models) represents a unique opportunity for pre-clinical testing on a group of primary human samples that possess defined genetic lesions. However, given our recent recognition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a737204e2db34f80d943b9128857d80
https://doi.org/10.1182/blood.v122.21.1328.1328
https://doi.org/10.1182/blood.v122.21.1328.1328