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pro vyhledávání: '"Michelle Hoffner O'Connor"'
BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis
Autor:
Michelle Hoffner O’Connor, Ana Berglind, Meaghan M. Kennedy Ng, Benjamin P. Keith, Zachary J. Lynch, Matthew R. Schaner, Erin C. Steinbach, Jeremy Herzog, Omar K. Trad, William R. Jeck, Janelle C. Arthur, Jeremy M. Simon, R. Balfour Sartor, Terrence S. Furey, Shehzad Z. Sheikh
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionIn colitis, macrophage functionality is altered compared to normal homeostatic conditions. Loss of IL-10 signaling results in an inappropriate chronic inflammatory response to bacterial stimulation. It remains unknown if inhibition of bro
Externí odkaz:
https://doaj.org/article/16bc63fbe0be4e3aa778fb80c11bd93c
BET protein inhibition regulates macrophage chromatin accessibility and microbiota-dependent colitis
Autor:
Zachary J. Lynch, Benjamin P Keith, Matthew R. Schaner, Omar K. Trad, R. Balfour Sartor, Janelle C. Arthur, Meaghan M. Kennedy, Terrence S. Furey, Erin C. Steinbach, Jeremy Herzog, Michelle Hoffner O’Connor, Shehzad Z. Sheikh, Ana Berglind, William R. Jeck
IntroductionIn colitis, macrophage functionality is altered compared to homeostatic conditions. Loss of IL-10 signaling results in an inappropriate and chronic inflammatory response to bacterial stimulation. It remains unknown if inhibition of bromod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4efd80e94c5b5dbadb0f1e6bf1a77d
https://doi.org/10.1101/2021.07.15.452570
https://doi.org/10.1101/2021.07.15.452570
Autor:
Takahiko Toyonaga, Nicole Chaumont, Neil D. Shah, Mark J. Koruda, Matt Kanke, Greg R Gipson, Michelle Hoffner O’Connor, Elisabeth A. Wolber, Dimitri G. Trembath, Terrence S. Furey, Jasmine B. Barrow, Wendy A. Pitman, Nevzat Kazgan, Nancy L. Allbritton, Matthew S Schaner, Paul A Cotney, Francisco A. Sylvester, Omar K. Trad, Praveen Sethupathy, Benjamin P. Keith, Shruti J Saxena, Timothy S. Sadiq, Shehzad Z. Sheikh
BACKGROUND. Crohn’s disease (CD) is highly heterogeneous, due in large part to variability in cellular processes that underlie the natural history of CD, thereby confounding effective therapy. There is a critical need to advance understanding of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7d423af630bb33d43122d4a5c5e6a9
https://doi.org/10.1101/307561
https://doi.org/10.1101/307561