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Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization
Autor:
Melissa M Mangala, Timothy Y M Ng, Jamie I. Vandenberg, Matthew D. Perry, Adam D Hines, Whitney Liang, Chai Ann Ng, Michelle J O Xu, Adam P. Hill
Publikováno v:
Cardiovascular Research. 116:1434-1445
Aims Current treatment for congenital long QT syndrome Type 2 (cLQTS2), an electrical disorder that increases the risk of life-threatening cardiac arrhythmias, is aimed at reducing the incidence of arrhythmia triggers (beta-blockers) or terminating t