Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michelle J. Choi"'
Autor:
Ki Woo Kim, Jeffrey M. Zigman, Jennifer W. Hill, Laurent Gautron, Danielle A. Lauzon, Joel K. Elmquist, Charlotte E. Lee, Michelle J. Choi, Jean J. Zhao, Bradford B. Lowell, Jong Woo Sohn, Makoto Fukuda, Yong Xu, Harveen Dhillon
Publikováno v:
Cell Metabolism. 12(1):88-95
SummaryPhosphatidyl inositol 3-kinase (PI3K) signaling in the hypothalamus has been implicated in the regulation of energy homeostasis, but the critical brain sites where this intracellular signal integrates various metabolic cues to regulate food in
Autor:
Kevin W. Williams, Carol F. Elias, Joel K. Elmquist, Syann Lee, Charlotte E. Lee, Michelle J. Choi, Michael Scott, Lisandra O. Margatho
Publikováno v:
The Journal of Neuroscience. 30:2472-2479
Acute leptin administration results in a depolarization and concomitant increase in the firing rate of a subpopulation of arcuate proopiomelanocortin (POMC) cells. This rapid activation of POMC cells has been implicated as a cellular correlate of lep
Autor:
Jeffrey M. Zigman, Jennifer W. Hill, Michelle J. Choi, Charlotte E. Lee, Joel K. Elmquist, David P. Olson, Laurent Gautron, Juli E. Jones, Makoto Fukuda, Bradford B. Lowell
Publikováno v:
The Journal of Neuroscience. 28:13640-13648
The PI3K-Akt-FoxO1 pathway contributes to the actions of insulin and leptin in several cell types, including neurons in the CNS. However, identifying these actions in chemically identified neurons has proven difficult. To address this problem, we hav
Autor:
Michael Scott, Eric D. Berglund, Jari Rossi, David P. Olson, Joel K. Elmquist, Bradford B. Lowell, Michelle J. Choi, Danielle A. Lauzon, Nina Balthasar, Charlotte E. Lee
Publikováno v:
Cell Metabolism. (2):195-204
SummaryMelanocortin-4 receptor (MC4R) mutations cause dysregulation of energy balance and hyperinsulinemia. We have used mouse models to study the physiological roles of extrahypothalamic MC4Rs. Re-expression of MC4Rs in cholinergic neurons (ChAT-Cre
Autor:
Jeffrey M. Zigman, Charlotte E. Lee, Yong Xu, Michelle J. Choi, Kevin W. Williams, Joel K. Elmquist, Bradford B. Lowell, Juli E. Jones, Lora K. Heisler, Jason G. Anderson, Daisuke Kohno
Publikováno v:
Neuron
Summary Drugs activating 5-hydroxytryptamine 2C receptors (5-HT2CRs) potently suppress appetite, but the underlying mechanisms for these effects are not fully understood. To tackle this issue, we generated mice with global 5-HT2CR deficiency (2C null