Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Michelle I. Arnot"'
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c5f44e8c3df0c12a2c5e793bb9f35e8
https://doi.org/10.1016/j.vascn.2017.09.033
https://doi.org/10.1016/j.vascn.2017.09.033
Publikováno v:
Neuron. 28:195-204
Cysteine string proteins (CSPs) are secretory vesicle proteins bearing a "J domain" and a palmitoylated cysteine-rich "string" region that are critical for neurotransmitter release. The precise role of CSP in neurotransmission is controversial. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b08dac058af2fafad4abf42dd8e8db
https://doi.org/10.1016/s0896-6273(00)00096-9
https://doi.org/10.1016/s0896-6273(00)00096-9
Autor:
Sandra E. File, Michelle I. Arnot, Alan N. Bateson, Cathy Fernandes, Elaine E. Irvine, Ian L. Martin
Publikováno v:
Psychopharmacology. 145:251-259
Rationale: Chronic treatment with benzodiazepines results in tolerance to their sedative and anxiolytic effects and there is considerable evidence that different mechanisms underlie the development of tolerance to different behavioural effects. Objec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd31d981b21d1ba87240e2333d1911bc
https://doi.org/10.1007/s002130051056
https://doi.org/10.1007/s002130051056
Autor:
Yves Couillard, Donald Mackay, Jon A. Arnot, Drew B. MacDonald, Michelle I. Arnot, Pat Doyle, Mark Bonnell
Publikováno v:
Integrated environmental assessment and management. 6(2)
It has been asserted that, when screening chemicals for bioaccumulation potential, molecular size cutoff criteria (or indicators) can be applied above which no, or limited, bioaccumulation is expected. The suggested molecular size values have increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e528b501304d9d495a3736853b2d26de
https://pubmed.ncbi.nlm.nih.gov/19919169
https://pubmed.ncbi.nlm.nih.gov/19919169
Autor:
Robert J. Winkfein, Alexandra E. Kisilevsky, Gerald W. Zamponi, Jawed Hamid, Clinton J. Doering, Aparna Nirdosh, Zhong-Ping Feng, Michelle I. Arnot, Wendy Barr, Brett A. Simms, Jean B. Peloquin
Publikováno v:
The Journal of biological chemistry. 279(28)
The modulation of N-type calcium channels is a key factor in the control of neurotransmitter release. Whereas N-type channels are inhibited by Gbetagamma subunits in a G protein beta-isoform-dependent manner, channel activity is typically stimulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d5b32193e45300d494e636aa18bd50
https://pubmed.ncbi.nlm.nih.gov/15105422
https://pubmed.ncbi.nlm.nih.gov/15105422
Publikováno v:
The Journal of biological chemistry. 276(48)
The direct inhibition of N- and P/Q-type calcium channels by G protein betagamma subunits is considered a key mechanism for regulating presynaptic calcium levels. We have recently reported that a number of features associated with this G protein inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc073e046d97e77b0c40905b24fa1b5c
https://pubmed.ncbi.nlm.nih.gov/11560937
https://pubmed.ncbi.nlm.nih.gov/11560937
Publikováno v:
Journal of neuroscience research. 64(6)
Diazepam is widely prescribed as an anxiolytic but its therapeutic application is limited because with daily use tolerance develops to certain aspects of its pharmacological profile. We compared the effects of two dosing paradigms on GABAA receptor g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7f0cafd28d816602824a979b697757
https://pubmed.ncbi.nlm.nih.gov/11398186
https://pubmed.ncbi.nlm.nih.gov/11398186
Autor:
Michelle I. Arnot, Scott E. Jarvis, Gerald W. Zamponi, Jawed Hamid, Conan B. Cooper, Zhong-Ping Feng
Publikováno v:
The Journal of biological chemistry. 275(52)
The modulation of N-type calcium current by protein kinases and G-proteins is a factor in the fine tuning of neurotransmitter release. We have previously shown that phosphorylation of threonine 422 in the alpha(1B) calcium channel domain I-II linker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c811cc6b9b7bd42a4d9109305a3283b
https://pubmed.ncbi.nlm.nih.gov/11053424
https://pubmed.ncbi.nlm.nih.gov/11053424
Publikováno v:
American Journal of Pharmaceutical Education. 77:63
Objective. To examine academic service-learning pedagogy on student learning and perceptions of drug misuse and addiction. Design. Third- and fourth-year pharmacology students were exposed to an academic service-learning pedagogy that integrated a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99adeba23a6875b61749598600fd395
https://doi.org/10.5688/ajpe77363
https://doi.org/10.5688/ajpe77363
Publikováno v:
Journal of pharmacological and toxicological methods. 36(1)
The functional integrity of Alzet osmotic minipumps was assessed using two organic solvents (50% (v/v) dimethyl sulfoxide (DMSO)/50% (v/v) propylene glycol (PG) and 100% tetraglycol) which dissolve diazepam, an aqueous insoluble benzodiazepine. Both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde16642a4a9198a6703c44c4ad213a7
https://pubmed.ncbi.nlm.nih.gov/8872916
https://pubmed.ncbi.nlm.nih.gov/8872916