Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Michelle J West"'
Autor:
Rajesh Ponnusamy, Ritika Khatri, Paulo B Correia, C David Wood, Erika J Mancini, Paul J Farrell, Michelle J West
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007458 (2019)
Natural variation separates Epstein-Barr virus (EBV) into type 1 and type 2 strains. Type 2 EBV is less transforming in vitro due to sequence differences in the EBV transcription factor EBNA2. This correlates with reduced activation of the EBV oncoge
Externí odkaz:
https://doaj.org/article/d632892b25734a9aacfd5e80f581287a
Autor:
Ieisha Pentland, Karen Campos-León, Marius Cotic, Kelli-Jo Davies, C David Wood, Ian J Groves, Megan Burley, Nicholas Coleman, Joanne D Stockton, Boris Noyvert, Andrew D Beggs, Michelle J West, Sally Roberts, Joanna L Parish
Publikováno v:
PLoS Biology, Vol 16, Iss 10, p e2005752 (2018)
The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted. Upon epithelial differentiation, E6/E7 transcription is increased t
Externí odkaz:
https://doaj.org/article/2b634e44faf441ed83f18dab7b93bedd
Autor:
C David Wood, Hildegonda Veenstra, Sarika Khasnis, Andrea Gunnell, Helen M Webb, Claire Shannon-Lowe, Simon Andrews, Cameron S Osborne, Michelle J West
Publikováno v:
eLife, Vol 5 (2016)
Lymphomagenesis in the presence of deregulated MYC requires suppression of MYC-driven apoptosis, often through downregulation of the pro-apoptotic BCL2L11 gene (Bim). Transcription factors (EBNAs) encoded by the lymphoma-associated Epstein-Barr virus
Externí odkaz:
https://doaj.org/article/d0168bf945bb4d54b7a76064f2dbc58e
Autor:
Michael J McClellan, C David Wood, Opeoluwa Ojeniyi, Tim J Cooper, Aditi Kanhere, Aaron Arvey, Helen M Webb, Richard D Palermo, Marie L Harth-Hertle, Bettina Kempkes, Richard G Jenner, Michelle J West
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003636 (2013)
Epstein-Barr virus (EBV) epigenetically reprogrammes B-lymphocytes to drive immortalization and facilitate viral persistence. Host-cell transcription is perturbed principally through the actions of EBV EBNA 2, 3A, 3B and 3C, with cellular genes dereg
Externí odkaz:
https://doaj.org/article/f1ec0ab7ce444d78be87a77e27947c93
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002334 (2011)
Epstein-Barr virus (EBV) immortalizes resting B-cells and is a key etiologic agent in the development of numerous cancers. The essential EBV-encoded protein EBNA 2 activates the viral C promoter (Cp) producing a message of ~120 kb that is differentia
Externí odkaz:
https://doaj.org/article/e5b5077c83804a5dbe18f926b6accb70
Autor:
Sandra N Schlick, C David Wood, Andrea Gunnell, Helen M Webb, Sarika Khasnis, Aloys Schepers, Michelle J West
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28638 (2011)
Epstein-Barr virus (EBV) is implicated in the pathogenesis of multiple human tumours of lymphoid and epithelial origin. The virus infects and immortalizes B cells establishing a persistent latent infection characterized by varying patterns of EBV lat
Externí odkaz:
https://doaj.org/article/188f6d451de149edb5eb8f2f60f54f2e
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 795 (2024)
Cry toxins, produced by the bacterium Bacillus thuringiensis, are of significant agronomic value worldwide due to their potent and highly specific activity against various insect orders. However, some of these pore-forming toxins display specific act
Externí odkaz:
https://doaj.org/article/92f74c51a754435fa23c185a8c63e30f
Autor:
Sarika Khasnis, Hildegonda Veenstra, Michael J. McClellan, Opeoluwa Ojeniyi, C. David Wood, Michelle J. West
Publikováno v:
Biochemical Journal. 479:2395-2417
The cancer-associated Epstein–Barr virus (EBV) latently infects and immortalises B lymphocytes. EBV latent membrane protein 2A and EBV-encoded microRNAs are known to manipulate B cell receptor signalling to control cell growth and survival and supp
Autor:
Alessandro Agnarelli, Simon Mitchell, Gillian Caalim, C. David Wood, Leanne Milton‐Harris, Timothy Chevassut, Michelle J. West, Erika J. Mancini
Publikováno v:
Hematological oncology. 40(3)
B-cell progenitor fate determinant interferon regulatory factor 4 (IRF4) exerts key roles in the pathogenesis and progression of multiple myeloma (MM), a currently incurable plasma cell malignancy. Aberrant expression of IRF4 and the establishment of
Probing the Mechanism of Action of Cry41Aa on HepG2 through the Establishment of a Resistant Subline
Autor:
Wided Souissi, Tweedie Alistair, Barbara Domanska, Eva Fortea, Michelle J. West, Jean-Louis Schwartz, Neil Crickmore
Publikováno v:
Toxins; Volume 14; Issue 5; Pages: 319
Cry41Aa, also called parasporin-3, belongs to a group of toxins from the entomopathogenic bacterium Bacillus thuringiensis that show activity against human cancer cells. Cry41Aa exhibits preferential cytocidal activity towards HL-60 (human promyelocy