Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Michelle Horner"'
Autor:
Jeffrey Clarine, Qingyian Liu, Beth D. Youngblood, Chester Chenguang Yuan, Michelle Horner, James Brown, Jian J. Chen, Michael D. Bartberger, Vu Van Ma, Matthew R. Kaller, Carl D. Davis, Maosheng Zhang, Thomas T. Nguyen, Narender R. Gavva, Scott Harried, Sonya G. Lehto, Jennifer R. Allen, Holger Monenschein, Daniel B. Horne, Vijay Keshav Gore, Wenge Zhong, Kaustav Biswas
Publikováno v:
Journal of medicinal chemistry. 61(18)
Transient-receptor-potential melastatin 8 (TRPM8), the predominant mammalian cold-temperature thermosensor, is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system, including nerve circuitry i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c32a8bd8200356c5984cf6c6b54e8a8
https://pubmed.ncbi.nlm.nih.gov/30148953
https://pubmed.ncbi.nlm.nih.gov/30148953
Autor:
Sabina Buntich, Amber Umble-Romero, Wei-Jian Pan, L Som, Jason M. Gow, C D Krill, Yu Sun, Samantha P. Prokop, Kathleen Köck, Alexander Colbert, Yu Zhang, Wayne Tsuji, Jennifer E. Towne, T J Goletz, M W Trimble, William A. Rees, John P. Gibbs, Michelle Horner, J C O'Neill, Kathryn J. Newhall
Publikováno v:
British Journal of Pharmacology. 172:159-172
Background and Purpose AMG 139 is a human anti-IL-23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays and in vivo studies were conducted in cynomolgus monkeys to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2df1ca4f60b9725b1651875f7c7b2d
https://doi.org/10.1111/bph.12904
https://doi.org/10.1111/bph.12904
Autor:
Edward S. Friedman, B S Amanda Collier, Robert M. Schwartz, S D O Michelle Horner, Rebecca B. Price, Agnes E. Haggerty, Greg J. Siegle
Publikováno v:
Depression and Anxiety. 31:952-960
Background: Depression involves decreased positive affect. Whether this is due to a failure to achieve or maintain positive emotion in response to discrete stimuli is unclear. Understanding the nature of decreased positive affect could help to addres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2ef35b8115c9ffad05b6ef3f54b79e1
https://doi.org/10.1002/da.22244
https://doi.org/10.1002/da.22244
Autor:
Vanessa Quick, Arunan Kaliyaperumal, Gerald Siu, Michelle Horner, James B. Chung, Richard J. Nicholl, Neil McHugh, Shelley Sims Belouski, John Ferbas, Li Chen, Malcolm Boyce, C. Bernie Colaço
Publikováno v:
British Journal of Clinical Pharmacology. 76:188-202
The aim of the study was to characterize performance of a complementary set of assays to measure antigen-specific immune responses in subjects immunized with a neoantigen. Healthy volunteers (HV) (n = 8) and patients with systemic lupus erythematosus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153a75baeab6dfeab904a3b61e1b75ef
https://doi.org/10.1111/bcp.12172
https://doi.org/10.1111/bcp.12172
Publikováno v:
Drug Discovery Toxicology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c167aa2e6691db03b2a822a07d4535d
https://doi.org/10.1002/9781119053248.ch3
https://doi.org/10.1002/9781119053248.ch3
Autor:
Kelvin K. C. Sham, Lewis D. Pennington, Paul E. Harrington, Matthew R. Lee, Michele McElvain, Xuxia Zhang, Heather A. Arnett, Min Wong, Alexander J. Pickrell, Anthony B. Reed, Henry Morrison, Victor J. Cee, Mike Fiorino, Christopher H. Fotsch, Michael J. Frohn, Yang Xu, Michael Croghan, Han Xu, Brian A. Lanman, Andrew Tasker, Michelle Horner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:527-531
