Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets

Autor: Kunihiro Matsushita, Simerjot K Jassal, Yingying Sang, Shoshana H Ballew, Morgan E Grams, Aditya Surapaneni, Johan Arnlov, Nisha Bansal, Milica Bozic, Hermann Brenner, Nigel J Brunskill, Alex R Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai-Uwe Eckardt, Ron T Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih-Jen Hwang, Tazeen H Jafar, Takamasa Kayama, Csaba P Kovesdy, Gijs W Landman, Andrew S Levey, Donald M Lloyd-Jones, Rupert W. Major, Katsuyuki Miura, Paul Muntner, Girish N Nadkarni, David MJ Naimark, Christoph Nowak, Takayoshi Ohkubo, Michelle J Pena, Kevan R Polkinghorne, Charumathi Sabanayagam, Toshimi Sairenchi, Markus P Schneider, Varda Shalev, Michael Shlipak, Marit D Solbu, Nikita Stempniewicz, James Tollitt, José M Valdivielso, Joep van der Leeuw, Angela Yee-Moon Wang, Chi-Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Elke Schaeffner, Josef Coresh

Publikováno v: EClinicalMedicine, Vol 27, Iss , Pp 100552- (2020)

Background: Chronic kidney disease (CKD) measures (estimated glomerular filtration rate [eGFR] and albuminuria) are frequently assessed in clinical practice and improve the prediction of incident cardiovascular disease (CVD), yet most major clinical

Externí odkaz: https://doaj.org/article/998af47783114dca839d455850f5705b

Urinary liver-type fatty-acid binding protein is independently associated with graft failure in outpatient kidney transplant recipients

Autor: Rijk O. B. Gans, Stefan P Berger, Gerjan Navis, Stephan J. L. Bakker, Takeshi Sugaya, Michele F Eisenga, Camilo G. Sotomayor, Jaap van den Born, Michelle J Pena, Dew Doekharan, Cyril Moers, Manuela Yepes-Calderón

Publikováno v: American Journal of Transplantation, 21(4), 1535-1544. Wiley
American Journal of Transplantation

Urinary liver‐type fatty acid‐binding protein (uL‐FABP) is a biomarker of kidney hypoxia and ischemia, and thus offers a novel approach to identify early kidney insults associated with increased risk of graft failure in outpatient kidney transp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7959576135414bd809ed8f2b47b1e2
https://hdl.handle.net/11370/5acd5c45-b405-4940-a7ec-ae1eb08b17a8

Baseline urinary metabolites predict albuminuria response to spironolactone in type 2 diabetes

Autor: Hiddo J.L. Heerspink, Uzma F. Mehdi, Paul Perco, Michelle J Pena, Ib Abildgaard Jacobsen, Thomas Hankemeier, Skander Mulder, Christina Stolzenburg Oxlund, Robert D. Toto

Publikováno v: Translational Research, 222, 17-27. ELSEVIER SCIENCE INC
Mulder, S, Perco, P, Oxlund, C, Mehdi, U F, Hankemeier, T, Jacobsen, I A, Toto, R, Heerspink, H J L & Pena, M J 2020, ' Baseline urinary metabolites predict albuminuria response to spironolactone in type 2 diabetes ', Translational Research, vol. 222, pp. 17-27 . https://doi.org/10.1016/j.trsl.2020.04.010
Translational Research

The mineralocorticoid receptor antagonist spironolactone significantly reduces albuminuria in subjects with diabetic kidney disease, albeit with a large variability between individuals. Identifying novel biomarkers that predict response to therapy ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd292bd7e4255fb2526402d380a020b5
https://doi.org/10.1016/j.trsl.2020.04.010

Proteinuria and cholesterol reduction are independently associated with less renal function decline in statin-treated patients; apost hoc analysis of the PLANET trials

Autor: Michelle J Pena, Hiddo J.L. Heerspink, Dick de Zeeuw, Hans-Henrik Parving, Nienke M. A. Idzerda

Publikováno v: Nephrology Dialysis Transplantation
Nephrology, Dialysis, Transplantation, 34(10), 1699-1706. Oxford University Press

Background Statins have shown multiple effects on different renal risk factors such as lowering of total cholesterol (TC) and lowering of urine protein:creatinine ratio (UPCR). We assessed whether these effects of statins vary between individuals, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f9aa4d9a2e3400f25eb995ecc58e95
https://research.rug.nl/en/publications/7d1820b9-16b2-4194-a47b-1d99bfb3856a

Prediction of the effect of dapagliflozin on kidney and heart failure outcomes based on short-term changes in multiple risk markers

Autor: Michelle J Pena, David C. Wheeler, David C Sjostrom, Bergur V. Stefánsson, Hiddo J.L. Heerspink, Nienke M. A. Idzerda

Publikováno v: Nephrology, Dialysis, Transplantation, 35(9):gfz064, 1570-1576. Oxford University Press
Nephrology Dialysis Transplantation

Background Besides improving glucose control, sodium-glucose co-transporter 2 inhibition with dapagliflozin reduces blood pressure, body weight and urinary albumin:creatinine ratio (UACR) in patients with type 2 diabetes (T2DM). The parameter respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d6d92b7ee9965e17a0d9ab44cfd1ab
https://research.rug.nl/en/publications/3c230131-e6d9-48b3-8e4d-cb9d61467a72