Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michelle H. Visagie"'
Publikováno v:
Molecules, Vol 26, Iss 21, p 6388 (2021)
Papaverine (PPV) is an alkaloid isolated from the Papaver somniferum. Research has shown that PPV inhibits proliferation. However, several questions remain regarding the effects of PPV in tumorigenic cells. In this study, the influence of PPV was inv
Externí odkaz:
https://doaj.org/article/9d71d17766b247219e6daacb71be525e
Publikováno v:
Molecules, Vol 26, Iss 3, p 622 (2021)
Recent findings revealed that 2-ethyl-17-oxoestra-1,3,5(10)-trien-3-yl sulfamate (ESE-one) induces antiproliferative activity and cell rounding dependent on the generation of superoxide anion, hydrogen peroxide and peroxyl radical. In the current stu
Externí odkaz:
https://doaj.org/article/ba36a24dd24a488aac2d2d825ce4bf56
Publikováno v:
Molecules, Vol 25, Iss 18, p 4337 (2020)
2-Methoxyestradiol (2ME), a 17β-estradiol metabolite, exerts anticancer properties in vitro and in vivo. To address 2ME’s low bioavailability, research led to the in silico design of sulphamoylated 2ME analogues. However, the role of oxidative str
Externí odkaz:
https://doaj.org/article/37aa21156b1c4bcba046ff060b5a47cc
Publikováno v:
Molecules
Volume 26
Issue 21
Molecules, Vol 26, Iss 6388, p 6388 (2021)
Volume 26
Issue 21
Molecules, Vol 26, Iss 6388, p 6388 (2021)
Papaverine (PPV) is an alkaloid isolated from the Papaver somniferum. Research has shown that PPV inhibits proliferation. However, several questions remain regarding the effects of PPV in tumorigenic cells. In this study, the influence of PPV was inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd076b410a8be79c2947fa1b2f904268
https://pubmed.ncbi.nlm.nih.gov/34770797
https://pubmed.ncbi.nlm.nih.gov/34770797
Autor:
Michelle H. Visagie, Oleg N. Reva, Mokgadi Violet Gwangwa, Maphuti T. Lebelo, Anna Margaretha Joubert, V V Klochko, Namrita Lall, Sunelle Rademan
Publikováno v:
Future Medicinal Chemistry. 11:677-691
Aim: To determine the computer-predicted anticancer activity of mupirocin and to compare its activities with those determined for another polyene antibiotic, batumin. Materials & methods: Molecular docking, cytotoxicity assays, cell microscopy and ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b762f4f6c8fa71b408d4b1d2ceb5e9ec
https://doi.org/10.4155/fmc-2018-0333
https://doi.org/10.4155/fmc-2018-0333
Publikováno v:
Molecules
Volume 25
Issue 18
Molecules, Vol 25, Iss 4337, p 4337 (2020)
Volume 25
Issue 18
Molecules, Vol 25, Iss 4337, p 4337 (2020)
2-Methoxyestradiol (2ME), a 17&beta
estradiol metabolite, exerts anticancer properties in vitro and in vivo. To address 2ME&rsquo
s low bioavailability, research led to the in silico design of sulphamoylated 2ME analogues. However, the role
estradiol metabolite, exerts anticancer properties in vitro and in vivo. To address 2ME&rsquo
s low bioavailability, research led to the in silico design of sulphamoylated 2ME analogues. However, the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e9a11d4bfa835eff62497d0aab3446
https://pubmed.ncbi.nlm.nih.gov/32971805
https://pubmed.ncbi.nlm.nih.gov/32971805
Publikováno v:
Archives of pharmacal research. 42(10)
Glucose is a crucial molecule in energy production and produces different end products in non-tumourigenic- and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose by fermentation and generate lactate and adenosine triphosphate even in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eafc9f0d6ea4a4824fe388582f53966
https://pubmed.ncbi.nlm.nih.gov/31473944
https://pubmed.ncbi.nlm.nih.gov/31473944
Publikováno v:
Biological Research
Biological Research, Volume: 52, Article number: 15, Published: 13 JUN 2019
Biological Research, Vol 52, Iss 1, Pp 1-16 (2019)
Biological Research v.52 2019
SciELO Chile
CONICYT Chile
instacron:CONICYT
Biological Research, Volume: 52, Article number: 15, Published: 13 JUN 2019
Biological Research, Vol 52, Iss 1, Pp 1-16 (2019)
Biological Research v.52 2019
SciELO Chile
CONICYT Chile
instacron:CONICYT
Background Tumourigenic cells modify metabolic pathways in order to facilitate increased proliferation and cell survival resulting in glucose- and glutamine addiction. Previous research indicated that glutamine deprivation resulted in potential diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8c28f95a32b38fb8fb359b934b62d9
http://europepmc.org/articles/PMC6437944
http://europepmc.org/articles/PMC6437944
Publikováno v:
Molecules
Volume 26
Issue 3
Molecules, Vol 26, Iss 622, p 622 (2021)
Volume 26
Issue 3
Molecules, Vol 26, Iss 622, p 622 (2021)
Recent findings revealed that 2-ethyl-17-oxoestra-1,3,5(10)-trien-3-yl sulfamate (ESE-one) induces antiproliferative activity and cell rounding dependent on the generation of superoxide anion, hydrogen peroxide and peroxyl radical. In the current stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a232fec9af8213e03309226f1a131c15
https://doi.org/10.3390/molecules26030622
https://doi.org/10.3390/molecules26030622
Autor:
Rustelle Janse van Vuuren, Michelle H. Visagie, Tamarin Jurgens, Anna Margaretha Joubert, Mandie Botes, Zohreh Riahi, Iman van den Bout
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-12 (2018)
Cancer Cell International
Cancer Cell International
Background 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical application. Therefore, more stable deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b481eae8d0611f219ec251ad3cfbc77a
https://doi.org/10.1186/s12935-018-0688-7
https://doi.org/10.1186/s12935-018-0688-7