Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michelle Hussong"'
Autor:
Julian Kanne, Michelle Hussong, Jörg Isensee, Álvaro Muñoz-López, Jan Wolffgramm, Felix Heß, Christina Grimm, Sergey Bessonov, Lydia Meder, Jie Wang, H. Christian Reinhardt, Margarete Odenthal, Tim Hucho, Reinhard Büttner, Daniel Summerer, Michal R. Schweiger
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-15 (2021)
Abstract Non-coding RNA from pericentromeric satellite repeats are involved in stress-dependent splicing processes, maintenance of heterochromatin, and are required to protect genome stability. Here we show that the long non-coding satellite III RNA
Externí odkaz:
https://doaj.org/article/0959e03a10f843b1a00d0335705383db
Evaluation of a Prognostic Epigenetic Classification System in Chronic Lymphocytic Leukemia Patients
Autor:
Christina Grimm, Carmen Diana Herling, Anastasia Komnidi, Michelle Hussong, Karl-Anton Kreuzer, Michael Hallek, Michal R. Schweiger
Publikováno v:
Biomarker Insights, Vol 17 (2022)
Background: Methylation at 5 CpG sites was previously shown to classify chronic lymphocytic leukemia (CLL) into 3 prognostic subgroups. Here, we aimed to validate the marker set in an additional cohort and to evaluate its clinical utility for CLL pat
Externí odkaz:
https://doaj.org/article/5bb5b4538a634d018c8c66945fbc4cee
Autor:
Maria Herberg, Susann Siebert, Marianne Quaas, Torsten Thalheim, Karen Rother, Michelle Hussong, Janine Altmüller, Christiane Kerner, Joerg Galle, Michal R. Schweiger, Gabriela Aust
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Background Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quantified genome-wide hist
Externí odkaz:
https://doaj.org/article/f3652322832b4382953c498b1a202463
Autor:
Sabrina Grasse, Matthias Lienhard, Steffen Frese, Martin Kerick, Anne Steinbach, Christina Grimm, Michelle Hussong, Jana Rolff, Michael Becker, Felix Dreher, Uwe Schirmer, Stefan Boerno, Anna Ramisch, Gunda Leschber, Bernd Timmermann, Christian Grohé, Heike Lüders, Martin Vingron, Iduna Fichtner, Sebastian Klein, Margarete Odenthal, Reinhard Büttner, Hans Lehrach, Holger Sültmann, Ralf Herwig, Michal R. Schweiger
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Background Non-small cell lung cancer (NSCLC) is the most common cause of cancer-related deaths worldwide and is primarily treated with radiation, surgery, and platinum-based drugs like cisplatin and carboplatin. The major challenge in the t
Externí odkaz:
https://doaj.org/article/84b7234bcdf146459a94256898e040dd
Autor:
Stefan Knapp, Christina Grimm, Cathinka Boedicker, Michal R. Schweiger, Marek Wanior, Michael Meister, Michelle Hussong, Julius C. Enßle, Nadezda Dolgikh, Simone Fulda
Publikováno v:
Oncogene. 39:3837-3852
Remodeling transcription by targeting bromodomain and extraterminal (BET) proteins has emerged as promising anticancer strategy. Here, we identify a novel synergistic interaction of the BET inhibitor JQ1 with the PI3Kα-specific inhibitor BYL719 to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f17a5f30f96e64b46d2c5c25a46679
https://doi.org/10.1038/s41388-020-1229-0
https://doi.org/10.1038/s41388-020-1229-0
Autor:
Holger Thiele, Michal R. Schweiger, Roberta Castiglione, Matthias Lienhard, Michelle Hussong, Anne M. Schultheis, Axel Fischer, Roshni Kalachand, Christina Grimm, Janine Altmüller, Reinhard Buettner, H. Christian Reinhardt, Elena Wasserburger, Bryan T. Hennessy, Ralf Herwig, Kai Hauschulz, Angela M. Farrelly
Publikováno v:
The Journal of Molecular Diagnostics
Current molecular tumor diagnostics encompass panel sequencing to detect mutations, copy number alterations, and rearrangements. However, tumor suppressor genes can also be inactivated by methylation within their promoter region. These epigenetic alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dc23ca57b8ae51e1effa50a0f61ba7
https://doi.org/10.1016/j.jmoldx.2018.10.007
https://doi.org/10.1016/j.jmoldx.2018.10.007
Autor:
Michal R. Schweiger, Tim Hucho, Jan Wolffgramm, Álvaro Muñoz-López, Christina Grimm, Jörg Isensee, Julian Kanne, Michelle Hussong, Felix Heß, Margarete Odenthal, Reinhard Büttner, Daniel Summerer, Lydia Meder, Jie Wang, H. Christian Reinhardt, Sergey Bessonov
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 6, Pp 1-15 (2021)
Cell Death and Disease, Vol 12, Iss 6, Pp 1-15 (2021)
Non-coding RNA from pericentromeric satellite repeats are involved in stress-dependent splicing processes, maintenance of heterochromatin, and are required to protect genome stability. Here we show that the long non-coding satellite III RNA (SatIII)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c82212e09e5e3b42f7569a7f61d142
https://doi.org/10.1038/s41419-021-03810-9
https://doi.org/10.1038/s41419-021-03810-9
Autor:
Anne Jung, Julian Kanne, Alvaro Munoz-Lopez, Benjamin Buchmuller, Michal R. Schweiger, Michelle Hussong, Jan Wolffgramm, Daniel Summerer
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
We report programmable receptors for the imaging‐based analysis of 5‐methylcytosine (5mC) in user‐defined DNA sequences of single cells. Using fluorescent transcription‐activator‐like effectors (TALEs) that can recognize sequences of canoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6897648b0cdd327b0d4bc5d5ff339c
Autor:
Cathinka, Boedicker, Michelle, Hussong, Christina, Grimm, Nadezda, Dolgikh, Michael T, Meister, Julius C, Enßle, Marek, Wanior, Stefan, Knapp, Michal R, Schweiger, Simone, Fulda
Publikováno v:
Oncogene. 39(19)
Remodeling transcription by targeting bromodomain and extraterminal (BET) proteins has emerged as promising anticancer strategy. Here, we identify a novel synergistic interaction of the BET inhibitor JQ1 with the PI3Kα-specific inhibitor BYL719 to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42fc73456e5354497de795944d6a312a
https://pubmed.ncbi.nlm.nih.gov/32161312
https://pubmed.ncbi.nlm.nih.gov/32161312
Autor:
Gabriela Aust, Maria Herberg, Michal R. Schweiger, Michelle Hussong, Janine Altmüller, Marianne Quaas, Susann Siebert, Joerg Galle, Christiane Kerner, Karen Rother, Torsten Thalheim
Publikováno v:
Clinical Epigenetics
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-12 (2019)
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-12 (2019)
Background Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quantified genome-wide histone H3 me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff13d607284a362beb4cc514560733be
https://pubmed.ncbi.nlm.nih.gov/31029155
https://pubmed.ncbi.nlm.nih.gov/31029155