We reveal how a N-scan SAR strategy (systematic substitution of each CH group with a N atom) was employed for quinolinone-based S1P(1) agonist 5 to modulate physicochemical properties and optimize in vitro and in vivo activity. The diaza-analog 17 di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e9317f7724366d80a0b866a4ab4feca
https://doi.org/10.1016/j.bmcl.2011.10.085
https://doi.org/10.1016/j.bmcl.2011.10.085
Autor:
Sabina Buntich, Robert Ortiz, Babette M. Boren, Michelle Horner, Tsui C. Cheah, Suzanne T. Wolford, Wayne Tsuji, Eric A. Butz, Larry C. Wienkers, Jim J. Xiao, Herve Lebrec, Kathleen Köck, Wei. J. Pan, Hong Li, Samantha P. Prokop, Arunan Kaliyaperumal
Publikováno v:
Pharmacology Research & Perspectives
Hu714MuXHu is a recombinant chimeric murine-human monoclonal antibody directed against interleukin-15 (IL-15), a proinflammatory cytokine associated with memory CD8+ and natural killer (NK) T-cell activation and implicated in the pathogenesis of infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aca7bc8ba83417e3c5f630b6cb26978
https://doi.org/10.1002/prp2.199
https://doi.org/10.1002/prp2.199
Autor:
Min Wong, Heather A. Arnett, Michael Croghan, Michele McElvain, Yang Xu, Xuxia Zhang, Matthew R. Lee, Lewis D. Pennington, Paul E. Harrington, Henry Morrison, Victor J. Cee, Anthony B. Reed, Michael J. Frohn, Alexander J. Pickrell, Mike Fiorino, Kelvin K. C. Sham, Han Xu, Brian A. Lanman, Christopher H. Fotsch, Michelle Horner
Publikováno v:
ACS Medicinal Chemistry Letters. 2:752-757
The sphingosine-1-phosphate-1 receptor (S1P1) and its endogenous ligand sphingosine-1-phosphate (S1P) cooperatively regulate lymphocyte trafficking from the lymphatic system. Herein, we disclose 4-methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888681fe352e70d553e6a823a8d63a57
https://doi.org/10.1021/ml2001399
https://doi.org/10.1021/ml2001399
Autor:
Min Wong, Yang Xu, Scot Middleton, Matthew R. Lee, Anu Gore, Mike Fiorino, Alex Pickrell, Kristine M. Muller, Andrea Itano, Mike Frohn, Heather A. Arnett, Janet Buys, Michelle Horner, Dalia Rivenzon-Segal, Jennifer E. Golden, Victor J. Cee, Hugo M. Vargas, Roland Burli, Susana C. Neira, Michael Schrag, Han Xu, Brian A. Lanman, Michele McElvain, Xuxia Zhang, Jerry Siu
Publikováno v:
ACS Medicinal Chemistry Letters. 2:107-112
The optimization of a series of thiazolopyridine S1P1 agonists with limited activity at the S1P3 receptor is reported. These efforts resulted in the discovery of 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo-[5,4-b]pyridin-2-yl)benzyl)azetidine-3-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469aac7dbf0531b12b4eec83f252b55d
https://doi.org/10.1021/ml100306h
https://doi.org/10.1021/ml100306h
Autor:
Hugo M. Vargas, Yang Xu, Jerry Siu, Janet Buys, Michelle Horner, Jian Lin, Ashis Saha, Han Xu, Michele McElvain, Anurag Sharadendu, Scot Middleton, Roland Burli, Yael Marantz, Dalia Segal, Kevin Salyers, Mercedes Lobera, Dilara Mccauley, Srinivas Chereku, Xiang Yu, Nili Schutz, Michael Schrag
Publikováno v:
ACS Medicinal Chemistry Letters. 2:97-101
We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity. 1-((4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl)methyl) azetidine-3-carboxylic acid (18) is a potent S1P1 agonist with >1000× selectivity over S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8291efcc95ecdaf3a6ce8e57343599
https://doi.org/10.1021/ml100227q
https://doi.org/10.1021/ml100227q