Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Michelle H Theus"'
Autor:
John Leonard, Xiaoran Wei, Jack Browning, Erwin Kristobal Gudenschwager-Basso, Jiangtao Li, Elizabeth A. Harris, Michelle L. Olsen, Michelle H. Theus
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Post-traumatic epilepsy (PTE) stands as one of the numerous debilitating consequences that follow traumatic brain injury (TBI). Despite its impact on many individuals, the current landscape offers only a limited array of reliable treatment o
Externí odkaz:
https://doaj.org/article/9cb92b6879b543e8954ff19ab63f43ae
Autor:
Erwin K. Gudenschwager Basso, Jing Ju, Eman Soliman, Caroline de Jager, Xiaoran Wei, Kevin J. Pridham, Michelle L. Olsen, Michelle H. Theus
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Monocytes represent key cellular elements that contribute to the neurological sequela following brain injury. The current study reveals that trauma induces the augmented release of a transcriptionally distinct CD115+/Ly6Chi monocyte populati
Externí odkaz:
https://doaj.org/article/4a71437ef1c1430cb5de1c3e6795ff40
Autor:
Eman Soliman, John Leonard, Erwin Kristobal Gudenschwager Basso, Ilana Gershenson, Jing Ju, Jatia Mills, Caroline de Jager, Alexandra M. Kaloss, Mohamed Elhassanny, Daniela Pereira, Michael Chen, Xia Wang, Michelle H. Theus
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background Efferocytosis is a process that removes apoptotic cells and cellular debris. Clearance of these cells alleviates neuroinflammation, prevents the release of inflammatory molecules, and promotes the production of anti-inflammatory c
Externí odkaz:
https://doaj.org/article/9af10e8dd4b0412e9b14f181068792d0
Autor:
Michelle H. Theus
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Acquired traumatic central nervous system (CNS) injuries, including traumatic brain injury (TBI) and spinal cord injury (SCI), are devastating conditions with limited treatment options. Neuroinflammation plays a pivotal role in secondary damage, maki
Externí odkaz:
https://doaj.org/article/da81f69fcde14015b9409ef696edbcdc
Autor:
Yumeng Zhu, Yulia Shmidov, Elizabeth A. Harris, Michelle H. Theus, Ronit Bitton, John B. Matson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Cryptic sites are short signaling peptides buried within the native extracellular matrix (ECM). Enzymatic cleavage of an ECM protein reveals these hidden peptide sequences, which interact with surface receptors to control cell behavior. Mate
Externí odkaz:
https://doaj.org/article/11a43ebb99834ecb811c4f5d4abaf2b3
Autor:
Elizabeth A. Kowalski, Eman Soliman, Colin Kelly, Erwin Kristobal Gudenschwager Basso, John Leonard, Kevin J. Pridham, Jing Ju, Alison Cash, Amanda Hazy, Caroline de Jager, Alexandra M. Kaloss, Hanzhang Ding, Raymundo D. Hernandez, Gabe Coleman, Xia Wang, Michelle L. Olsen, Alicia M. Pickrell, Michelle H. Theus
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Circulating monocytes have emerged as key regulators of the neuroinflammatory milieu in a number of neuropathological disorders. Ephrin type A receptor 4 (Epha4) receptor tyrosine kinase, a prominent axon guidance molecule, has recently been implicat
Externí odkaz:
https://doaj.org/article/d48e080f6aa64183bed8ef43cb49ca19
Autor:
Lauren E. Fritsch, Jing Ju, Erwin Kristobal Gudenschwager Basso, Eman Soliman, Swagatika Paul, Jiang Chen, Alexandra M. Kaloss, Elizabeth A. Kowalski, Taylor C. Tuhy, Rachana Deven Somaiya, Xia Wang, Irving Coy Allen, Michelle H. Theus, Alicia M. Pickrell
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/d9ab8713b53e4633b3a619d0156e97a9
Autor:
Lauren E. Fritsch, Jing Ju, Erwin Kristobal Gudenschwager Basso, Eman Soliman, Swagatika Paul, Jiang Chen, Alexandra M. Kaloss, Elizabeth A. Kowalski, Taylor C. Tuhy, Rachana Deven Somaiya, Xia Wang, Irving Coy Allen, Michelle H. Theus, Alicia M. Pickrell
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
BackgroundInflammation is a significant contributor to neuronal death and dysfunction following traumatic brain injury (TBI). Recent evidence suggests that interferons may be a key regulator of this response. Our studies evaluated the role of the Cyc
Externí odkaz:
https://doaj.org/article/3f36ff5605e34bd699e56d14972c3aaf
Autor:
Erwin Kristobal Gudenschwager-Basso, Oleksii Shandra, Troy Volanth, Dipan C. Patel, Colin Kelly, Jack L. Browning, Xiaoran Wei, Elizabeth A. Harris, Dzenis Mahmutovic, Alexandra M. Kaloss, Fernanda Guilhaume Correa, Jeremy Decker, Biswajit Maharathi, Stefanie Robel, Harald Sontheimer, Pamela J. VandeVord, Michelle L. Olsen, Michelle H. Theus
Publikováno v:
Cells, Vol 12, Iss 9, p 1248 (2023)
Background: Traumatic brain injury (TBI) remains a significant risk factor for post-traumatic epilepsy (PTE). The pathophysiological mechanisms underlying the injury-induced epileptogenesis are under investigation. The dentate gyrus—a structure tha
Externí odkaz:
https://doaj.org/article/bebfb1ee64114a2ba984cef78cea5921
Autor:
Alexandra M. Kaloss, Lauren N. Arnold, Eman Soliman, Maya Langman, Nathalie Groot, Eli Vlaisavljevich, Michelle H. Theus
Publikováno v:
BME Frontiers, Vol 2022 (2022)
Objective and Impact Statement. This study examined the efficacy and safety of pulsed, low-intensity focused ultrasound (LIFU) and determined its ability to provide neuroprotection in a murine permanent middle cerebral artery occlusion (pMCAO) model.
Externí odkaz:
https://doaj.org/article/0c6d612cc57a472da9c93ac08fda33b6